Zobrazeno 1 - 10
of 21
pro vyhledávání: '"R E, Hirsch"'
Publikováno v:
Journal of Biological Chemistry. 271:372-375
Hemoglobin C (Glu beta 6--Lys) shares with hemoglobin S (Glu beta 6--Val) the site of mutation, but with different consequences: deoxyHbS forms polymers, whereas oxyHbC readily forms crystals. The molecular mechanism for this property of oxyHbC is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fb123c349f4519c20b1ada0019b556
https://doi.org/10.1074/jbc.271.1.372
https://doi.org/10.1074/jbc.271.1.372
Autor:
Sarah J. Paquette, Narla Mohandas, David S. Kliger, Daniel B. Shapiro, Robert A. Goldbeck, R. M. Esquerra, Diping Che, R. E. Hirsch
Publikováno v:
Biochemical and Biophysical Research Communications. 205:154-160
The absorption spectra of photolysis intermediates of the CO complex of hemoglobin S and hemoglobin C, in the tetramer form, have been measured between 10 ns and 200 ms after excitation. These data were analyzed using singular value decomposition (SV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b222b2276be7c3ea25d1fedaadc0c0
https://doi.org/10.1006/bbrc.1994.2643
https://doi.org/10.1006/bbrc.1994.2643
Publikováno v:
Biochemical and Biophysical Research Communications. 200:1635-1640
One important criteria for a plasma circulating hemoglobin blood substitute is resistance to subunit dissociation. For this reason, cross-linked hemoglobins (with low oxygen affinities) are being specifically designed to serve as potential blood subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411b10ba6023bed21aa5becfe0eda4bb
https://doi.org/10.1006/bbrc.1994.1639
https://doi.org/10.1006/bbrc.1994.1639
Autor:
Randy W. Larsen, M. D. Chavez, S. H. Courtney, R E Hirsch, M J Lin, Mark R. Ondrias, J M Friedman
Publikováno v:
Journal of Biological Chemistry. 265:4449-4454
Resonance Raman spectroscopy, transient absorption, and fluroescence techniques have been employed to investigate the structure and dynamics of the alpha-cross-linked hemoglobin derivative, HbXL99 alpha. The resonance Raman spectra of the deoxy form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a49c12a630109c74a16c67c2eb715b1
https://doi.org/10.1016/s0021-9258(19)39585-7
https://doi.org/10.1016/s0021-9258(19)39585-7
Publikováno v:
Plant physiology. 127(3)
A reverse genetic strategy was used to isolate Arabidopsis plants containing "knockout" mutations in AKT1 and AKT2, two members of a K+ channel gene family. Comparative studies of growth and membrane properties in wild-type and mutant seedlings were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdca77bd042808f1df8a193c0bc825e0
https://pubmed.ncbi.nlm.nih.gov/11706182
https://pubmed.ncbi.nlm.nih.gov/11706182
Publikováno v:
Proteins. 42(1)
CC individuals, homozygous for the expression of beta(C)-globin, and SC individuals expressing both beta(S) and beta(C)-globins, are known to form intraerythrocytic oxy hemoglobin tetragonal crystals with pathophysiologies specific to the phenotype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca67efc3014d15e54008ae5016d4de9f
https://pubmed.ncbi.nlm.nih.gov/11093264
https://pubmed.ncbi.nlm.nih.gov/11093264
Publikováno v:
Artificial cells, blood substitutes, and immobilization biotechnology. 28(6)
Within the past decade, most research efforts in the red blood cell substitute area have revolved about the development of acellular hemoglobin-based oxygen carriers (HBOC) as clinical replacements and/or augmentation of human blood's carrying and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d94b1985ceea0fd8c53e37bcf0ff837
https://pubmed.ncbi.nlm.nih.gov/11063090
https://pubmed.ncbi.nlm.nih.gov/11063090
Publikováno v:
The Journal of General Physiology
A transferred-DNA insertion mutant of Arabidopsis that lacks AKT1 inward-rectifying K+ channel activity in root cells was obtained previously by a reverse-genetic strategy, enabling a dissection of the K+-uptake apparatus of the root into AKT1 and no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f990184a1e12546b18536debeaca147
https://pubmed.ncbi.nlm.nih.gov/10352038
https://pubmed.ncbi.nlm.nih.gov/10352038
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4)
Recent experimental and epidemiological evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention of colorectal cancer. However, the toxicity associated with the long-term use of most classical NSAIDs has li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b97d60681d5ab2918f8d731ff459cca
https://pubmed.ncbi.nlm.nih.gov/10213222
https://pubmed.ncbi.nlm.nih.gov/10213222
Publikováno v:
Blood. 90(7)
We show here that alpha2(G-Phila.) beta2(C) has an increased rate of crystal nucleation compared to alpha2 beta2(C) (HbC). We conclude from this finding that position alpha68, the mutation site of alpha2(G-Phila.) beta2 (HbG(Philadelphia)), is a cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e55d4c0e5ea3f1e3aaaa4673c0377b90
https://pubmed.ncbi.nlm.nih.gov/9326250
https://pubmed.ncbi.nlm.nih.gov/9326250