Zobrazeno 1 - 10
of 289
pro vyhledávání: '"R Donatelli"'
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7c495ed76df00defda047352171a57
https://doi.org/10.1158/1535-7163.c.6531858.v1
https://doi.org/10.1158/1535-7163.c.6531858.v1
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb53737462ca7c21b088c7e98afca976
https://doi.org/10.1158/1535-7163.22485255.v1
https://doi.org/10.1158/1535-7163.22485255.v1
Publikováno v:
Medical Research Archives. 9
Background: Intermittent bouts of heavy activity at greater than normal exercise intensity can cause delayed onset muscle soreness (DOMS). Several products are commercially available, all alleging to reduce DOMS. In the present investigation, 40 subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb00e04cee173c7eaa0c7f8cad67c7f0
https://doi.org/10.18103/mra.v9i1.2336
https://doi.org/10.18103/mra.v9i1.2336
Autor:
Christopher J. Molloy, Shelley K. Ballentine, Edward J. Yurkow, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Yanmin Chen, Sanath K. Meegalla, Carl L. Manthey, Mark J. Wall, Bruce E. Tomczuk, Carl R. Illig, Zhao Zhou, Jinsheng Chen, Kenneth J. Wilson, Mark R. Player, Robert R. Donatelli, Margery A. Chaikin
Publikováno v:
Journal of Medicinal Chemistry. 54:7860-7883
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. Early stage absorption,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dea3adaebd4f6f20559806e92e11896f
https://doi.org/10.1021/jm200900q
https://doi.org/10.1021/jm200900q
Autor:
Danielle Lawrence, Yanmin Chen, Mark J. Wall, Carl L. Manthey, Christopher J. Molloy, Edward J. Yurkow, Kenneth J. Wilson, Sanath K. Meegalla, Dana L. Johnson, Carol F. Franks, Bruce E. Tomczuk, Lee Zeng, Shelley K. Ballentine, Baumann Christian Andrew, Zhao Zhou, Judith Baker, Robert R. Donatelli, Lisa Boczon, Carl Crysler, Carl R. Illig, Heidi Ott, Jinsheng Chen, Tuman Robert W, Margery A. Chaikin
Publikováno v:
Molecular Cancer Therapeutics. 8:3151-3161
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1dcd64b489777dd1393ee065709ba7
https://doi.org/10.1158/1535-7163.mct-09-0255
https://doi.org/10.1158/1535-7163.mct-09-0255
Autor:
Jinsheng Chen, Carl L. Manthey, Kenneth J. Wilson, Marie Mazzulla, Margery A. Chaikin, Christopher J. Molloy, Bruce E. Tomczuk, Edward J. Yurkow, Shelley K. Ballentine, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Ioanna Petrounia, Robert R. Donatelli, Carl R. Illig, Lisa Boczon, Sanath K. Meegalla, Mark J. Wall, Raymond J. Patch, Mark R. Player
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2097-2102
A series of 3,4,6-substituted 2-quinolones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). The fully optimized compound, 4-(4-ethyl-phenyl)-3-(2-methyl-3H-imidazol-4-yl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8176b1c0c69b0ad2c4b2f6486901881a
https://doi.org/10.1016/j.bmcl.2008.01.088
https://doi.org/10.1016/j.bmcl.2008.01.088
Autor:
Pierre Raboisson, Raul R. Calvo, Rose Tominovich, Louis V. LaFrance, Karen L. Milkiewicz, Dana L. Johnson, Anna C. Maroney, Shuyuan Zhao, Robert R. Donatelli, Maxwell D. Cummings, Bruce L. Grasberger, Christopher J. Molloy, Tianbao Lu, Juan J. Marugan, Daniel J. Parks, Kristi A. Leonard, Carol F. Franks, Joan Gushue, Holly K. Koblish
Publikováno v:
Molecular Cancer Therapeutics. 5:160-169
The activity and stability of the p53 tumor suppressor are regulated by the human homologue of the mouse double minute 2 (Hdm2) oncoprotein. It has been hypothesized that small molecules disrupting the Hdm2:p53 complex would allow for the activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30835600d455b26ccf94cf87ed7132f4
https://doi.org/10.1158/1535-7163.mct-05-0199
https://doi.org/10.1158/1535-7163.mct-05-0199
Autor:
Shelley K. Ballentine, Edward J. Yurkow, Wall Mark, Carl R. Illig, Mark R. Player, Renee L. DesJarlais, Bruce E. Tomczuk, Zhao Zhou, Carl Crysler, Carsten Schubert, Margery A. Chaikin, Christopher J. Molloy, Kenneth J. Wilson, Robert R. Donatelli, Sanath K. Meegalla, Carl L. Manthey, Yanmin Chen, Chen Jinsheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(23)
Structure-activity relationship (SAR) studies on a highly potent series of arylamide FMS inhibitors were carried out with the aim of improving FMS kinase selectivity, particularly over KIT. Potent compound 17r (FMS IC50 0.7 nM, FMS cell IC50 6.1 nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454fb3a79f9662d8301cbae1328cd7fd
https://pubmed.ncbi.nlm.nih.gov/24138939
https://pubmed.ncbi.nlm.nih.gov/24138939
Autor:
Carl R, Illig, Carl L, Manthey, Mark J, Wall, Sanath K, Meegalla, Jinsheng, Chen, Kenneth J, Wilson, Shelley K, Ballentine, Renee L, Desjarlais, Carsten, Schubert, Carl S, Crysler, Yanmin, Chen, Christopher J, Molloy, Margery A, Chaikin, Robert R, Donatelli, Edward, Yurkow, Zhao, Zhou, Mark R, Player, Bruce E, Tomczuk
Publikováno v:
Journal of medicinal chemistry. 54(22)
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. Early stage absorption,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::beb8da1f3d9cf807908e5dcca5bb958a
https://pubmed.ncbi.nlm.nih.gov/22039836
https://pubmed.ncbi.nlm.nih.gov/22039836
Autor:
Shelley K. Ballentine, Ioanna Petrounia, Yanmin Chen, Carsten Schubert, Sanath K. Meegalla, Bruce E. Tomczuk, Robert R. Donatelli, Christopher J. Molloy, Jinsheng Chen, Margery A. Chaikin, Carl R. Illig, Mark R. Player, Renee L. DesJarlais, Mark J. Wall, Carl Crysler, Kenneth J. Wilson, Carl L. Manthey
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(13)
During efforts to improve the bioavailability of FMS kinase inhibitors 1 and 2, a series of saturated and aromatic 4-heterocycles of reduced basicity were prepared and evaluated in an attempt to also improve the cardiovascular safety profile over lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5510c9a3e081ba95d9c48c2a863b4c
https://pubmed.ncbi.nlm.nih.gov/20570147
https://pubmed.ncbi.nlm.nih.gov/20570147