Výsledky vyhledávání

Evaluation of systemically administered radiolabeled epidermal growth factor as a brain tumor targeting agent

Autor: W, Yang, R F, Barth, R, Leveille, D M, Adams, M, Ciesielski, R A, Fenstermaker, J, Capala

Publikováno v: Journal of neuro-oncology. 55(1)

We have previously reported a method for labeling epidermal growth factor (EGF) with technetium-99m and have shown that 99mTc-EGF localized in EGF receptor (R) positive intracerebral C6EGFR rat gliomas following intratumoral (i.t.) injection of the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2386ad287d07e8b8ffe9186e31d0bbc1
https://pubmed.ncbi.nlm.nih.gov/11804279

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Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy

Autor: D R, Smith, S, Chandra, R F, Barth, W, Yang, D D, Joel, J A, Coderre

Publikováno v: Cancer research. 61(22)

Boron neutron capture therapy (BNCT) is dependent on the selective accumulation of boron-10 in tumor cells relative to the contiguous normal cells. Ion microscopy was used to evaluate the microdistribution of boron-10 from p-boronophenylalanine (BPA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf1cb388b09d83806d9ab829fe745a8e
https://pubmed.ncbi.nlm.nih.gov/11719448

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Boron neutron capture therapy of brain tumors: investigation of urinary metabolites and oxidation products of sodium borocaptate by electrospray ionization mass spectrometry

Autor: C R, Gibson, A E, Staubus, R F, Barth, W, Yang, N M, Kleinholz, R B, Jones, K, Green-Church, W, Tjarks, A H, Soloway

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(12)

Boron neutron capture therapy (BNCT) is based on a nuclear capture reaction that occurs when boron-10, a stable isotope, is irradiated with low energy neutrons to produce high-energy alpha particles and recoiling lithium-7 nuclei. The purpose of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2dd31bc1bffc3a192d77719f9596f4f
https://pubmed.ncbi.nlm.nih.gov/11717178

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In vivo evaluation of phosphorous-containing derivatives of dodecahydro-closo-dodecaborate for boron neutron capture therapy of gliomas and sarcomas

Autor: W, Tjarks, R F, Barth, J H, Rotaru, D M, Adams, W, Yang, R G, Kultyshev, J, Forrester, B A, Barnum, A H, Soloway, S G, Shore

Publikováno v: Anticancer research. 21(2A)

The in vivo uptake of dodecahydro-closo-dodecaborate derivatives substituted with phosphate- and bisphosphonate groups was evaluated in two different experimental tumor model systems and compared to other boronated and non-boronated compounds. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c671afcd229d027441f6eb90fbb44d4
https://pubmed.ncbi.nlm.nih.gov/11396173

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Comparative in vitro evaluation of dequalinium B, a new boron carrier for neutron capture therapy (NCT)

Autor: D M, Adams, W, Ji, R F, Barth, W, Tjarks

Publikováno v: Anticancer research. 20(5B)

A boronated derivative of dequalinium, a delocalized lipophilic cation (DLC), was synthesized as a potential boron carrier for the selective targeting of mitochondria in malignant versus benign cells for boron neutron capture therapy (BNCT), a binary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b1cbdb89c92cc283b787afd056a5a9e
https://pubmed.ncbi.nlm.nih.gov/11131639

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Boron neutron capture therapy of brain tumors: functional and neuropathologic effects of blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine

Autor: W, Yang, R F, Barth, J H, Rotaru, C P, Boesel, D A, Wilkie, J C, Bresnahan, M, Hadjiconstantinou, V M, Goettl, D D, Joel, M M, Nawrocky

Publikováno v: Journal of neuro-oncology. 48(3)

Sodium borocaptate (BSH) and boronophenylalanine (BPA) are two drugs that have been used clinically for boron neutron capture therapy (BNCT) of brain tumors. We previously have reported that hyperosmotic mannitol-induced disruption of the blood-brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a29e7d3d305854e7c5644b772756284
https://pubmed.ncbi.nlm.nih.gov/11100816

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Synthesis and evaluation of DNA tumor targeting agents for neutron capture therapy

Autor: Jianghai Wang, A. J. Lunato, Jin-Cong Zhuo, Staffan Eriksson, Werner Tjarks, R. F. Barth, J. Cai, A. H. Soloway, Dianne M. Adams, Weihua Ji

Publikováno v: Contemporary Boron Chemistry ISBN: 9780854048359

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d7d67a563b4a279a993ad44bcd9a884
https://doi.org/10.1039/9781847550644-00127

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Transfusion-associated graft-vs-host disease. A fatal case caused by blood from an unrelated HLA homozygous donor

Autor: T E, Gorman, C J, Julius, R F, Barth, A, Ng, M S, Kennedy, T W, Prior, J, Allen, L C, Lasky

Publikováno v: American journal of clinical pathology. 113(5)

Transfusion-associated graft-vs-host disease (TA-GVHD) is a rare complication of transfusion. We report fatal TA-GVHD in a 63-year-old coronary artery bypass patient of European descent after an RBC transfusion from an unrelated donor. The patient ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325a1bfd13bfa7559a661849c71a8827
https://pubmed.ncbi.nlm.nih.gov/10800407

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