Výsledky vyhledávání - "R D Blumenthal"

Tumor-specific dose scheduling of bimodal radioimmunotherapy and chemotherapy

Autor: R D, Blumenthal, E, Leone, D M, Goldenberg

Publikováno v: Anticancer research. 23(6C)

Radioimmunotherapy (RAIT) has been shown to enhance the efficacy of chemotherapy in a variety of tumor models. When multiple drugs are available for a given tumor type, several questions arise, such as how one selects the appropriate drug to be used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c2a1ae40665ef63942fb978452c9dbf
https://pubmed.ncbi.nlm.nih.gov/14981904

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Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts

Autor: R D, Blumenthal, C, Waskewich, D M, Goldenberg, W, Lew, C, Flefleh, J, Burton

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)

Inhibition of the enzyme cyclooxygenase with celecoxib is cytotoxic in a variety of solid tumor cell lines. Previous work has shown that by charting circadian rhythms, it has been possible to find optimal times to deliver a dose of drug, such that it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b0a0c09ed95b9c9f5fab5a8b361f3ae
https://pubmed.ncbi.nlm.nih.gov/11595712

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Cure of metastatic human colonic cancer in mice with radiolabeled monoclonal antibody fragments

Autor: T M, Behr, R D, Blumenthal, S, Memtsoudis, R M, Sharkey, S, Gratz, W, Becker, D M, Goldenberg

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(12)

There is currently no method to cure patients with disseminated colorectal cancer, which is the third leading cancer killer in the Western World. This report shows that the GW-39 intrapulmonary micrometastatic human colonic cancer model in nude mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c7cc118ac089bfd444cd110a1e5087b
https://pubmed.ncbi.nlm.nih.gov/11156250

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Plasma FLT3-L levels predict bone marrow recovery from myelosuppressive therapy

Autor: R D, Blumenthal, W, Lew, M, Juweid, R, Alisauskas, Z, Ying, D M, Goldenberg

Publikováno v: Cancer. 88(2)

During the recovery period after anticancer myelosuppressive therapy, hematopoietic progenitor cells become mitotically active in order to replenish the bone marrow compartment and remain hyperproliferative even after normalization of peripheral whit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::415237d5e31417165bf1748c6d11f91e
https://pubmed.ncbi.nlm.nih.gov/10640965

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Studies on the red marrow dosimetry in radioimmunotherapy: an experimental investigation of factors influencing the radiation-induced myelotoxicity in therapy with beta-, Auger/conversion electron-, or alpha-emitters

Autor: T M, Behr, G, Sgouros, M G, Stabin, M, Béhé, C, Angerstein, R D, Blumenthal, C, Apostolidis, R, Molinet, R M, Sharkey, L, Koch, D M, Goldenberg, W, Becker

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5

Usually, the red marrow (RM) is the first dose-limiting organ in radioimmunotherapy. However, several studies have obtained only poor correlations between the marrow doses and the resulting toxicities. Furthermore, RM doses are mostly not determined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c171ee888c56344ada50676a58580b56
https://pubmed.ncbi.nlm.nih.gov/10541340

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Importance of timing of radioimmunotherapy after granulocyte colony-stimulating factor administration for peripheral blood stem cell harvest

Autor: M E, Juweid, R D, Blumenthal, W, Lew, G, Hajjar, A D, Rubin, D M, Goldenberg

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5

Nine radioimmunotherapy (RAIT)-naive patients with medullary thyroid cancer received high doses of 131I-MN-14 F(ab)2 anti-carcinoembryonic antigen monoclonal antibody (232-486 mCi), five in combination with bone marrow harvest, without prior granuloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50213ce959230bbedd1e0d94ce9f530b
https://pubmed.ncbi.nlm.nih.gov/10541383

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Radioimmunotherapy of small volume disease of colorectal cancer metastatic to the liver: preclinical evaluation in comparison to standard chemotherapy and initial results of a phase I clinical study

Autor: T M, Behr, A L, Salib, T, Liersch, M, Béhé, C, Angerstein, R D, Blumenthal, A, Fayyazi, R M, Sharkey, B, Ringe, H, Becker, B, Wörmann, W, Hiddemann, D M, Goldenberg, W, Becker

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5

At the time of surgery, occult metastases (micrometastases) are present in more than 50% of colorectal cancer patients, and the liver is the most frequent site of apparent metastatic disease. Frequently, adjuvant chemotherapy is unable to prevent tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d4cda7543f19d67b59dd55675601652
https://pubmed.ncbi.nlm.nih.gov/10541369

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Prediction of hematologic toxicity after radioimmunotherapy with (131)I-labeled anticarcinoembryonic antigen monoclonal antibodies

Autor: M E, Juweid, C H, Zhang, R D, Blumenthal, G, Hajjar, R M, Sharkey, D M, Goldenberg

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(10)

This study was undertaken to determine the factors affecting myelotoxicity after radioimmunotherapy (RAIT) with 131I-labeled anticarcinoembryonic antigen (anti-CEA) monoclonal antibodies (MAbs).Ninety-nine patients who received 131I-labeled MN-14 or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::948ec74bfaa32cce46de8374f3257bbe
https://pubmed.ncbi.nlm.nih.gov/10520699

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