Zobrazeno 1 - 10
of 56
pro vyhledávání: '"R Dale Brown"'
Autor:
Danielle R Bruns, Philip D Tatman, Roshni S Kalkur, R Dale Brown, Kurt R Stenmark, Peter M Buttrick, Lori A Walker
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220573 (2019)
RationaleIn virtually all models of heart failure, prognosis is determined by right ventricular (RV) function; thus, understanding the cellular mechanisms contributing to RV dysfunction is critical. Whole organ remodeling is associated with cell-spec
Externí odkaz:
https://doaj.org/article/4b5c61dd88c746749ef7939aab96ddac
Autor:
R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R. Stenmark
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 324:H804-H820
Using a large animal model and employing a comprehensive approach integrating hemodynamic, transcriptomic, proteomic, and immunohistochemical analyses, we examined the early (2 wk) effects of severe PH on the RV. We observed that RV remodeling during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e426dd05eb030a8846d9667ad5f8d584
https://doi.org/10.1152/ajpheart.00614.2022
https://doi.org/10.1152/ajpheart.00614.2022
Autor:
Spiekerkoetter, Vitaly O. Kheyfets, Sushil Kumar, Paul M. Heerdt, Kenzo Ichimura, R. Dale Brown, Melissa Lucero, Ilham Essafri, Sarah Williams, Kurt R. Stenmark, Edda
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9746
This study analyzed microarray data of right ventricular (RV) tissue from rats exposed to pulmonary embolism to understand the initial dynamic transcriptional response to mechanical stress and compare it with experimental pulmonary hypertension (PH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::dfa4f0b904ad59fd8ec34b27a12ef34a
Autor:
Greta M. Krafsur, Joseph M. Neary, Franklyn Garry, Timothy Holt, Daniel H. Gould, Gary L. Mason, Milton G. Thomas, R. Mark Enns, Rubin M. Tuder, Michael P. Heaton, R. Dale Brown, Kurt R. Stenmark
Publikováno v:
Pulmonary Circulation, Vol 9 (2019)
The obesity epidemic in developed societies has led to increased cardiovascular diseases including pulmonary hypertension associated with left heart disease (PH-LHD), the largest and fastest-growing class of PH. Similar to obese humans, PH and heart
Externí odkaz:
https://doaj.org/article/440dfeb8daf044be9bebb2ecdcdb36eb
Autor:
Nzali V. Campbell, Claudia Mickael, Sushil Kumar, Hui Zhang, Ian L. Campbell, Austin E. Gillen, Caio O. Trentin, Katrina Diener, Bifeng Gao, Vitaly O. Kheyfets, Sue Gu, Rahul Kumar, Tzu Phang, R. Dale Brown, Brian B. Graham, Kurt R. Stenmark
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(1)
Few studies have examined lung interstitial macrophage (IM) molecular phenotypes after being exposed to hypoxia in vivo at the single-cell level, even though macrophages contribute to hypoxic pulmonary hypertension (PH). We aimed to determine IM dive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6441b1f277093bf31bb5e0201d111f
https://pubmed.ncbi.nlm.nih.gov/35608266
https://pubmed.ncbi.nlm.nih.gov/35608266
Autor:
R. Dale Brown, Kaysie J Jennings, Timothy N. Holt, Kurt R. Stenmark, R Mark Enns, Greta M. Krafsur, S.J. Coleman, Scott E Speidel, Milton G Thomas
Publikováno v:
Translational Animal Science
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ccf700ec293668cf82689966eb10ad
https://doi.org/10.1093/tas/txz052
https://doi.org/10.1093/tas/txz052
Autor:
Hui Zhang, Angelo D'Alessandro, Kirk C. Hansen, Subhash Chandra Yadav, Sushil Kumar, Min Li, Monika Dzieciatkowska, Micaela K Roy, Maria G. Frid, Kurt R. Stenmark, R. Dale Brown, Suzette R. Riddle
Publikováno v:
JCI Insight
Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by complement-dependent, fibroblast-induced perivascular accumulation and proinflammatory activation of macrophages. We hypothesized that, in PH, nanoscale-sized small extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175ece36b248e14e21b6e3b3f054b60a
https://doi.org/10.1172/jci.insight.148382
https://doi.org/10.1172/jci.insight.148382
Publikováno v:
Hypoxic Respiratory Failure in the Newborn ISBN: 9780367494018
Hypoxic Respiratory Failure in the Newborn
Hypoxic Respiratory Failure in the Newborn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a83fa212f01626b21f38684bec43c1ea
https://doi.org/10.1201/9780367494018-20
https://doi.org/10.1201/9780367494018-20
Autor:
Tanya J. Applegate, Greta M. Krafsur, June A. Boon, Hui Zhang, Min Li, Timothy N. Holt, S. Kelly Ambler, Benjamin A. Abrams, Daniel L. Gustafson, Karsten Bartels, Franklyn B. Garry, Kurt R. Stenmark, R. Dale Brown
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and leading to right ventricular hypertrophy, failure, and death. We hypothesized that targeting chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b6479c3836592e7be3a2b7c761b584
https://doi.org/10.3389/fphys.2021.712583
https://doi.org/10.3389/fphys.2021.712583
Autor:
Andrea L. Frump, François Potus, Diana M. Tabima, Bakhtiyor Yakubov, Steeve Provencher, Junichi Omura, Kurt R. Stenmark, Valérie Nadeau, Kathy J. Krentz, Marjorie Albrecht, Todd G. Cook, Rongbo Li, Eve Tremblay, R. Dale Brown, Sébastien Bonnet, Tim Lahm, Amanda Fisher, Brooke H Rodriguez, Xin Sun, Sandra Breuils-Bonnet, Naomi C. Chesler, C. Dustin Rubinstein
Publikováno v:
The Journal of clinical investigation, vol 131, iss 6
J Clin Invest
J Clin Invest
Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d9cef2749864fb6eb97bb7641427ae
https://doi.org/10.1172/jci129433
https://doi.org/10.1172/jci129433