Zobrazeno 1 - 10
of 24
pro vyhledávání: '"R E Pitas"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 11, Pp 2207-2215 (1997)
Peritoneal macrophages are easily isolated by lavage, suggesting that they are either nonadherent or weakly adherent in situ. Cultured macrophages express class A scavenger receptors (SCR), which mediate Ca2+-independent adhesion in vitro. We examine
Externí odkaz:
https://doaj.org/article/eec80fb4584443ef9cb8b54b36871891
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 11, Pp 2207-2215 (1997)
Peritoneal macrophages are easily isolated by lavage, suggesting that they are either nonadherent or weakly adherent in situ. Cultured macrophages express class A scavenger receptors (SCR), which mediate Ca2+-independent adhesion in vitro. We examine
Autor:
Stefano Bellosta, J Murata, J M Taylor, Robert W. Mahley, David A. Sanan, R E Pitas, Dale L. Newland
Publikováno v:
Journal of Clinical Investigation. 96:2170-2179
apoE deficiency causes hyperlipidemia and premature atherosclerosis. To determine if macrophage-specific expression of apoE would decrease the extent of atherosclerosis, we expressed human apoE in macrophages of apoE-null mice (apoE-/-) and assessed
Publikováno v:
The Journal of biological chemistry. 275(23)
Oxidative stress caused by phorbol esters or reactive oxygen up-regulates the class A scavenger receptor (SR-A) in human smooth muscle cells (SMC), which normally do not express this receptor. The increase in SR-A expression correlates with activatio
Contributions of the Glial Injury Response to the Multifactorial Pathogenesis of Alzheimer’s Disease
Publikováno v:
Research and Perspectives in Neurosciences ISBN: 9783642640650
Alzheimer’s disease (AD) is the leading cause of cognitive deficits in the elderly. As longevity of many populations has increased, so has the number of people suffering from this devastating illness (Ott et al. 1998).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccc8e29f7c9cd9a3fa86015f1e871081
https://doi.org/10.1007/978-3-642-59643-8_3
https://doi.org/10.1007/978-3-642-59643-8_3
Publikováno v:
The Journal of biological chemistry. 273(22)
Isoform-specific effects of apolipoprotein E (apoE) on neurite outgrowth and the cytoskeleton are associated with higher intracellular levels of apoE3 than apoE4 in cultured neurons. The current studies, designed to determine the mechanism for the di
Publikováno v:
Apolipoprotein E and Alzheimer’s Disease ISBN: 9783642801112
Apolipoprotein E (apoE) is a 34000-Da protein that functions in the redistri bution of lipids among various tissues. Several observations over the years have suggested that apoE has a role in neurobiology. Most recently it has been associated with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf0585e8c79bec82d40e67804e43c635
https://doi.org/10.1007/978-3-642-80109-9_5
https://doi.org/10.1007/978-3-642-80109-9_5
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 5(10)
Increasing evidence suggests that the formation of oxidized low-density lipoprotein (Ox-LDL) in vivo is associated with the development of atherosclerotic vascular disease. We investigated the effects of Ox-LDL on two vascular endothelial cell coagul
Publikováno v:
The Journal of biological chemistry. 266(14)
To investigate the mechanisms controlling tissue-specific expression of the human apolipoprotein (apo) E/C-I gene locus, human apoE and apoC-I gene constructs containing various lengths of the 5'-flanking or 3'-flanking region were used to create tra
Autor:
R E, Pitas
Publikováno v:
The Journal of biological chemistry. 265(21)
The acetyl low density lipoprotein (LDL), or scavenger, receptor, which binds modified forms of LDL, was thought to be expressed only on macrophages and endothelial cells. We demonstrate that rabbit fibroblasts and smooth muscle cells bind, internali