Zobrazeno 1 - 8
of 8
pro vyhledávání: '"R E, Gammans"'
Autor:
John Sandford, K. J. D'Orlando, R. E. Gammans, Spilios V. Argyropoulos, David J. Nutt, Caroline Bell, A. Rich, Sam Forshall
Publikováno v:
Journal of psychopharmacology (Oxford, England). 15(3)
Pagoclone is a cyclopyrrolone that is believed to act as a partial agonist at the γ-aminobutyric acid (GABA) A/benzodiazepine (BDZ) receptor. In theory, such partial agonists should be anxiolytic but lack the adverse side-effects of sedation, tolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7744956f1e89e21cdd086213101982bd
https://pubmed.ncbi.nlm.nih.gov/11565630
https://pubmed.ncbi.nlm.nih.gov/11565630
Publikováno v:
Neurology. 49(3)
Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. It has been shown to produce beneficial effects in both animal models and non-US clinical stroke trials. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::468a52d36d5ca26df9cc2dd23e717dbb
https://pubmed.ncbi.nlm.nih.gov/9781583
https://pubmed.ncbi.nlm.nih.gov/9781583
Autor:
R E, Gammans, J C, Stringfellow, A J, Hvizdos, R J, Seidehamel, J B, Cohn, C S, Wilcox, L F, Fabre, J C, Pecknold, W T, Smith, K, Rickels
Publikováno v:
Neuropsychobiology. 25(4)
This report presents the results of a retrospective analysis of pooled efficacy data from eight studies in which buspirone was compared to placebo in 520 patients with generalized anxiety disorder (GAD). In addition to evaluating overall efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10212c2c629f4961671c6152a2414b28
https://pubmed.ncbi.nlm.nih.gov/1454160
https://pubmed.ncbi.nlm.nih.gov/1454160
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 25:359-367
Two methods have been developed for the synthesis of tetradeuterated buspirone. Synthesis of the title compound was accomplished by the reaction of 1-(2-pyrimidinyl)piperazine-3,3,5,5-d4 or 1-(2-pyrimidinyl)-piperazine-2,2,3,3,-d4 with 8-(bromobutyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a039e880f74e6881cf270d17a8e538f
https://doi.org/10.1002/jlcr.2580250403
https://doi.org/10.1002/jlcr.2580250403
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 6(3)
Hamster liver microsomes catalyze the N-hydroxylation of the 4'-OCH3, 4'-OCH2CH3, 4'-O(CH2)2CH3, and 4'-O(CH2)3CH3 analogs of trans-4-acetamidostilbene. Other metabolites which were identified were the O-deethylation product of the 4'-OCH2CH3 analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3184d7ab8c358f5a198cbde93131497c
https://pubmed.ncbi.nlm.nih.gov/26541
https://pubmed.ncbi.nlm.nih.gov/26541
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 5(3)
Hamster liver microsomes catalyze the N-hydroxylation of trans-4-acetamidostilbene and its 4'-Cl and 4'-F analogs. Other metabolites which were detected and quantitated were the 4'-OH derivative of trans-4-acetamidostilbene and the glycolamides of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef96003dff3714cf3720aee9b14503b7
https://pubmed.ncbi.nlm.nih.gov/17531
https://pubmed.ncbi.nlm.nih.gov/17531
Autor:
L A, Sternson, R E, Gammans
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 3(4)
Aromatic nitro compounds interact with sodium dithionite-reduced microsomes to generate difference spectra characterized by a maximum at 400 nm and minima at 440 and 528 nm. Spectral binding constants of approximately 1 mM were calculated for ferrohe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1db4e7e4d63a57e9a2a0516c620845d6
https://pubmed.ncbi.nlm.nih.gov/240656
https://pubmed.ncbi.nlm.nih.gov/240656
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