Zobrazeno 1 - 10 of 176 pro vyhledávání: '"R E Leake"'
1
A prognostic index for operable, node-negative breast cancer
Autor: Colin A. Purdie, Michael Steel, Anne L. Robertson, HJ Stewart, J Paxton, M McCallum, B B Cohen, C Baker, David Cameron, R E Leake, R. C. F. Leonard, A Gould, K Gillespie
Publikováno v: British Journal of Cancer
There is long-standing controversy over the management of small, node-negative breast cancers. Surgical excision, with or without local radiotherapy, plus adjuvant tamoxifen will result in long-term disease-free survival for some 80% of patients. On
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685b4461f822c0e296c42652b351fd18
https://doi.org/10.1038/sj.bjc.6601826
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2
The Effect of EGFR-Related Tyrosine Kinase Activity Inhibition on the Growth and Invasion Mechanisms of Prostate Carcinoma Cell Lines
Autor: A, Unlü, R E, Leake
Publikováno v: The International Journal of Biological Markers. 18:139-146
Increased urokinase plasminogen activator (uPA) levels and epidermal growth factor receptor (EGFR)-related tyrosine kinase activity are associated with poor prognosis in several cancers. We studied the effect of epidermal growth factor (EGF) and a sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e75fe131cb38119fb40ad6678b2c1f
https://doi.org/10.1177/172460080301800207
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3
Inhibition of transforming growth factor α (TGF-α)-mediated growth effects in ovarian cancer cell lines by a tyrosine kinase inhibitor ZM 252868
Autor: John M. S. Bartlett, E.P. Miller, G. J. Rabiasz, John F. Smyth, P Gordge, A L Rae, R E Leake, B. J. B. Simpson, Kenneth G. MacLeod, Simon P. Langdon, William R. Miller
Publikováno v: British Journal of Cancer
The modulating effects of the epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor ZM 252868 on cell growth and signalling have been evaluated in four ovarian carcinoma cell lines PE01, PE04, SKOV-3 and PE01CDDP. Transforming gro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d702bf8ade2effa08474bd17ed0314
http://europepmc.org/articles/PMC2362251
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4
Local Hyperthermia for Prostatic Disease: in vitro Studies on Human Prostatic Cancer Cell Lines
Autor: R. E. Leake, D. Kirk, S. N. Lloyd, D Chalmers
Publikováno v: British Journal of Urology. 70:529-533
Local hyperthermia for benign and malignant prostatic disease remains largely empirical. In an attempt to understand the biological action of hyperthermia, and its potentiation by antiandrogen seen in clinical practice, the interaction of the two has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::678cb71376182544d1c7e4aa60cad07a
https://doi.org/10.1111/bju.1992.70.5.529
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6
Estrogen and progesterone receptors in ovarian cancer
Autor: R E Leake, M Harding, S Cowan, J Davis, L Cassidy, H Kitchener, David J Hole
Publikováno v: Cancer. 65:486-491
To determine whether steroid hormone receptor expression is clinically relevant in ovarian cancer, cytoplasmic and nuclear estrogen (ER) and progesterone (PR) receptor levels have been measured and their concentration calculated by Scatchard analysis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8902556e12a03f7ebcbdb11224d36147
https://doi.org/10.1002/1097-0142(19900201)65:3<486::aid-cncr2820650319>3.0.co
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7
Local hyperthermia for prostatic disease: in vitro studies on human prostatic cancer cell lines
Autor: S N, Lloyd, D, Chalmers, R E, Leake, D, Kirk
Publikováno v: British journal of urology. 70(5)
Local hyperthermia for benign and malignant prostatic disease remains largely empirical. In an attempt to understand the biological action of hyperthermia, and its potentiation by antiandrogen seen in clinical practice, the interaction of the two has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5bdd1924fa25a8a8c081f202e976174
https://pubmed.ncbi.nlm.nih.gov/1467861
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8
A comparison of biochemical and immunohistochemical assessment of EGFR expression in ovarian cancer
Autor: O J, Owens, C, Stewart, R E, Leake, A M, McNicol
Publikováno v: Anticancer research. 12(5)
The presence of epidermal growth factor receptor (EGFR) was determined both by immunohistochemistry and ligand binding assay in 118 samples from 96 cases of ovarian cancer. EGFR was present in 47.5% of tumours biochemically and in 39.8% of tumours an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c53ee8dd3fe2dfb90a0be79e72a5e5e
https://pubmed.ncbi.nlm.nih.gov/1444207
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9
Transforming growth factor-alpha expression in benign and malignant human prostatic disease
Autor: S N, Lloyd, I L, Brown, R E, Leake
Publikováno v: The International journal of biological markers. 7(1)
Investigation of biological variables in prostatic disease may not only prevent patients with a good prognosis being overtreated, but allow better selection of appropriate therapy, and may identify potential targets for novel therapies. This study in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::394b05aa0898732d14fead58d7632070
https://pubmed.ncbi.nlm.nih.gov/1374784
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10
Side effects of adjuvant tamoxifen
Autor: R E Leake
To investigate the incidence of fatal myocardial infarction in women in the two randomised arms of the Scottish adjuvant tamoxifen trial.Retrospective review of hospital notes to determine with the greatest possible certainty women who had died of an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e013593b017544234b6a62f1f79b9608
https://europepmc.org/articles/PMC1671741/
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