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Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution

Autor: William J. Cook, R E Parks, Steven E. Ealick, Daniel C. Carter, S A Rule, Y.S. Babu, J Habash, John R. Helliwell, J.D. Stoeckler, Trevor J. Greenhough

Publikováno v: Journal of Biological Chemistry. 265:1812-1820

The three-dimensional structure of human erythrocytic purine nucleoside phosphorylase has been determined at 3.2 A resolution using x-ray diffraction data. Intensity data were measured using radiation from the Synchrotron Radiation Source, Daresbury,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c708e504cc1a71900edec14d39aa152e
https://doi.org/10.1016/s0021-9258(19)40090-2

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Experience with the rapidly renewable lap

Autor: C. J. Evans, R. E. Parks, D. J. Roderick, B. A. Evans

Publikováno v: Optical Fabrication and Testing.

A recent paper1 introduced the concept of the rapidly renewable lap2 and presented some preliminary results. Since then, the additional experience to be described in this presentation indicates that this lap design has advantages both for basic resea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfbb4c456a76adffa463be90acb9f2c2
https://doi.org/10.1364/oft.1996.ofb.2

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Plasma adenosine deaminase2: a marker for human immunodeficiency virus infection

Autor: J G, Niedzwicki, N M, Kouttab, K H, Mayer, C C, Carpenter, R E, Parks, E, Abushanab, D R, Abernethy

Publikováno v: Journal of acquired immune deficiency syndromes. 4(2)

Plasma concentrations of the two isoenzymes of adenosine deaminase (ADA, E.C. 3.5.4.4), adenosine deaminase1 (ADA1) and adenosine deaminase2 (ADA2), were measured in a cohort of ambulatory patients infected with the human immunodeficiency virus (HIV)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::916c5a8c3a541e517e6caf807681510c
https://pubmed.ncbi.nlm.nih.gov/1987354

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5'-deoxy-5'-methylthioadenosine phosphorylase--V. Acycloadenosine derivatives as inhibitors of the enzyme

Autor: T M, Savarese, S, Harrington, C, Nakamura, Z H, Chen, P, Kumar, A, Mikkilineni, E, Abushanab, S H, Chu, R E, Parks

Publikováno v: Biochemical pharmacology. 40(11)

Various adenosine acyclonucleoside derivatives were tested as inhibitors of 5'-deoxy-5'-methylthioadenosine (MeSAdo) phosphorylase, an enzyme involved in the salvage of adenine and methionine from MeSAdo. The 2-halogenated derivatives of acyloadenosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04ffae28410240dda66f24362d03daaa
https://pubmed.ncbi.nlm.nih.gov/2125222

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Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution

Autor: S E, Ealick, S A, Rule, D C, Carter, T J, Greenhough, Y S, Babu, W J, Cook, J, Habash, J R, Helliwell, J D, Stoeckler, R E, Parks

Publikováno v: The Journal of biological chemistry. 265(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4765a59bc105d63e7f0c7767c714da59
https://pubmed.ncbi.nlm.nih.gov/2104852

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Mirrors: Fabrication, Processing, Testing and Tolerances

Autor: R. R. Shannon, M. P. Meinel, A. B. Meinel, R. E. Parks

Publikováno v: International Astronomical Union Colloquium. 79:109-117

The construction of very large telescopes is impeded by very large costs. Much effort is going into finding ways to get below the traditional cost-scaling trend line. We will address several factors that lead to reduction in cost without reduction in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53bd2450fc747b58d4cca9aa7630d54d
https://doi.org/10.1017/s0252921100108309

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Nonenzymatic Glycosylation of Erythrocytic Proteins in Normal and Diabetic Subjects: Enzymes of Nucleoside and Nucleotide Metabolism

Autor: K C Agarwal, John A. Widness, R E Parks, Robert Schwartz

Publikováno v: Diabetes. 34:251-255

A modification of the technique of Glyco-Gel affinity column chromatography has been employed to separate glycosylated proteins from nonglycosylated proteins of hemolysates. When glycosylation in hemolysates of 11 type I diabetic subjects was compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f3319d2997c255ecfb84477c2006a7
https://doi.org/10.2337/diab.34.3.251

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5-Iodoribose 1-phosphate, an analog of ribose 1-phosphate. Enzymatic synthesis and kinetic studies with enzymes of purine, pyrimidine, and sugar phosphate metabolism

Autor: R E Parks, H S Choi, J D Stoeckler

Publikováno v: Journal of Biological Chemistry. 261:599-607

The 5'-deoxy-5'-iodo-substituted analogs of adenosine and inosine are cytotoxic to tumor cells that have high activities of 5'-methylthioadenosine phosphorylase and purine nucleoside phosphorylase, respectively (Savarese, T.M., Chu, S-H., Chu, M.Y.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3daf5496724080055414abb4db270af0
https://doi.org/10.1016/s0021-9258(17)36134-3

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Characterization of a defect in the pathway for converting 5‘-deoxy-5‘-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma

Autor: P C Trackman, R H Abeles, L Y Ghoda, R E Parks, T M Savarese, D L Dexter

Publikováno v: Journal of Biological Chemistry. 259:6715-6719

5'-Deoxy-5'-methylthioadenosine (methylthioadenosine) is cleaved to adenine and 5-methylthioribose-1-phosphate (methylthioribose-1-P). Methylthioribose-1-P is converted to 2-keto-4-methylthiobutyrate ( ketomethylthiobutyrate ) which is transaminated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d739c68d84b71f866280880956988c4
https://doi.org/10.1016/s0021-9258(17)39787-9

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