Zobrazeno 1 - 10
of 74
pro vyhledávání: '"R E Dornsife"'
Autor:
Christopher R. M. Asquith, Timothy M. Willson, Jonathan M. Elkins, Tuomo Laitinen, P.H.C. Godoi, Carrow I. Wells, Gary L. Johnson, R E Dornsife, Lee M. Graves, Graham J. Tizzard, James M. Bennett, Michael P. East, William J. Zuercher
4-Anilinoquinolines were identified as potent and narrow-spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4-anilino group and the 6,7-quinoline subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9835ce4ce7872ee132ea1d4b5469ec1a
https://eprints.soton.ac.uk/416465/
https://eprints.soton.ac.uk/416465/
Autor:
C. G. Miller, J. A. Onori, Deirdre K. Luttrell, Rakesh Kumar, T. M. Hopper, Kevin Hinkle, Jennifer H. Johnson, I. K. Dev, Robert J. Mullin, K. M. Dold, R. E. Dornsife, Anne T. Truesdale, M. Cheung, Renae M. Crosby, Andrea H. Epperly, Jeffery Alan Stafford, L. E. Harrington
Publikováno v:
British Journal of Cancer
During the development of indazolylpyrimidines as novel and potent inhibitors of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) tyrosine kinase, we observed that some human tumour xenografts are more sensitive to VEGFR2 kinase inhibito
Autor:
Lloyd Frick, John C. Drach, Joseph H. Chan, Dean W. Selleseth, Stanley D. Chamberlain, George W. Koszalka, Ernest H. Dark, Robert J. Harvey, Karen K. Biron, Leroy B. Townsend, R E Dornsife, Michelle G. Davis
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:101-123
A series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94) were synthesized and evaluated for activity against human cytomegalovirus (HCMV) and for cytotoxicity. The 2-subst
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:331-335
Patients infected with the human immunodeficiency virus experienced severe hematopoietic toxicity after treatment with the deoxynucleoside analog 3'-fluorothymidine (FLT). Using several methods for the analysis of genome integrity, including histoche
Autor:
N. A. Van Draanen, Devron Averett, R E Dornsife, R W Jansen, George W. Koszalka, M Tisdale, N R Parry, Joel Van Tuttle
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:868-871
beta-L-2',3'-Dideoxycytidine (beta-L-ddC) and beta-L-5-fluoro-2',3'-dideoxycytidine (5-F-beta-L-ddC) were prepared and shown to have potent activity against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). These compounds were
Autor:
Stanley D. Chamberlain, Devron Averett, R E Dornsife, Lilia M. Beauchamp, George W. Koszalka, Karen K. Biron
Publikováno v:
ChemInform. 25
Autor:
Donald J. Nelson, P A Furman, R E Dornsife, Lloyd Frick, D C Liotta, M T Paff, J A Wurster, James A. Fyfe, L J Wilson, Michelle G. Davis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:2686-2692
The anti-hepatitis B (anti-HBV) activities of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (2'-deoxy-3'-thia-5-fluorocytosine [FTC]) were studied by using an HBV-transfected cell line (HepG2 derivative
Autor:
T J Panella, R E Dornsife, George W. Koszalka, C L Burns, Andrew T. Huang, M H St Clair, Devron Averett
Publikováno v:
Antimicrobial Agents and Chemotherapy. 35:322-328
The anti-human immunodeficiency virus (HIV) activity and hemopoietic toxicity of zidovudine (AZT) and didanosine (dideoxyinosine;ddI), alone and in combination, were assessed in a variety of cell types. AZT was more potent than ddI as an inhibitor of
Autor:
Sylvia C. Stanat, Wayne H. Miller, Leroy B. Townsend, Albert A. Smith, Stanley C. Chamberlain, George W. Koszalka, Robert G. Ferris, Christine L. Talarico, Michelle G. Davis, John C. Drach, Karen K. Biron, Robert J. Harvey, Steven S. Good, R E Dornsife
Human cytomegalovirus (HCMV) is a herpesvirus that causes a benign infection in an estimated 40 to 100% of populations in the United States (reviewed by Sia and Patel [23]). In most cases, HCMV infection is not associated with disease; however, in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5172eb44c5a86b1adc279f6574dae8
https://europepmc.org/articles/PMC127361/
https://europepmc.org/articles/PMC127361/
Autor:
Thomas A. Krenitsky, Steven S. Good, Susan Mary Daluge, J E Reardon, M.B. Faletto, Wayne H. Miller, Devron Averett, M Tisdale, R E Dornsife, M H St Clair, Lawrence R. Boone, N R Parry
Publikováno v:
Antimicrobial agents and chemotherapy. 41(5)
1592U89, (-)-(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclo pentene-1-methanol, is a carbocyclic nucleoside with a unique biological profile giving potent, selective anti-human immunodeficiency virus (HIV) activity. 1592U89 was select