Zobrazeno 1 - 10
of 32
pro vyhledávání: '"R D, Verschoyle"'
Publikováno v:
Toxicology and Applied Pharmacology. 123:193-198
Inhibition of pulmonary CYP4B1 activity by pretreatment of rats with p-xylene decreased the ability of lung microsomes to N-hydroxylate 2-aminofluorene and prevented the lung damage normally seen after dosing with ipomeanol. The toxicity of ipomeanol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb4f4c6b06bbb98704e368513fb869f
https://doi.org/10.1006/taap.1993.1237
https://doi.org/10.1006/taap.1993.1237
Publikováno v:
Toxicological Sciences. 18:79-88
The insect repellent DEET and the structurally related herbicide diphenamid both cause ataxia associated with a spongi-form myelinopathy largely confined to the cerebellar roof nuclei. This local myelinopathy was accompanied by the formation of neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edecabd878996b344301c4030b4941e
https://doi.org/10.1093/toxsci/18.1.79
https://doi.org/10.1093/toxsci/18.1.79
Autor:
R D, Verschoyle, D, Dinsdale
Publikováno v:
Environmental Health Perspectives
Protection afforded by trialkyl phosphorothionates against the lung injury caused by trialkyl phosphorothiolates probably results from the inhibition by the P = S moiety of the thionates, of one or more pulmonary cytochrome P-450 isozymes. The aromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0fca153048ff5307e886291c19de99
https://doi.org/10.1289/ehp.85-1568337
https://doi.org/10.1289/ehp.85-1568337
Autor:
R A, Sharma, C R, Ireson, R D, Verschoyle, K A, Hill, M L, Williams, C, Leuratti, M M, Manson, L J, Marnett, W P, Steward, A, Gescher
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5)
Curcumin prevents colon cancer in rodent models. It inhibits lipid peroxidation and cyclooxygenase-2 (COX-2) expression and induces glutathione S-transferase (GST) enzymes. We tested the hypothesis that 14 days of dietary curcumin (2%) affects biomar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afe61499bd53d09dd1d73aea5682a32b
https://pubmed.ncbi.nlm.nih.gov/11350917
https://pubmed.ncbi.nlm.nih.gov/11350917
Autor:
D, Dinsdale, R D, Verschoyle
Publikováno v:
Biochemical pharmacology. 61(4)
This study was designed to test the hypothesis that the reduction in cytochrome P450 (CYP) 2B1 content and activity of rat lung microsomes, following dosing with pneumotoxic trimethylphosphorothioates, results from damage to specific cell types. Of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc5628431023add9c798e6cfcaeb2e23
https://pubmed.ncbi.nlm.nih.gov/11226384
https://pubmed.ncbi.nlm.nih.gov/11226384
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 27(8)
1. Selective induction and inhibition experiments have been used to identify the cytochrome P450 (CYP) isoforms responsible for butylated hydroxytoluene (BHT) bioactivation in mouse lung. 2. Pre-treatment of BALB/c mice with O,O,O-trimethylphosphorot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649b1e85fa99c92576b89af5478044cc
https://pubmed.ncbi.nlm.nih.gov/9293621
https://pubmed.ncbi.nlm.nih.gov/9293621
Publikováno v:
Toxicology and applied pharmacology. 122(2)
In rats, 1-nitronaphthalene (1-NN) causes both pulmonary and hepatic toxicity. Pulmonary toxicity is evident as bronchiolar damage, with necrosis of Clara cells and ciliated cells, whereas hepatic injury involves vacuolation of centrilobular hepatocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd74a84f54253051e4ebb5291fe6d60
https://pubmed.ncbi.nlm.nih.gov/8212003
https://pubmed.ncbi.nlm.nih.gov/8212003
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(2)
O,O,S-Trimethylphosphorothioate and methylcyclopentadienyl manganese tricarbonyl damage the type I pneumocytes of the alveolar epithelium in rats. Butylated hydroxytoluene causes similar damage in mice. The toxicity of these compounds is dependent on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79a356f3476450acdcf5f5d29dd47081
https://pubmed.ncbi.nlm.nih.gov/8355217
https://pubmed.ncbi.nlm.nih.gov/8355217
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(1)
The O-dealkylation of pentoxyresorufin, a substrate for P450 2B1, was decreased in lung microsomes from rats dosed with O,O,S-trimethylphosphorodithioate, O,O,O-trimethylphosphorothioate, bromophos, fenitrothion, p-xylene and 2,4-dichloro-(6-phenylph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f25a1c0b73e6829eab6d4855a0764b0
https://pubmed.ncbi.nlm.nih.gov/8474020
https://pubmed.ncbi.nlm.nih.gov/8474020
Publikováno v:
Neuropathology and Applied Neurobiology. 13:55-69
Triethyltin causes an increase in brain water with vacuolation of myelin sheaths, whereas trimethyltin is selectively damaging to neurons, especially of the hippocampal formations, causing chromatolysis, accumulation of cytoplasmic dense bodies and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb1c5ad1d5adbfbaf291e10f05b125f
https://doi.org/10.1111/j.1365-2990.1987.tb00170.x
https://doi.org/10.1111/j.1365-2990.1987.tb00170.x