Zobrazeno 1 - 10
of 51
pro vyhledávání: '"R D Hawkins"'
Autor:
J. Mathieu, D. Detraux, D. Kuppers, Y. Wang, C. Cavanaugh, S. Sidhu, S. Levy, A. M. Robitaille, A. Ferreccio, T. Bottorff, A. McAlister, L. Somasundaram, F. Artoni, S. Battle, R. D. Hawkins, R. T. Moon, C. B. Ware, P. J. Paddison, H. Ruohola-Baker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN)
Externí odkaz:
https://doaj.org/article/d50b9ac4e8764f89b3e5badb92229b82
Autor:
R. D. Hawkins, Todd M. Smith, N. Doni Jayavelu, Jessica C. Mar, Stephanie L. Battle, Bo Yu, Timothy Schimmel, Samuel E. Zimmerman, Jacques Cohen
Oocyte maturation is a coordinated process that is tightly linked to reproductive potential. A better understanding of gene regulation during human oocyte maturation will not only answer an important question in biology, but also facilitate the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198d88b0f2e50ebcef2c5ef81484e935
Autor:
Julie Mathieu, Logeshwaran Somasundaram, Hannele Ruohola-Baker, Sonia B. Sidhu, Aaron M. Robitaille, A. McAlister, T. Bottorff, Damien Detraux, Randall T. Moon, Filippo Artoni, R. D. Hawkins, Daniel A. Kuppers, Patrick J. Paddison, Amy Ferreccio, Carol B. Ware, Christopher Cavanaugh, Shiri Levy, Yuliang Wang, Stephanie L. Battle
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mathieu, J, Detraux, D, Kuppers, D, Wang, Y, Cavanaugh, C, Sidhu, S, Levy, S, Robitaille, A M, Ferreccio, A, Bottorff, T, McAlister, A, Somasundaram, L, Artoni, F, Battle, S, Hawkins, R D, Moon, R T, Ware, C B, Paddison, P J & Ruohola-Baker, H 2019, ' Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency ', Nature Communications, vol. 10, no. 1, 632, pp. 632 . https://doi.org/10.1038/s41467-018-08020-0
Nature Communications
Mathieu, J, Detraux, D, Kuppers, D, Wang, Y, Cavanaugh, C, Sidhu, S, Levy, S, Robitaille, A M, Ferreccio, A, Bottorff, T, McAlister, A, Somasundaram, L, Artoni, F, Battle, S, Hawkins, R D, Moon, R T, Ware, C B, Paddison, P J & Ruohola-Baker, H 2019, ' Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency ', Nature Communications, vol. 10, no. 1, 632, pp. 632 . https://doi.org/10.1038/s41467-018-08020-0
Nature Communications
To reveal how cells exit human pluripotency, we designed a CRISPR-Cas9 screen exploiting the metabolic and epigenetic differences between naïve and primed pluripotent cells. We identify the tumor suppressor, Folliculin(FLCN) as a critical gene requi
Publikováno v:
International Journal of Sports Medicine. 34:302-311
The validity and reliability of a battery of field-based performance tests was examined. The opinions of coaches, fitness professionals and players (n=170, 172 and 101 respectively) on the importance of performance testing were established using a qu
Publikováno v:
British Journal of Sports Medicine. 35:43-47
To undertake a prospective epidemiological study of the injuries sustained in English professional football over two competitive seasons.Player injuries were annotated by club medical staff at 91 professional football clubs. A specific injury audit q
Autor:
Colin W. Fuller, R D Hawkins
Publikováno v:
Safety Science. 27:115-128
Professional football clubs have a duty under UK health and safety legislation to carry out risk assessments of their activities; one requirement under this duty is to assess the impact of ground layout on player safety. To assist clubs in meeting th
Publikováno v:
NeuroReport. 5:1033-1036
Nitric oxide (NO) has been suggested to play the role of retrograde messenger during long-term potentiation (LTP) in hippocampus. In support of this idea, NO induces LTP when paired with a weak tetanus (50 Hz). An additional criterion that has been p
Publikováno v:
Learning & Memory. 1:243-257
A hallmark of many forms of classical conditioning is a precise temporal specificity: Learning is optimal when the conditioned stimulus (CS) slightly precedes the unconditioned stimulus (US), but the learning is degraded at longer or backward interva
Autor:
Kara E. Powder, Mark E. Warchol, Stavros Bashiardes, Yuan-Chieh Ku, David M. Alvarado, Meghan K Spriggs, Rose Veile, Michael Lovett, Judith D. Speck, R. D Hawkins
Sensory hair cells of the inner ear are the mechanoelectric transducers of sound and head motion. In mammals, damage to sensory hair cells leads to hearing or balance deficits. Nonmammalian vertebrates such as birds can regenerate hair cells after in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4934053ed637565bd8102bbd5fe05d69
https://europepmc.org/articles/PMC3086586/
https://europepmc.org/articles/PMC3086586/
Autor:
R D, HAWKINS
Publikováno v:
University of Toronto medical journal. 23