Výsledky vyhledávání - "R Eugene, Ramsay"

Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open‐label , dose‐finding , phase 2 trial

Autor: Henrikas Vaitkevicius, R. Eugene Ramsay, Christa B. Swisher, Aatif M. Husain, Alex Aimetti, Maciej Gasior

Publikováno v: Epilepsia. 63:2381-2391

Patients with refractory status epilepticus (RSE) have failed treatment with benzodiazepines and ≥1 second-line intravenous (IV) antiseizure medication (ASM). Guidelines recommend IV anesthesia when second-line ASMs have failed, but potential harms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1f65e0fa62a0b6331ff0fee751efab
https://doi.org/10.1111/epi.17343

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Safety, tolerability, and pharmacokinetics of weight-based IV loading dose of lacosamide in the ICU

Autor: Vivek Sabharwal, R. Eugene Ramsay, Anil K. Chimakurthy, Uma Menon

Publikováno v: Epilepsybehavior : EB. 114

Among the newer antiseizure medications, lacosamide (LCM) has been increasingly used for acute seizures and status epilepticus in intensive care unit (ICU). We reviewed retrospectively weight-based dosing of IV LCM in patients admitted to ICU with ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8238aaabda80aaa87709013a7c9b73
https://pubmed.ncbi.nlm.nih.gov/32943331

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Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy

Autor: Lynn E. Eberly, Joseph F. Collins, R. Eugene Ramsay, Angela K. Birnbaum, Jeannine M. Conway, Flavia M Macias, Ilo E. Leppik

Publikováno v: Pharmacotherapy

Objectives To characterize and quantify the variability of serial gabapentin concentrations in elderly patients with epilepsy. Methods This study included 83 patients (age ≥60 years) from an 18-center, randomized, double-blind, double dummy, parall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0671a54e99cebe3a49ff547a7d80d68
https://doi.org/10.1002/phar.2012

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Comparative analysis of the safety and tolerability of eslicarbazepine acetate in older (≥60 years) and younger (18–59 years) adults

Autor: Eva Andermann, Mar Carreño, Elinor Ben-Menachem, F. Rocha, Helena Gama, Joanne Rogin, David Blum, Robert Tosiello, Fernando Cendes, Todd Grinnell, William E. Rosenfeld, R. Eugene Ramsay, Patrício Soares-da-Silva, Patricia Penovich

Publikováno v: Epilepsy Research. 169:106478

Objective To investigate the safety and tolerability of eslicarbazepine acetate (ESL), a once-daily oral anti-seizure drug (ASD), in older and younger adult patient populations. Methods Two post-hoc pooled data analyses were performed: one from three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b8d73099314e0c73b302c0c9a6fa77
https://doi.org/10.1016/j.eplepsyres.2020.106478

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Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age

Autor: Brett M. Kistner, Akshanth R. Polepally, R. Eugene Ramsay, Ilo E. Leppik, James R. White, Rory P. Remmel, Angela K. Birnbaum, Page B. Pennell, Richard C. Brundage

Publikováno v: Epilepsia. 59(9)

Objective The objectives of this study were to investigate the effect of age on pharmacokinetic parameters of lamotrigine (LTG) and estimate parameter variability. Methods Patients (>18 years old) who were already on a steady-state dose of LTG therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b45e55ae71f8b60891cd9996658b07
https://pubmed.ncbi.nlm.nih.gov/30101556

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Population Pharmacokinetics of Unbound and Total Drug Concentrations Following Intravenously Administered Carbamazepine in Elderly and Younger Adult Patients With Epilepsy

Autor: Susan E. Marino, R. Eugene Ramsay, Page B. Pennell, Richard C. Brundage, Ghada F. Ahmed, Angela K. Birnbaum, James C. Cloyd, Ilo E. Leppik

Publikováno v: The Journal of Clinical Pharmacology. 53:276-284

The objective of the study was to investigate the pharmacokinetics (PK) of unbound and total plasma carbamazepine (CBZ) concentrations following simultaneous administration of intravenous and oral formulations. We tested the hypothesis that age-relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78f1a5767d41c51a2c34800056142f35
https://doi.org/10.1002/jcph.8

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