Zobrazeno 1 - 10
of 23
pro vyhledávání: '"R E M Toes"'
Autor:
M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami, M. Tamai, S. Kawashiri, T. Maeda, T. W. J. Huizinga, R. E. M. Toes, D. van der Woude
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Abstract Background Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically carbamylated and acetyl
Externí odkaz:
https://doaj.org/article/ec63abc66b2841cfad7300c08235385f
Autor:
H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen, J. C. Kwekkeboom, A. H. van der Helm-van Mil, R. E. M. Toes, F. A. van Gaalen
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Background Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor prognosis compared to
Externí odkaz:
https://doaj.org/article/c35151cafc3e474e8f7a2bbafd15db69
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-7 (2018)
Abstract Background Anti-citrullinated protein antibodies (ACPA) are associated with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and murine studies indicate that ACPAs can directly
Externí odkaz:
https://doaj.org/article/2c46fe6c611447da9c03eb20323a9b41
Autor:
T C Messemaker, M Frank-Bertoncelj, R B Marques, A Adriaans, A M Bakker, N Daha, S Gay, T W Huizinga, R E M Toes, H M M Mikkers, F Kurreeman
Publikováno v:
Genes and Immunity, 17(2), 85-92
Long non-coding RNAs (lncRNAs) can regulate the transcript levels of genes in the same genomic region. These locally acting lncRNAs have been found deregulated in human disease and some have been shown to harbour quantitative trait loci (eQTLs) in au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4bff01b3c140a07b384d183a2939ff
https://doi.org/10.1038/gene.2015.54
https://doi.org/10.1038/gene.2015.54
Autor:
H W, van Steenbergen, S, Raychaudhuri, L, Rodríguez-Rodríguez, S, Rantapää-Dahlqvist, E, Berglin, R E M, Toes, T W J, Huizinga, B, Fernández-Gutiérrez, P K, Gregersen, A H M, van der Helm-van Mil
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 67(4)
For decades it has been known that the HLA-DRB1 shared epitope (SE) alleles are associated with an increased risk of development and progression of rheumatoid arthritis (RA). Recently, the following variations in the peptide-binding grooves of HLA mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2099825ac99bfbaa79ecb20ce869bc7d
https://pubmed.ncbi.nlm.nih.gov/25580908
https://pubmed.ncbi.nlm.nih.gov/25580908
Autor:
R, Knevel, D P C, de Rooy, A, Zhernakova, G, Gröndal, A, Krabben, K, Steinsson, C, Wijmenga, G, Cavet, R E M, Toes, T W J, Huizinga, P K, Gregersen, A H M, van der Helm-van Mil
Publikováno v:
Arthritis and rheumatism. 65(7)
Heritability studies have suggested an important role of genetic predisposition in the progression of joint destruction in rheumatoid arthritis (RA); the heritability is estimated at 45-58%. Several single-nucleotide polymorphisms (SNPs) have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::185b4477ecd0dc4497b781ad5758261a
https://pubmed.ncbi.nlm.nih.gov/23529819
https://pubmed.ncbi.nlm.nih.gov/23529819
Publikováno v:
Handbook of experimental pharmacology. (188)
Dendritic cells (DC) are the professional antigen presenting cells that protect us against invading organisms. On the other hand, they uphold tolerance thereby avoiding the initiation of autoimmunity. In performing these contrasting but essential tas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8016b3456d503844492f028d533851c6
https://pubmed.ncbi.nlm.nih.gov/19031022
https://pubmed.ncbi.nlm.nih.gov/19031022
Publikováno v:
Clinical and experimental rheumatology. 25(5)
Ligands for the receptor for advanced glycation endproducts (RAGE) are increased in RA synovial fluid (SF), serum and synovium. Since RAGE is present on fibroblast-like synoviocytes (FLS), the present study investigates whether the RAGE ligands HMGB-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fedaadb5a9a066b95984f0969ad90cda
https://pubmed.ncbi.nlm.nih.gov/18078623
https://pubmed.ncbi.nlm.nih.gov/18078623
Publikováno v:
Clinical and experimental rheumatology. 25(2)
In vitro models for joint diseases often focus on a single cell type, such as chondrocytes in osteoarthritis (OA) or fibroblast-like synoviocytes (synoviocytes) in rheumatoid arthritis (RA). However, these joint diseases affect the whole joint and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::744ff491353c27296a69231829c50179
https://pubmed.ncbi.nlm.nih.gov/17543148
https://pubmed.ncbi.nlm.nih.gov/17543148
Autor:
T C A, Tolboom, Y-H, Zhang, N V, Henriquez, R G H H, Nelissen, R E M, Toes, M H M, Noteborn, T W J, Huizinga
Publikováno v:
Clinical and experimental rheumatology. 24(2)
Fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) show characteristics of transformation. Because the chicken anemia virus protein, apoptin, induces apoptosis solely in transformed cells, it was investigated whether FLS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96b3f397cbac49170928f531157dc3f8
https://pubmed.ncbi.nlm.nih.gov/16762148
https://pubmed.ncbi.nlm.nih.gov/16762148