Zobrazeno 1 - 10
of 93
pro vyhledávání: '"R E Counsell"'
Publikováno v:
Journal of Lipid Research, Vol 18, Iss 1, Pp 24-31 (1977)
This paper describes the direct examination of HMG CoA reductase activity in rats treated with 20,25-diazacholesterol. Conversion of acetyl CoA and HMG CoA to mevalonate increased to over 200% of control values in the microsomes and in the 12,000 g s
Externí odkaz:
https://doaj.org/article/dcc9f2880e064e84ac935d339e125c27
Publikováno v:
Pharmaceutical Research. 16:420-426
Purpose. Atherosclerosis is the underlying factor leading to such cardiovascular diseases (CVD) as stroke, aneurysm, and myocardial infarction. The early detection of atherosclerotic plaques is considered to be crucial for successful prevention and/o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e651e418b3bd740fe7bf8b165c35b60
https://doi.org/10.1023/a:1018881904228
https://doi.org/10.1023/a:1018881904228
Publikováno v:
Pharmaceutical research. 3(1)
Radioiodinated cholesteryl iopanoate, a nonhydrolyzable cholesteryl ester probe, showed increased uptake into atherosclerotic aortas of cholesterol-fed rabbits in comparison with normal rabbits. Auto-radiography of the aortas showed the radioactivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5989bb6ecfc8c4698174e41f26dc6ae5
https://pubmed.ncbi.nlm.nih.gov/24271358
https://pubmed.ncbi.nlm.nih.gov/24271358
Autor:
Tanya Djanegara, R. E. Counsell, David E. Schteingart, Linda L. Wotring, Wei Cai, Joseph E. Sinsheimer
Publikováno v:
Journal of Pharmaceutical Sciences. 84:134-138
Mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, o,p'-DDD] is an adrenocorticolytic agent of value in the treatment of adrenocortical carcinoma and Cushing's syndrome. In support of a program to develop agents superior to mitotane,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a9f5a4b57486919a85414cecab8b2d
https://doi.org/10.1002/jps.2600840203
https://doi.org/10.1002/jps.2600840203
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 28:123-136
Baclofen has been found to bind to receptors in the central nervous system that are specific for γ-aminobutyric acid (GABA), a well known inhibitory neurotransmitter. This paper describes the synthesis of a radioiodinated analog of baclofen as part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa279640efd941bbcc6ff09991628d40
https://doi.org/10.1002/jlcr.2580280202
https://doi.org/10.1002/jlcr.2580280202
Autor:
R E, Counsell
Publikováno v:
American journal of therapeutics. 8(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf3e3d2d3976e43fa995589cdb53f6c7
https://pubmed.ncbi.nlm.nih.gov/11550072
https://pubmed.ncbi.nlm.nih.gov/11550072
Publikováno v:
Pharmaceutical research. 16(3)
Atherosclerosis is the underlying factor leading to such cardiovascular diseases (CVD) as stroke, aneurysm, and myocardial infarction. The early detection of atherosclerotic plaques is considered to be crucial for successful prevention and/or therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b336e22428d573cfc48da4a942e3f8e1
https://pubmed.ncbi.nlm.nih.gov/10213374
https://pubmed.ncbi.nlm.nih.gov/10213374
Autor:
M A, Rampy, R S, Brown, A N, Pinchuk, J P, Weichert, R W, Skinner, S J, Fisher, R L, Wahl, M D, Gross, S P, Ethier, R E, Counsell
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 37(9)
Iodine-125-12-[m-iodophenyl]-dodecylphosphocholine (NM-324) has been shown to accumulate in a variety of animal tumor models. Moreover, preliminary pharmacokinetic studies with NM-324 are being conducted in cancer patients. The present study was unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e427fa7d24b5e54056bc42f534937b3c
https://pubmed.ncbi.nlm.nih.gov/8790215
https://pubmed.ncbi.nlm.nih.gov/8790215
Publikováno v:
Pharmaceutical research. 13(6)
A formulation methodology for the incorporation of polyiodinated triglyceride (ITG) analogues into a protein-free chylomicron remnant-like emulsion was developed to provide a vehicle for the selective hepatic delivery of these agents for contrast-enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2c14d80e4f85b6637e97b9908943f02
https://pubmed.ncbi.nlm.nih.gov/8792425
https://pubmed.ncbi.nlm.nih.gov/8792425
Autor:
K P, Plotzke, M A, Rampy, K, Meyer, M, Ruyan, S J, Fisher, R L, Wahl, R W, Skinner, M D, Gross, R E, Counsell
Publikováno v:
Journal of nuclear biology and medicine (Turin, Italy : 1991). 37(4)
The phospholipid ether analog, [125I]-1-O-[12-(m-iodophenyl)dodecyl]propanediol-3-phosphocholine (NM-295) was synthesized and evaluated for its ability to visualize tumors. Preliminary studies were performed in rats bearing the Walker 256 carcinosarc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05c6f1cdd4ee3fc9ea457fb698fd3188
https://pubmed.ncbi.nlm.nih.gov/8172971
https://pubmed.ncbi.nlm.nih.gov/8172971