Zobrazeno 1 - 10
of 921
pro vyhledávání: '"R Delaney"'
Autor:
Rupert Dodkins, John R. Delaney, Tess Overton, Frank Scholle, Alba Frias-De-Diego, Elisa Crisci, Nafisa Huq, Ingo Jordan, Jason T. Kimata, Teresa Findley, Ilya G. Goldberg
Publikováno v:
SLAS Technology, Vol 28, Iss 5, Pp 324-333 (2023)
Infectivity assays are essential for the development of viral vaccines, antiviral therapies, and the manufacture of biologicals. Traditionally, these assays take 2–7 days and require several manual processing steps after infection. We describe an a
Externí odkaz:
https://doaj.org/article/4164547a60cb4c38aeed8c84f6d42e6f
Autor:
Charles Brobbey, Shasha Yin, Liu Liu, Lauren E. Ball, Philip H. Howe, Joe R. Delaney, Wenjian Gan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and symmetric di-methylation on arginine residues and has emerged as a potential antitumor target with inhibitors being tested in clinical trials. However, it remains un
Externí odkaz:
https://doaj.org/article/00e13b111bd54ef681b39bbe57020209
Autor:
Joe R. Delaney, Albert R. La Spada
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102205- (2023)
Summary: Translocation sequencing can be used to assess mechanisms of DNA repair and identify genome-wide double-strand breaks (DSBs) accessible to DNA repair machinery. Here, we present a protocol for mapping double-strand DNA break sites across the
Externí odkaz:
https://doaj.org/article/3893213cd32147d9bb4d691062c1dc10
Autor:
Lily L. Wong, Christina G. Bruxvoort, Nicholas I. Cejda, Matthew R. Delaney, Jannette Rodriguez Otero, David J. Forsthoefel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Lipid metabolism regulates stem cell states and differentiation. Here, the authors demonstrate a requirement in planarians for Apolipoprotein B-mediated neutral lipid transport from intestinal stores to stem cells and their progeny during differentia
Externí odkaz:
https://doaj.org/article/1e5027e1b8fb46e9980387d043d0b68a
Autor:
Robert R. Bowers, Maya F. Andrade, Christian M. Jones, Shai White-Gilbertson, Christina Voelkel-Johnson, Joe R. Delaney
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells (PGCCs). These cells form under the stress of chemotherapy and have higher than diploid chromosom
Externí odkaz:
https://doaj.org/article/54b64f90c5764688a4aa650cce72a63e
RAC‐ing up tumour stemness: Disabled homolog 2 interacting protein and triple‐negative breast cancer
Autor:
Joe R Delaney
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 1, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/3fae40e152ea4e2596d618b07defc2c9
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The corneal epithelium is continuously subjected to external stimuli that results in varying degrees of cellular damage. The use of live-cell imaging approaches has facilitated understanding of the cellular and molecular mechanisms underlying the cor
Externí odkaz:
https://doaj.org/article/920290f0013449c19e15b59cb95afa15
Autor:
Mohamad Motaharinia, Kim Gerrow, Roobina Boghozian, Emily White, Sun-Eui Choi, Kerry R. Delaney, Craig E. Brown
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Stroke profoundly disrupts cortical excitability which impedes recovery, but how stroke affects inhibitory interneurons is poorly understood. Here, the authors show that functional impairments after stroke are associated with the disruption of a high
Externí odkaz:
https://doaj.org/article/50a3bfd6ed7e47fe8b042711c5a38eb5
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Background: Combination therapy of targeted drugs in cancer treatment is a field in constant flux, with research balancing side effects with efficacy. Efficacy from combination therapy is improved either through synthetic lethality or through prevent
Externí odkaz:
https://doaj.org/article/72c0965e96cc400ca0990bd1d903b97c
Autor:
Shai White‐Gilbertson, Ping Lu, Christian M. Jones, Stephanie Chiodini, Deborah Hurley, Arabinda Das, Joe R. Delaney, James S. Norris, Christina Voelkel‐Johnson
Publikováno v:
Cancer Medicine, Vol 9, Iss 9, Pp 3142-3152 (2020)
Abstract Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence. PGCC have the pote
Externí odkaz:
https://doaj.org/article/d1f6ae005b2e4bb4b8b54ea700442373