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Pancreatic polypeptide administration improves abnormal glucose metabolism in patients with chronic pancreatitis

Autor: R E Chance, D Elahi, Neal E. Seymour, A S Ryan, F C Brunicardi, Harold E. Lebovitz, Rochelle L Chaiken, Jules A. Hoffmann, Dana K. Andersen, R L Gingerich

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 81:3566-3572

Chronic pancreatitis (CP) is associated with lowered plasma levels and a blunted nutrient-induced release of pancreatic polypeptide (PP). To investigate the possible role of PP on glucose metabolism, we studied male patients with documented CP (n = 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a7ca2fab07b8c8c5d9a3532f38a7cc
https://doi.org/10.1210/jcem.81.10.8855802

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Improving Insulin Therapy: Achievements and Challenges

Autor: R E Chance, J A Galloway

Publikováno v: Hormone and Metabolic Research. 26:591-598

Microvascular complications of diabetes can be forestalled by effective glycemic control. However, the inherent limitations of standard subcutaneous insulins reduce their ability to control glycemia without risk of significant hypoglycemia and hyperi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a574cd219b448ff88b0b29a9ce9c43
https://doi.org/10.1055/s-2007-1001766

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Structural requirements of pancreatic polypeptide receptor binding

Autor: Jones O. Akpan, Katherine M. Leith, Ronald L. Gingerich, Jules A. Hoffmann, R. E. Chance, William R. Gilbert

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 261:E319-E324

Pancreatic polypeptide (PP) receptors have been identified and characterized on the basolateral membranes (BLM) of canine intestinal mucosa. The present study was designed to ascertain the structural requirements of the PP molecule for binding to its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bacf5c2cee10fca2704c97fe2c7e4f5
https://doi.org/10.1152/ajpendo.1991.261.3.e319

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Insulin self-association and the relationship to pharmacokinetics and pharmacodynamics

Autor: M R, DeFelippis, R E, Chance, B H, Frank

Publikováno v: Critical reviews in therapeutic drug carrier systems. 18(2)

The treatment of type 1 diabetes requires multiple, daily injections of insulin. While many improvements involving formulation adjustments have been made in an attempt to optimize therapy, clinical experience indicates that the commercially available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d95a873b4dea7e23ca4b4813690e3933
https://pubmed.ncbi.nlm.nih.gov/11325032

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Sensitive RIA for the specific determination of insulin lispro

Autor: R R, Bowsher, R A, Lynch, P, Brown-Augsburger, P F, Santa, W E, Legan, J R, Woodworth, R E, Chance

Publikováno v: Clinical chemistry. 45(1)

Insulin lispro is an insulin analog in which the primary sequence has been altered by the inversion of amino acids B28 and B29. To date, it has not been possible to specifically measure insulin lispro in the presence of endogenous insulin because of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ada7b5873285d1d391ed982c1c3c3fde
https://pubmed.ncbi.nlm.nih.gov/9895345

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Self-association properties of monomeric insulin analogs under formulation conditions

Autor: J P, Richards, M P, Stickelmeyer, D B, Flora, R E, Chance, B H, Frank, M R, DeFelippis

Publikováno v: Pharmaceutical research. 15(9)

The purpose of the current study was to investigate the effects of two important excipients, zinc and m-cresol, on the self-association properties of a series of monomeric insulin analogs. In this way, the effects on formulation behavior of individua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b015d2c3f5dd661005755a5caafe088
https://pubmed.ncbi.nlm.nih.gov/9755897

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Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor

Autor: D R, Gehlert, D A, Schober, L, Beavers, R, Gadski, J A, Hoffman, D L, Smiley, R E, Chance, I, Lundell, D, Larhammar

Publikováno v: Molecular pharmacology. 50(1)

Traditionally, neuropeptide Y (NPY) receptors have been divided into Y1 and Y2 subtypes based on peptide pharmacology and synaptic localization. Other receptor subtypes have been proposed based on preferences for NPY, peptide YY (PYY), or pancreatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c01fb48c4bfa605fce8a3913f91956fd
https://pubmed.ncbi.nlm.nih.gov/8700103

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