Zobrazeno 1 - 10
of 16
pro vyhledávání: '"R E Haddock"'
Autor:
F. J. Hollis, M. Nash, S. E. Clarke, F. R. Woods, P. C. Shardlow, T. C. Tasker, J. C. Bloomer, R. E. Haddock, G. D. Allen, N. E. Austin, F. C. Higham
Publikováno v:
Xenobiotica. 24:1119-1131
1. The disposition and metabolic fate of 14C-granisetron, a novel 5-HT3 antagonist, was studied in rat, dog, and male human volunteers after intravenous and oral administration. 2. Complete absorption occurred from the gastrointestinal tract followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2af62345c076a81aa6cb2cf22fd6a8
https://doi.org/10.3109/00498259409038671
https://doi.org/10.3109/00498259409038671
Publikováno v:
British Journal of Clinical Pharmacology. 34:262-265
Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs migh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2aea523dae8723473ead72d6c8eb9a6
https://doi.org/10.1111/j.1365-2125.1992.tb04134.x
https://doi.org/10.1111/j.1365-2125.1992.tb04134.x
Publikováno v:
European Journal of Clinical Pharmacology. 54:847-849
To investigate the pharmacokinetics of the pharmacologically active metabolites of sibutramine (metabolites 1 and 2) in healthy young and elderly volunteers following a single oral dose of sibutramine.This was an open, parallel-group study completed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bbcd7d1197a42b9bc8992f8a0cf5b6
https://doi.org/10.1007/s002280050565
https://doi.org/10.1007/s002280050565
Autor:
A R Thawley, H J Kurth, Buscher G, R E Haddock, M A Brett, B Schmerenbeck, W H Greb, E Ellrich, G Rülander
Publikováno v:
Drugs. 40:67-70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794099901a1a78cd676ea03773e35d0a
https://doi.org/10.2165/00003495-199000405-00017
https://doi.org/10.2165/00003495-199000405-00017
Publikováno v:
European Neuropsychopharmacology. 8:S306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd0b090725a693bdc80ca8fa50e5f903
https://doi.org/10.1016/s0924-977x(98)80606-8
https://doi.org/10.1016/s0924-977x(98)80606-8
Publikováno v:
Journal of Pharmacy and Pharmacology. 35:358-362
The penetration of radioactivity into inflamed sites induced by subcutaneously implanted cotton pellets was studied in the rat after oral administration of [14C]nabumetone. Equilibration between inflamed site and plasma concentrations was slow, maxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa7051763f6f54bdc4a6b3b907eb0e3
https://doi.org/10.1111/j.2042-7158.1983.tb02956.x
https://doi.org/10.1111/j.2042-7158.1983.tb02956.x
Publikováno v:
Journal of Medicinal Chemistry. 18:519-523
The metabolic fate of phenprocoumon [3-(alpha-ethylbenzyl)-4-hydroxycoumarin] in the rat is described. The major metabolites, 4',-6-,7-, and 8-hyproxyphenprocoumon, have been identified yb mass spectrometry, TLC, and uv and compared with authentic sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8950813d8cc3c2e6f336e1c5f3c5df
https://doi.org/10.1021/jm00239a017
https://doi.org/10.1021/jm00239a017
Publikováno v:
Chemischer Informationsdienst. 6
Phenprocoumon and all of its aromatic monohydroxylated derivatives have been synthesized and analyzed by TLC, uv, and chemical ionization mass spectroscopy. By utilization of various combinations of these analytical techniques all of the titled compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b0b136be8ca373a8293a93fd292fdd5
https://doi.org/10.1002/chin.197535227
https://doi.org/10.1002/chin.197535227
Publikováno v:
Chemischer Informationsdienst. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459370a158726c82f296f97b3b5f0e07
https://doi.org/10.1002/chin.197535226
https://doi.org/10.1002/chin.197535226
Publikováno v:
Acta psychiatrica Scandinavica. Supplementum. 350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b26abb650a01ad37bf63397c1c6ddca
https://pubmed.ncbi.nlm.nih.gov/2530800
https://pubmed.ncbi.nlm.nih.gov/2530800