Zobrazeno 1 - 10
of 319
pro vyhledávání: '"R Duchen"'
Autor:
Noemí Esteras, Thomas S. Blacker, Evgeny A. Zherebtsov, Olga A. Stelmashuk, Ying Zhang, W. Christian Wigley, Michael R. Duchen, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102672- (2023)
The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by inducing expression of genes regulating cellular detoxification, antioxidant defence and energy metabolism. Energy production and antioxidant defence employ NADH
Externí odkaz:
https://doaj.org/article/4123d5a1ee434661a0e1f99bf4759861
Autor:
Chih-Yao Chung, Kritarth Singh, Vassilios N. Kotiadis, Gabriel E. Valdebenito, Jee Hwan Ahn, Emilie Topley, Joycelyn Tan, William D. Andrews, Benoit Bilanges, Robert D. S. Pitceathly, Gyorgy Szabadkai, Mariia Yuneva, Michael R. Duchen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Heteroplasmic mtDNA mutations cause disease in humans. Here, Chung et al find the PI3K-Akt-mTORC1 pathway constitutively activated in cells with the heteroplasmic m.3243 A > G mutation, and inhibition of the pathway cell autonomously reduces mutant m
Externí odkaz:
https://doaj.org/article/b9f6630675044451be3ddb118624adeb
Autor:
Andres De La Rossa, Marine H Laporte, Simone Astori, Thomas Marissal, Sylvie Montessuit, Preethi Sheshadri, Eva Ramos-Fernández, Pablo Mendez, Abbas Khani, Charles Quairiaux, Eric B Taylor, Jared Rutter, José Manuel Nunes, Alan Carleton, Michael R Duchen, Carmen Sandi, Jean-Claude Martinou
Publikováno v:
eLife, Vol 11 (2022)
Neuronal excitation imposes a high demand of ATP in neurons. Most of the ATP derives primarily from pyruvate-mediated oxidative phosphorylation, a process that relies on import of pyruvate into mitochondria occuring exclusively via the mitochondrial
Externí odkaz:
https://doaj.org/article/2cd751a48f184191a2992e1ec3ef482e
Autor:
Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F. Brereton, Andrei I. Tarasov, Thomas S. Blacker, Gregor Sachse, Mariana Silva dos Santos, Raul Terron Exposito, Simon Davis, Otto Baba, Roman Fischer, Michael R. Duchen, Patrik Rorsman, James I. MacRae, Frances M. Ashcroft
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a
Externí odkaz:
https://doaj.org/article/e58a88780c484df287e145eadffc1041
Autor:
C. Angélica Pérez-Hernández, Carina C. Kern, Egle Butkeviciute, Elizabeth McCarthy, Hazel M. Dockrell, María Maximina Bertha Moreno-Altamirano, Bruno A. Aguilar-López, Gauri Bhosale, Hongyuan Wang, David Gems, Michael R. Duchen, Steven G. Smith, Francisco Javier Sánchez-García
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Monocytes can develop immunological memory, a functional characteristic widely recognized as innate immune training, to distinguish it from memory in adaptive immune cells. Upon a secondary immune challenge, either homologous or heterologous, trained
Externí odkaz:
https://doaj.org/article/48716dc62ad346e6aba33a1c45c1653e
Autor:
Bruno A. Aguilar-López, María Maximina Bertha Moreno-Altamirano, Hazel M. Dockrell, Michael R. Duchen, Francisco Javier Sánchez-García
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
There is currently some understanding of the mechanisms that underpin the interactions between circadian rhythmicity and immunity, metabolism and immune response, and circadian rhythmicity and metabolism. In addition, a wealth of studies have led to
Externí odkaz:
https://doaj.org/article/edfe68ef870e4cc3be341c027b775b1b
Autor:
Sara Martina Maffioletti, Shilpita Sarcar, Alexander B.H. Henderson, Ingra Mannhardt, Luca Pinton, Louise Anne Moyle, Heather Steele-Stallard, Ornella Cappellari, Kim E. Wells, Giulia Ferrari, Jamie S. Mitchell, Giulia E. Tyzack, Vassilios N. Kotiadis, Moustafa Khedr, Martina Ragazzi, Weixin Wang, Michael R. Duchen, Rickie Patani, Peter S. Zammit, Dominic J. Wells, Thomas Eschenhagen, Francesco Saverio Tedesco
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 899-908 (2018)
Summary: Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including i
Externí odkaz:
https://doaj.org/article/8b22248a00a9498bb213b38f5d00c2e3
Autor:
Marija Sajic, Keila Kazue Ida, Ryan Canning, Norman A. Gregson, Michael R Duchen, Kenneth J Smith
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known. Methods We used in vivo confocal microsc
Externí odkaz:
https://doaj.org/article/c7f7cecb32a34448893157c840643042
Publikováno v:
The EMBO Journal. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8676b26a2b69641f49fa194b6804a785
https://doi.org/10.15252/embj.2023114141
https://doi.org/10.15252/embj.2023114141
Publikováno v:
Trends in Cell Biology. 32:391-405
Mitochondria generate the energy to sustain cell viability and serve as a hub for cell signalling. Their own genome (mtDNA) encodes genes critical for oxidative phosphorylation. Mutations of mtDNA cause major disease and disability with a wide range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8513009c129d3b8ecca87fd352158d68
https://doi.org/10.1016/j.tcb.2021.10.005
https://doi.org/10.1016/j.tcb.2021.10.005