Zobrazeno 1 - 10
of 12
pro vyhledávání: '"R D Salter"'
Publikováno v:
The Journal of Immunology. 149:136-142
The alpha 1 and alpha 2 domains of the class I MHC molecule constitute the putative binding site for processed peptides and the TCR, although the alpha 3 domain has been implicated as a binding site for the CD8 molecule. Species specificity in the bi
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(10)
Increased levels of agalactosyl IgG (G0 IgG) are found in several autoimmune diseases, including rheumatoid arthritis, in which they are correlated with severity of the disease. To investigate whether structural alteration of IgG may lead to aberrant
Autor:
Q, Zhang, R D, Salter
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(2)
Calnexin is a lectin-like chaperone that binds to class I MHC molecules soon after their synthesis, retaining unassembled heavy chains and also assisting their folding. Following association with beta2-microglobulin (beta2m) in the endoplasmic reticu
Publikováno v:
Cancer research. 57(17)
Prostate-specific antigen (PSA) has been demonstrated to release the active form of insulin-like growth factor I in vitro (P. Cohen et al., J. Clin. Endocrinol.Metab., 75: 1046-1053, 1992; P. Cohen et al., J. Clin. Endocrinol.Metab., 79: 1410-1415, 1
Publikováno v:
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. 14(2)
A novel method was developed to isolate immunogenic peptides (CD8+ T-cell epitopes) from class I complexes expressed at the cell surface of viable cells. Cells treated at pH 3.3 with citrate-phosphate buffer for periods as short as 15 s remained viab
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 149(4)
We have previously shown that the capacity of class I molecules to confer resistance to NK in transfected target cells maps to the Ag-binding site (ABS) of the HLA class I structure. Here we examine the effect of peptide (reagents specific for the AB
Publikováno v:
Scopus-Elsevier
The crystal structure of the HLA-Aw68.1 antigen binding site revealed a negatively charged pocket centred on aspartic acid 74 (Garrett et al. 1989). Access to this '74 pocket' is blocked in HLA-Aw68.2 and HLA-Aw69 by two substitutions at positions 97
Publikováno v:
The Journal of Immunology. 142:306-311
Genes encoding the serologically cross-reactive HLA-B51 and HLA-Bw52 molecules were isolated and the exons sequenced. HLA-B51 genes obtained from Caucasian and Oriental individuals were identical. HLA-Bw52 differs from HLA-B51 by four nucleotide subs
Autor:
P Cresswell, R D Salter
Publikováno v:
The EMBO journal. 5(5)
Biosynthesis of HLA class I antigens has been studied in a variant B-LCLxT-LCL hybrid, 174XCEM.T2. This cell line encodes HLA-A2 and -B5, but expresses only small amounts of A2 antigen and undetectable B5 antigen at the cell surface due to a mutation
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 138(6)