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Akademický článek

Peripheral blood marker of residual acute leukemia after hematopoietic cell transplantation using multi-plex digital droplet PCR

Autor: M. Stanojevic, M. Grant, S. K. Vesely, S. Knoblach, C. G. Kanakry, J. Nazarian, E. Panditharatna, K. Panchapakesan, R. E. Gress, J. Holter-Chakrabarty, Kirsten M. Williams

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundRelapse remains the primary cause of death after hematopoietic cell transplantation (HCT) for acute leukemia. The ability to identify minimal/measurable residual disease (MRD) via the blood could identify patients earlier when immunologic i

Externí odkaz: https://doaj.org/article/ffd7a339416943a88f4e11db3a71470d

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Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease

Purpose Progressive malignancy is the leading cause of death after allogeneic hematopoietic stem-cell transplantation (alloHSCT). After alloHSCT, B-cell malignancies often are treated with unmanipulated donor lymphocyte infusions (DLIs) from the tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78731f1c73af0683f0b5eca4e5d2e804
https://europepmc.org/articles/PMC4872017/

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Suppressive effects of recombinant human monokine induced by IFN-gamma (rHuMig) chemokine on the number of committed and primitive hemopoietic progenitors in liquid cultures of CD34+ human bone marrow cells

Autor: G N Schwartz, F Liao, R E Gress, J M Farber

Publikováno v: The Journal of Immunology. 159:895-904

Studies in this report investigated potential hemopoietic suppressive effects of human monokine induced by IFN-gamma (HuMig), a CXC chemokine that is chemotactic for activated lymphocytes. rHuMig was purified from Trichoplusia ni cells after infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::463563f2bfc9bf44dac44457c48afb73
https://doi.org/10.4049/jimmunol.159.2.895

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Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease

Autor: D H Fowler, J Breglio, G Nagel, M A Eckhaus, R E Gress

Publikováno v: The Journal of Immunology. 157:4811-4821

Allogeneic CD8+ T cells mediate both a graft-vs-leukemia (GVL) effect and graft-vs-host disease (GVHD). To evaluate whether CD8 cells of defined cytokine phenotype differentially mediate these processes, alloreactive donor CD8+ T cells preferentially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c7c79273749f484c8ffd9451be9613b
https://doi.org/10.4049/jimmunol.157.11.4811

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Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing

Autor: C L Mackall, C V Bare, L A Granger, S O Sharrow, J A Titus, R E Gress

Publikováno v: The Journal of Immunology. 156:4609-4616

Thymic regenerative capacity in humans decreases with age, suggesting that thymic-independent pathways of T cell regeneration may predominate during adulthood. Using a murine bone marrow transplantation model, we present evidence that thymic-independ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ae78388ae83ba7cb1a4ed6de97dfe69
https://doi.org/10.4049/jimmunol.156.12.4609

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The human anti-murine xenogeneic cytotoxic response. II. Activated murine antigen-presenting cells directly stimulate human T helper cells

Autor: P J Lucas, C V Bare, R E Gress

Publikováno v: The Journal of Immunology. 154:3761-3770

Generation of a human T cell anti-murine xenogeneic response has previously been shown to be dependent on presentation of murine Ag by human APC. We have undertaken a series of experiments to better delineate the cellular defects that prevent effecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce75050a7e98d72604c5ded4556d14e0
https://doi.org/10.4049/jimmunol.154.8.3761

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Immune dysregulation in TGF-beta 1-deficient mice

Autor: M Christ, N L McCartney-Francis, A B Kulkarni, J M Ward, D E Mizel, C L Mackall, R E Gress, K L Hines, H Tian, S Karlsson

Publikováno v: The Journal of Immunology. 153:1936-1946

Approximately 2 wk after birth, mice having a TGF-beta 1 null mutation (TGF-beta 1(-/-)) exhibit a progressive wasting syndrome and death. Associated with this phenotype is a multifocal infiltration of lymphocytes and macrophages into target organs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ace62b18e8d4c26b8b132de19b1b977
https://doi.org/10.4049/jimmunol.153.5.1936

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Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment

Autor: D H Fowler, K Kurasawa, A Husebekk, P A Cohen, R E Gress

Publikováno v: The Journal of Immunology. 152:1004-1013

A murine parent-into-F1 graft-vs-host reaction (GVHR) model that utilizes LPS to induce lethality was used to evaluate the in vivo regulatory role of donor cells of Th2 cytokine phenotype. Transfer of B6 spleen cells into B6C3F1 hosts was lethal when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b18f837a4dfa253c6fe289a2de00f30a
https://doi.org/10.4049/jimmunol.152.3.1004

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Cyclosporine A and peripheral tolerance. Inhibition of veto cell-mediated clonal deletion of postthymic precursor cytotoxic T lymphocytes

Autor: K Hiruma, R E Gress

Publikováno v: The Journal of Immunology. 149:1539-1547

Veto cell-mediated suppression of CTL responses has been proposed as one mechanism by which self tolerance is maintained in mature T cell populations. We have reported that murine bone marrow cells cultured in the presence of high-dose IL-2 (activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b077b77b6e13e488cf32d9a21b9f3c7
https://doi.org/10.4049/jimmunol.149.5.1539

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