Zobrazeno 1 - 10
of 45
pro vyhledávání: '"R D Christen"'
Publikováno v:
British Journal of Cancer
To determine the role of p53 protein on the cellular effects of amifostine, we used molecularly engineered HCT116 colon cancer cells in which the p53 gene was inactivated by targeted homologous recombination or p53 protein was degraded by high-level
Publikováno v:
Molecular Pharmacology. 60:1153-1160
Cisplatin (cDDP) is effective against some human tumors, but many are intrinsically resistant and, even among initially sensitive tumors, acquired resistance develops commonly during treatment. It has not been possible to prove which biochemical mech
Publikováno v:
Head & Neck. 23:860-870
Background Growing evidence suggests that tobacco can affect the responsiveness of cancer cells to treatment, particularly those of head and neck cancer. This article describes the effects of nicotine on the signaling of the death pathway, resulting
Publikováno v:
Cancer Chemotherapy and Pharmacology. 47:397-403
Purpose: Activation of the epidermal growth factor (EGF) receptor has previously been shown to increase the sensitivity of cancer cells to DNA-damaging agents, including cisplatin, UV-B, and γ-radiation. We now investigated the mechanisms by which E
Autor:
Q Zhang, G Sellakumar, P Varadarajan, Xinjian Lin, Alissar Nehmé, R. Hannes Niedner, M Gerhold, R D Christen
Publikováno v:
British Journal of Cancer
We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, and that the nature of the interaction between ATRA and docetaxel was highly synergistic. Docetaxel-induced apoptotic cel
Publikováno v:
British Journal of Cancer
DNA damage has been shown to activate c-Abl tyrosine kinase. We now report that, in addition to DNA damage, microtubule damage induced by paclitaxel results in activation of c-Abl kinase. In 3T3 cells, the presence of c-Abl kinase increased paclitaxe
Autor:
Steven C. Plaxe, D Fink, Dennis D. Heath, Stephen B. Howell, M M de las Alas, Stefan Aebi, Saeeda Kirmani, Gerrit Los, D. Darrah, T. W. Schnider, Edward F. McClay, R D Christen, Horacio B. D'Agostino
Publikováno v:
Cancer Chemotherapy and Pharmacology. 44:259-265
Purpose: The purpose of this study was to investigate the effect of high-dose progesterone, an inhibitor of P glycoprotein, on the pharmacokinetics and toxicity of paclitaxel. Patients and methods: A total of 29 patients with various tumors were trea
Autor:
Stefan Aebi, Stephen B. Howell, Glenn J. Bubley, D Fink, Beverly A. Teicher, Bruno Cenni, R D Christen, H K Kim
Publikováno v:
British Journal of Cancer
In addition to recognizing and repairing mismatched bases in DNA, the mismatch repair (MMR) system also detects cisplatin DNA adducts and loss of MMR results in resistance to cisplatin. A comparison was made of the ability of MMR-proficient and -defi
Publikováno v:
British journal of cancer, vol 76, iss 7
British Journal of Cancer
British Journal of Cancer
hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstr
Autor:
R Sanga, J. A. Jones, Relef Kroning, R D Christen, Gerrit Los, Stephen B. Howell, D K Hom, C C Chuang
Publikováno v:
British Journal of Cancer
We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenograf