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Effect of bis(benzyl)polyamine derivatives on polyamine transport and survival ofBrugia pahangi

Autor: R. D. Walter, P. P. McCann, S. Müller, A. Lüchow

Publikováno v: Parasitology Research. 77:612-615

A potent filaricidal effect of bis(benzyl)polyamine derivatives is reported; the addition of 1 microM MDL 27695 to Brugia pahangi maintained in vitro killed the worms within 1 week. Using the labelled derivative, MDL 27391 uptake was demonstrated and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379af82fc778667451f4b3803659f8fe
https://doi.org/10.1007/bf00931024

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[[1]Benzothieno[3,2-b]pyridin-4-yl-amine--synthesis and investigation of activity against malaria]

Autor: K, Görlitzer, H, Meyer, R D, Walter, H, Jomaa, J, Wiesner

Publikováno v: Die Pharmazie. 59(7)

The ethyl 4-chlorobenzothieno[3,2-b]pyridine-3-carboxylate (2) reacted with the hydrochlorides of the mono- and bis-phenol Mannich bases 6 to yield the amodiaquine and pyronaridine analogues 9. The chloroquine analogue 10 was formed by melting 2 with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1ca358de030f6ab30e471e20ad74de6
https://pubmed.ncbi.nlm.nih.gov/15297995

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