Zobrazeno 1 - 10
of 103
pro vyhledávání: '"R E, Handschumacher"'
Publikováno v:
Journal of Applied Crystallography. 28:546-552
The small-angle X-ray scattering (SAXS) technique was used to investigate structural characteristics of the protein cyclophilin in solution and to attempt to detect major changes induced by the binding of the immunosuppressant drug cyclosporin A. Max
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3ae16ed1fe48b5c44db7d419243ff5
https://doi.org/10.1107/s0021889895003268
https://doi.org/10.1107/s0021889895003268
Autor:
Christine Mercier-Bodard, S. Le Bihan, E. R. Sanchez, Etienne-Emile Baulieu, R. E. Handschumacher, Yang-Min Ning, K. Hoffmann, Jack-Michel Renoir
Publikováno v:
Proceedings of the National Academy of Sciences. 92:4977-4981
As previously observed for FK506, we report here that cyclosporin A (CsA) treatment of mouse fibroblast cells stably transfected with the mouse mammary tumor virus-chloramphenicol acetyltransferase (MMTV-CAT) reporter plasmid (LMCAT cells) results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfc33184125641e039c5f49b06a338a
https://doi.org/10.1073/pnas.92.11.4977
https://doi.org/10.1073/pnas.92.11.4977
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe1b3518224d7277efeba4105fb54b1
https://doi.org/10.1002/chin.199501214
https://doi.org/10.1002/chin.199501214
Publikováno v:
Clinical and Experimental Immunology. 90:422-427
SUMMARY Autoantibodies against cyclophilin, a cyclosporin A binding protein, were detected in sera of 29 of 46 (63%) patients with systemic lupus erythematosus and 14 of 40 (35%) Lyme disease patients. The antibodies are directed against the denature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c184d4cb3617b7cbfd23043ca84c5df8
https://doi.org/10.1111/j.1365-2249.1992.tb05862.x
https://doi.org/10.1111/j.1365-2249.1992.tb05862.x
Publikováno v:
Journal of Biological Chemistry. 267:11968-11971
During the purification of eosinophil chemotactic factors synthesized by the uterus in response to estrogen we isolated a protein having an N-terminal (15 amino acids) sequence identical to that of rat cyclophilin. Our data demonstrate that cyclophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f6b0c749f462b9dc56501451aaa09ab
https://doi.org/10.1016/s0021-9258(19)49791-3
https://doi.org/10.1016/s0021-9258(19)49791-3
Autor:
J. R. Vane, R. E. Handschumacher
Publikováno v:
British journal of pharmacology and chemotherapy. 29(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c84dcde09d885e563ecc00bb584798
https://pubmed.ncbi.nlm.nih.gov/19108234
https://pubmed.ncbi.nlm.nih.gov/19108234
Publikováno v:
Journal of General Virology. 71:673-679
The initial velocity of thymidine uptake was measured in HeLa S3 cells infected with herpes simplex virus type 1 (HSV-1). The rate of nucleoside influx into the cells was shown to increase from as early as 1 h post-infection (p.i.) up to 8 h p.i. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0245df867f9f954c0f35845ce7a8908a
https://doi.org/10.1099/0022-1317-71-3-673
https://doi.org/10.1099/0022-1317-71-3-673
Publikováno v:
The Journal of biological chemistry. 276(16)
Uridine phosphorylase (UPase), a key enzyme in the pyrimidine salvage pathway, is associated with the intermediate filament protein vimentin, in NIH 3T3 fibroblasts and colon 26 cells. Affinity chromatography was utilized to purify UPase from colon 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfe691de3aa57cc1c76824ca6ad3bb28
https://pubmed.ncbi.nlm.nih.gov/11278417
https://pubmed.ncbi.nlm.nih.gov/11278417
Publikováno v:
Cancer research. 59(19)
Uridine phosphorylase (UPase) plays an important role in the activation of 5-fluorouracil and in the regulation of tissue and plasma concentration of uridine, a potential biochemical modulator of 5-fluorouracil therapy. UPase expression is affected b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6386445776009d55fdb25ffa493221c8
https://pubmed.ncbi.nlm.nih.gov/10519414
https://pubmed.ncbi.nlm.nih.gov/10519414
Publikováno v:
Cancer research. 58(23)
Uridine phosphorylase (UPase) catalyzes the reversible phosphorolysis of uridine to uracil. We purified the enzyme from the murine colon 26 tumor using a two-step procedure through 5-amino-benzylacyclouridine affinity chromatography. Antibodies raise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d07407bdb94df71d36a1fe852efb8c36
https://pubmed.ncbi.nlm.nih.gov/9850074
https://pubmed.ncbi.nlm.nih.gov/9850074