Zobrazeno 1 - 10
of 61
pro vyhledávání: '"R F, Adams"'
Autor:
R F Adams, Edoardo Gaude, Simon Wigfield, Gerald Hoefler, Fredrik Karpe, Simon Lord, Jennifer Collins, Pankaj G. Roy, Ulrike Harjes, Francesca M. Buffa, Ruth English, Michael Pollak, Alastair M. Thompson, Pooja Jha, Katherine E. Pinnick, Wei-Chen Cheng, Syed Haider, Barbara A. Fielding, Adrian L. Harris, Ashvina Segaran, Christian Frezza
Publikováno v:
British Journal of Cancer
Background Epidemiological studies suggest that metformin may reduce the incidence of cancer in patients with diabetes and multiple late phase clinical trials assessing the potential of repurposing this drug are underway. Transcriptomic profiling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577b9948a54adccc595d579b5e1b9cd9
https://www.repository.cam.ac.uk/handle/1810/314930
https://www.repository.cam.ac.uk/handle/1810/314930
Autor:
Sonia Li, Simon Lord, N P Hughes, Ruud G.P.M. van Stiphout, Andreas Makris, R F Adams, Adrian M. Jubb, Lefteris Koumakis, S Mehta, Francesca M. Buffa, Adrian L. Harris, Anwar R. Padhani
Publikováno v:
EBioMedicine
EBioMedicine, Vol 10, Iss C, Pp 109-116 (2016)
EBioMedicine, Vol 10, Iss C, Pp 109-116 (2016)
Anti-VEGF antibody bevacizumab has prolonged progression-free survival in several cancer types, however acquired resistance is common. Adaption has been observed pre-clinically, but no human study has shown timing and genes involved, enabling formula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ceaf12d0292dcef2007f8e74fe4ce07
https://doi.org/10.1016/j.ebiom.2016.07.017
https://doi.org/10.1016/j.ebiom.2016.07.017
Autor:
Neel Patel, Lisa Ayers, Ioannis Roxanis, Luc Bidaut, Fredrik Karpe, Simon Lord, Mei Lin Ah-See, Christos E. Zois, Cameron Snell, Pankaj G. Roy, Christian Frezza, Leticia Campo, Adrian L. Harris, Francesca M. Buffa, Kevin M. Bradley, Ruth English, Fergus V. Gleeson, Tim James, R F Adams, Tom Metcalf, Syed Haider, Anand Sharma, Daniel R. McGowan, Dan Liu, Eugene J. Teoh, John D. Fenwick, Michael Pollak, Edoardo Gaude, Wei Chen Cheng, Simon Wigfield, Alastair M. Thompson
Publikováno v:
CELL METABOLISM
Cell Metabolism
Cell Metabolism
Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating measurement of marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a168f8387e5f05dbe5abffbe69c6fc
https://www.repository.cam.ac.uk/handle/1810/285637
https://www.repository.cam.ac.uk/handle/1810/285637
Autor:
Andreas Makris, N P Hughes, Anwar R. Padhani, Sonia P. Li, Francesca M. Buffa, Cheng Han, NJ Taylor, S Mehta, K Kaur, Al Harris, R F Adams
Publikováno v:
Cancer Research. 72:P1-06
Background: Recently the FDA has withdrawn the indication for bevacizumab in metastatic breast cancer after several clinical studies failed to demonstrate an overall survival benefit. These studies however did report an increase in response rates to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90b01fae581d781b3a02e74b4514a49d
https://doi.org/10.1158/0008-5472.sabcs12-p1-06-01
https://doi.org/10.1158/0008-5472.sabcs12-p1-06-01
Autor:
Anwar R. Padhani, N C Levitt, S Mehta, N P Hughes, Sonia P. Li, Andreas Makris, R F Adams, A Adwani, Francesca M. Buffa, NJ Taylor, Adrian L. Harris
Publikováno v:
JNCI Monographs
Antiangiogenic therapy is a promising approach for the treatment of breast cancer. In practice, however, only a subset of patients who receive antiangiogenic drugs demonstrate a significant response. A key challenge, therefore, is to discover biomark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047747ff69b47c1ea95fa2f377d6503f
https://doi.org/10.1093/jncimonographs/lgr027
https://doi.org/10.1093/jncimonographs/lgr027
Autor:
Sonia P. Li, Anwar R. Padhani, R F Adams, NJ Taylor, Francesca M. Buffa, S Mehta, Andreas Makris, N P Hughes, A Adwani, A L Harris, N C Levitt
Publikováno v:
Cancer Research. 70:P2-09
Background: Bevacizumab is an approved drug for advanced breast cancer alongside chemotherapy. To date there is no biomarker proven to be effective in patient stratification. To address this, a window of opportunity study was designed where bevacizum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c472b29cd84cd2b574ce47fc74d472c4
https://doi.org/10.1158/0008-5472.sabcs10-p2-09-28
https://doi.org/10.1158/0008-5472.sabcs10-p2-09-28
Publikováno v:
Chest. 120:1798-1802
Study objectives: Pleural fluid cytology and non–image-guided Abrams or Cope biopsies have sensitivities of approximately 30% for detecting malignant mesothelioma, and thoracoscopic biopsy has a sensitivity of approximately 90%. The difference betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e872341834005fff29b83acec2bfc4b
https://doi.org/10.1378/chest.120.6.1798
https://doi.org/10.1378/chest.120.6.1798
Publikováno v:
Clinical Radiology. 56:676-680
An 18-year-old-man was referred to the Neurology Department complaining of headache and double vision. The headache was exquisitely sensitive to postural changes, being completely abolished by lying at. Neurological examination revealed an isolated r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7c85fb437e3a28cafc5218ef5eeac6
https://doi.org/10.1053/crad.1999.0461
https://doi.org/10.1053/crad.1999.0461
Autor:
P. Anslow, R. F. Adams
Publikováno v:
Neuroradiology. 43:383-387
We report a patient with a Brown-Séquard syndrome who developed ventral transdural spinal cord herniation, showing the imaging findings changing over time from two thoracic disc protrusions with a normal spinal cord to a cord trapped within a bony d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2c226ed0a736be57eba4fc4553aa86
https://doi.org/10.1007/s002340000469
https://doi.org/10.1007/s002340000469
Autor:
John L. Porter, Otto Landen, Guy R. Bennett, L. E. Ruggles, R. F. Adams, C. Wakefield, Walter W. Simpson
Publikováno v:
Review of Scientific Instruments. 72:657-662
The Z-Beamlet laser backlighter system at Sandia National Laboratories, which will be operational in 2001, will create a point or area source of high (or moderate) energy x rays behind a Z-accelerator [R. B. Spielman et al., Phys. Plasmas 5, 2105 (19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f91f1ce0b995b03f30075a17188b49
https://doi.org/10.1063/1.1315645
https://doi.org/10.1063/1.1315645