Zobrazeno 1 - 10
of 46
pro vyhledávání: '"R Demaimay"'
Autor:
Jean-Philippe Deslys, Karim Tarik Adjou, Michel Seman, R Demaimay, F. Lamoury, Dominique Dormont, C I Lasmézas, Vincent Beringue
Publikováno v:
Journal of General Virology. 80:1873-1877
The polyene antibiotic MS-8209 is currently one of the most effective drugs in the treatment of experimental scrapie. However, its mechanism of action and its site of intervention in the pathogenetical process of scrapie infection are largely unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3ea950c5ebfe9e10b1791aabc520d0
https://doi.org/10.1099/0022-1317-80-7-1873
https://doi.org/10.1099/0022-1317-80-7-1873
Publikováno v:
CNS Drugs. 10:83-89
There is currently no effective therapy available for Creutzfeldt-Jakob disease and related prion disorders. However, a limited number of drugs have been found to affect the course of experimental prion diseases and to modify the kinetics of abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b866bcdfae44c97e47021b4519c7a382
https://doi.org/10.2165/00023210-199810020-00001
https://doi.org/10.2165/00023210-199810020-00001
Autor:
Dominique Dormont, M. Seman, Vincent Beringue, Corinne Ida Lasmézas, R Demaimay, Jean-Philippe Deslys, Karim Tarik Adjou, Séverine Demart
Publikováno v:
Scopus-Elsevier
Amphotericin B (AmB) is one of the few drugs able to prolong survival times in experimental scrapie and delays the accumulation of PrPres, a specific marker of this disease in the brain in vivo. Previous reports showed that the AmB effect is observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95771f7a10efe9815614261dc00d0e2
https://doi.org/10.1128/jvi.71.12.9685-9689.1997
https://doi.org/10.1128/jvi.71.12.9685-9689.1997
Publikováno v:
Trends in Microbiology. 5:27-31
Amphotericin B (AmB) is one of the rare drugs that affect the course of experimental prion diseases and modify the kinetics of abnormal prion protein accumulation in the central nervous system. Therefore, AmB could be used as a pharmacological tool t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4498cfffdbf4c59135ef5fcb4976e043
https://doi.org/10.1016/s0966-842x(97)81771-4
https://doi.org/10.1016/s0966-842x(97)81771-4
Autor:
Jean-Philippe Deslys, Karim Tarik Adjou, Dominique Dormont, Vincent Béringue, Michel Seman, Séverine Demart, R Demaimay
Publikováno v:
Annales de l'Institut Pasteur / Actualités. 8:335-341
Aujourd'hui, il n'existe aucun traitement efficace contre les ESST. L'amphotericine B (AmB) fait partie des rares molecules capables de retarder l'apparition des premiers symptomes de la tremblante experimentale. Toutefois, son efficacite est limitee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42e68cdbee156a88e78d69410afb96e
https://doi.org/10.1016/s0924-4204(97)86599-7
https://doi.org/10.1016/s0924-4204(97)86599-7
Autor:
Jean-Philippe Deslys, Karim Tarik Adjou, Jean-Jacques Hauw, Corinne Ida Lasmézas, Dominique Dormont, R Demaimay
Publikováno v:
Journal of General Virology. 77:1601-1609
The development of transmissible spongiform encephalopathies in experimental models depends on two major factors: the intracerebral accumulation of an abnormal, protease-resistant isoform of PrP (PrPres), which is a host protein mainly expressed in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54ed06047fc770176d5f816946b23c
https://doi.org/10.1099/0022-1317-77-7-1601
https://doi.org/10.1099/0022-1317-77-7-1601
Autor:
Jean-Philippe Deslys, Karim Tarik Adjou, Corinne Ida Lasmézas, R Demaimay, C. Lemaire, J. Y. Cesbron, Dominique Dormont, R Rioux, C. Locht
Publikováno v:
Scopus-Elsevier
Using the severe combined immunodeficiency (SCID) mouse model, we investigated the requirement of the immune system for the development of scrapie after peripheral inoculation. A total of 33% of SCID mice, all but one immunologically reconstituted SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3054e207942df9f0e6e2007be5b81f03
https://doi.org/10.1128/jvi.70.2.1292-1295.1996
https://doi.org/10.1128/jvi.70.2.1292-1295.1996
Autor:
Corinne Ida Lasmézas, Jean-Philippe Deslys, Michel Seman, Karim Tarik Adjou, R Demaimay, Dominique Dormont
Publikováno v:
Research in Virology. 147:213-218
Summary Mice were infected intracerebrally with the bovine spongiform encephalopathy (BSE) or the scrapie agent and treated during 8 weeks postinfection to test the protective effect of a new amphotericin B (AmB) derivative, MS-8209, in experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bbfc416b92fc58402db4fe5d04a74b
https://doi.org/10.1016/0923-2516(96)89651-8
https://doi.org/10.1016/0923-2516(96)89651-8
Autor:
R Demaimay, Jean-Philippe Deslys, Karim Tarik Adjou, M. Seman, Corinne Ida Lasmézas, Dominique Dormont
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:2810-2812
To test the efficacy of a new amphotericin B derivative, MS-8209, in delaying scrapie, hamsters were infected intracerebrally with the 263K scrapie agent and treated with MS-8209 either early in the course of the disease or continuously. The results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7944f2533c2fe4e96e9817e9491d5b10
https://doi.org/10.1128/aac.39.12.2810
https://doi.org/10.1128/aac.39.12.2810
Publikováno v:
Archives of virology. Supplementum. (16)
Five compounds related to Congo Red were found to inhibit generation of protease-resistant prion protein in a cell-free system. In this assay Trypan Blue, Evans Blue, Sirius Red F3B, Primuline and Thioflavin-S were all more inhibitory than Congo Red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7b436037fe714e96d51be671f758dc7
https://pubmed.ncbi.nlm.nih.gov/11214931
https://pubmed.ncbi.nlm.nih.gov/11214931