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Simulation of the cellular oxygen effect with an SV40 DNA model system using DNA strand breaks as an end point

Autor: I S, Ayene, C J, Koch, R E, Krisch

Publikováno v: Radiation research. 146(5)

Most in vitro studies of the modification of radiation damage to DNA by oxygen and reduced thiol compounds have excluded non-thiol .OH scavengers. However, the non-thiol .OH scavengers are known to be very effective radiation protectors and are prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::caacf130e46f7b3999b6e104a0b92ec3
https://pubmed.ncbi.nlm.nih.gov/8896576

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Modification of radiation-induced strand breaks by glutathione: comparison of single- and double-strand breaks in SV40 DNA

Autor: I S, Ayene, C J, Koch, R E, Krisch

Publikováno v: Radiation research. 144(1)

A number of investigations have suggested that the widely observed oxygen enhancement of radiation-induced cell killing or intracellular DNA damage requires the presence of glutathione (GSH) or other thiols. We have adapted an in vitro model system t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc777967327afdc995eb7eb5b82161de
https://pubmed.ncbi.nlm.nih.gov/7568762

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Role of scavenger-derived radicals in the induction of double-strand and single-strand breaks in irradiated DNA

Autor: I S, Ayene, C J, Koch, R E, Krisch

Publikováno v: Radiation research. 142(2)

Studies of intact cells have generally shown a substantial enhancement by oxygen of radiation-induced cell killing or DNA breakage, with an oxygen enhancement ratio (OER) of 2.5-3. Analogous studies of radiation damage to purified DNA in aqueous solu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac234ece2796d8f9ff3750e4ff94abbd
https://pubmed.ncbi.nlm.nih.gov/7724727

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Radiation chemical mechanisms of single- and double-strand break formation in irradiated SV40 DNA

Autor: R E, Krisch, M B, Flick, C N, Trumbore

Publikováno v: Radiation research. 126(2)

Using an electrophoresis assay system developed in our laboratory, we have simultaneously measured single- and double-strand DNA breaks (SSBs and DSBs) induced by gamma radiation in small SV40 viral DNA molecules, under conditions of greatly varying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f067bace077744f5a4175c00f2d3d5f
https://pubmed.ncbi.nlm.nih.gov/1850853

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Enlargement of Escherichia coli After Bacteriophage Infection I. Description of the Phenomenon

Autor: R. E. Krisch, M. L. Freedman

Publikováno v: Journal of Virology. 8:87-94

Escherichia coli B/r and B s−1 ceased division and increased in mean cell volume soon after infection with T-even phage. The effect was obtained with wild-type or rapid lysis mutants, as well as with ultraviolet light-killed phage and with bacterio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99076a34f9d5d0d57c800369261a869f
https://doi.org/10.1128/jvi.8.1.87-94.1971

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DNA breakage, repair, and lethality accompanying 125I decay in microorganisms

Autor: R E, Krisch, F, Krasin, C J, Sauri

Publikováno v: Current topics in radiation research quarterly. 12(1-4)

Effects of 125I decay in DNA were investigated by measurements of strand breaks and lethal efficiencies of the decays. In bacteriophages T1 and T4, local decay effects were compared with effects of the emitted electrons by induction of both single (s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96548be17ebcb2a1e933a49c94e66144
https://pubmed.ncbi.nlm.nih.gov/346313

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Measurement of radiation-induced DNA damage using gel electrophoresis or neutral filter elution shows an increased frequency of DNA strand breaks after exposure to pH 9.6

Autor: M B, Flick, R L, Warters, L S, Yasui, R E, Krisch

Publikováno v: Radiation research. 119(3)

The filter elution technique using nondenaturing conditions is widely used to assay DNA double-strand break (DSB) induction and repair. It has been reported that in the measurement of strand breaks higher rates of elution and of initial rejoining are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5877948195c2e7114be494a8fd612845
https://pubmed.ncbi.nlm.nih.gov/2549560

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A sensitive SV40 viral probe assay for DNA strand breaks and their biological repair in higher cells: techniques and preliminary results

Autor: R E, Krisch, P M, Tan, M B, Flick

Publikováno v: Radiation research. 101(2)

An alternative experimental approach to the investigation of intracellular repair of DNA strand breaks by mammalian higher cells has been developed using simian virus 40 (SV40), which has no known intrinsic DNA repair capacity and possesses a minichr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e7a5392a3367568dff7d1b32e9c739c
https://pubmed.ncbi.nlm.nih.gov/2983363

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