Impact of antibody framework residue VH-71 on the stability of a humanised anti-MUC1 scFv and derived immunoenzyme

Autor: Julie Richards, R Darbha, Dianne L. Newton, Bang K. Vu, Xinhua Ji, M. P. Deonarain, N S Courtenay-Luck, Juergen Krauss, Michaela A. E. Arndt, Susanna M. Rybak, Z Zhu, V Choudhry

Publikováno v: British Journal of Cancer

Anti-MUC1 single-chain Fv (scFv) fragments generated from the humanised antibody huHMFG1 had adequate antigen-binding properties but very poor stability irrespective of the applied linker or domain orientation. Mutagenesis of heavy-chain framework re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28165432427a4c7a35f4ace546594fed
https://doi.org/10.1038/sj.bjc.6601759

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Clinical genomicist workstation.

Autor: Sharma MK; Dept. of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO;, Phillips J, Agarwal S, Wiggins WS, Shrivastava S, Koul SB, Bhattacharjee M, Houchins CD, Kalakota RR, George B, Meyer RR, Spencer DH, Lockwood CM, Nguyen TT, Duncavage EJ, Al-Kateb H, Cottrell CE, Godala S, Lokineni R, Sawant SM, Chatti V, Surampudi S, Sunkishala RR, Darbha R, Macharla S, Milbrandt JD, Virgin HW, Mitra RD, Head RD, Kulkarni S, Bredemeyer A, Pfeifer JD, Seibert K, Nagarajan R

Publikováno v: AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science [AMIA Jt Summits Transl Sci Proc] 2013 Mar 18; Vol. 2013, pp. 156-7. Date of Electronic Publication: 2013 Mar 18 (Print Publication: 2013).