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Order, Disorder and Fibril Formation in the Malaria Vaccine Candidate MSP2

Autor: R. S. Norton, S. Yao, Vincent John. Murphy, R. F. Anders, Matthew A. Perugini, A. Low, X. Zhang, X. Yang, C. G. Adda

Publikováno v: Journal of Proteomics & Bioinformatics. :070-071

Merozoite surface protein 2 (MSP2) is synthesized by asexual blood stages of the human malaria parasite Plasmodium falciparum as a GPI-anchored protein. It has been implicated in erythrocyte invasion and is being developed as a vaccine candidate. NMR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::114fe86fe5b813ced3f92fd6b4b99b18
https://doi.org/10.4172/jpb.s1000063

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A cryptic T cell epitope on the apical membrane antigen 1 of Plasmodium chabaudi adami can prime for an anamnestic antibody response: implications for malaria vaccine design

Autor: F H, Amante, P E, Crewther, R F, Anders, M F, Good

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(11)

We have investigated the proliferative and Th cell responses to the Plasmodium chabaudi adami DS homologue of the Plasmodium falciparum apical membrane Ag 1 (AMA-1), a leading malaria vaccine candidate. Immunodominant T cell epitopes were defined fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87740127d54a33f87e268d1ecee7037a
https://pubmed.ncbi.nlm.nih.gov/9548494

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Conservation of structural motifs and antigenic diversity in the Plasmodium falciparum merozoite surface protein-3 (MSP-3)

Autor: D J, McColl, R F, Anders

Publikováno v: Molecular and biochemical parasitology. 90(1)

Merozoite surface protein-3 (MSP-3) is a secreted polymorphic antigen associated with erythrocytic schizonts and merozoites of Plasmodium falciparum asexual blood-stages. A prominent structural feature of MSP-3 is a domain composed of three blocks of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c1285afe2dcbac350b6baf2f6776485
https://pubmed.ncbi.nlm.nih.gov/9497029

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Mapping a conserved conformational epitope from the M protein of group A streptococci

Autor: W A, Relf, J, Cooper, E R, Brandt, W A, Hayman, R F, Anders, S, Pruksakorn, B, Currie, A, Saul, M F, Good

Publikováno v: Peptide research. 9(1)

The carboxyl terminus of the M protein of group A streptococci (GAS) is highly conserved and contains epitopes that have been shown to induce opsonic antibodies and protection against GAS infection. This region of the protein can also stimulate T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::380402104bea4ecd7ada148e40f3f917
https://pubmed.ncbi.nlm.nih.gov/8727479

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Adherence of infected erythrocytes to venular endothelium selects for antigenic variants of Plasmodium falciparum

Autor: B A, Biggs, R F, Anders, H E, Dillon, K M, Davern, M, Martin, C, Petersen, G V, Brown

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 149(6)

Erythrocytes (E) infected with asexual forms of malaria parasites exhibit surface antigenic variation. In Plasmodium falciparum infections, the variant Ag is the P. falciparum E membrane protein 1 (PfEMP1). This molecule may also mediate the adherenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::11cc56f317fb0a674ff41095f32dbed3
https://pubmed.ncbi.nlm.nih.gov/1517569

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Antigenic diversity in Plasmodium falciparum

Autor: R F, Anders

Publikováno v: Acta Leidensia. 60(1)

There are several mechanisms responsible for the extensive antigenic diversity found in the asexual blood stages of Plasmodium falciparum. Failure to express antigens is a feature of many isolates cultured in vitro but probably is not a major cause o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::306f881afd9a1a16c32b7e7588f70ce5
https://pubmed.ncbi.nlm.nih.gov/1820715

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