Zobrazeno 1 - 10
of 49
pro vyhledávání: '"R D, Spealman"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Heroin has characteristic subjective effects that contribute importantly to its widespread abuse. Drug discrimination procedures in animals have proven to be useful models for investigating pharmacological mechanisms underlying the subjective effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::855b8e6c24e507eb332d096ddb018efa
https://pubmed.ncbi.nlm.nih.gov/11602692
https://pubmed.ncbi.nlm.nih.gov/11602692
Publikováno v:
Experimental and clinical psychopharmacology. 8(3)
Drug discrimination procedures have been used to study receptor mechanisms of benzodiazepine (BZ) agonists with the goal of developing new therapeutic agents that retain positive effects of conventional BZ ligands yet have reduced side effects. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ed31f66051db82f77384351bac06af5
https://pubmed.ncbi.nlm.nih.gov/10975618
https://pubmed.ncbi.nlm.nih.gov/10975618
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(2)
Dopaminergic mechanisms are thought to be critical in mediating relapse to cocaine-seeking behavior. This study examined the different roles of D1- and D2-like receptor mechanisms in the relapse process. Squirrel monkeys were given extended histories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3114ca9a1478ba5e899d89bc931e4f9e
https://pubmed.ncbi.nlm.nih.gov/10900248
https://pubmed.ncbi.nlm.nih.gov/10900248
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(3)
Previous studies suggest that D1 receptor partial agonists may be viable candidates for development as pharmacotherapies for cocaine addiction. This study investigated the ability of the D1 receptor partial agonists SKF 83959 and SKF 77434 to modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b30187bf97580c83e530db669f570e8
https://pubmed.ncbi.nlm.nih.gov/10869406
https://pubmed.ncbi.nlm.nih.gov/10869406
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(3)
The present study examined whether zolpidem, an imidazopyridine with selectivity for benzodiazepine (BZ)/gamma-aminobutyric acid(A) receptors containing the alpha1-subunit, had discriminative stimulus effects similar to typical BZs and other sedative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66ac4ad8a0d76d7ed079c3b954bbb436
https://pubmed.ncbi.nlm.nih.gov/10565847
https://pubmed.ncbi.nlm.nih.gov/10565847
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
Morphine and other mu opioids mimic and/or modulate the discriminative stimulus (DS) effects of cocaine, possibly reflecting mutual stimulation of mesolimbic dopamine activity. Less is known about the capacity of cocaine and related stimulants to mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17128563085c6a8ce078398abd569884
https://pubmed.ncbi.nlm.nih.gov/10454482
https://pubmed.ncbi.nlm.nih.gov/10454482
Autor:
R D, Spealman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(3)
Dopamine agonists and antagonists varying in affinity and selectivity at the D3 subtype of D2-like receptors were studied in squirrel monkeys trained to discriminate cocaine from vehicle in a two-lever choice procedure. In drug substitution experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8abfe808c9f077f489aae380d61b15ba
https://pubmed.ncbi.nlm.nih.gov/8819495
https://pubmed.ncbi.nlm.nih.gov/8819495
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(3)
Dopamine agonists that reportedly differ in intrinsic activity at dopamine D1 receptors were compared for their behavioral effects in squirrel monkeys responding under a fixed-ration schedule of reinforcement. When administered alone, all drugs produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a40e28239a2fc395c2c4c0d5fb898596
https://pubmed.ncbi.nlm.nih.gov/8786574
https://pubmed.ncbi.nlm.nih.gov/8786574
Autor:
R D, Spealman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(1)
Noradrenergic involvement in the discriminative stimulus (DS) effects of cocaine was investigated in squirrel monkeys by using a two-lever drug discrimination procedure in which responding was maintained by a fixed-ratio schedule of stimulus-shock te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::256c7abbddb0499881435725e8f192b9
https://pubmed.ncbi.nlm.nih.gov/7562595
https://pubmed.ncbi.nlm.nih.gov/7562595
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(2)
Dose-response functions for selected N-methyl-D-aspartate (NMDA) antagonists and direct and indirect dopamine agonists were compared in rats trained to discriminate either a low (2 mg/kg) or a high (10 mg/kg) dose of cocaine from vehicle. The NMDA-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c29cd46ee62e16a01c39efdf2bcaf79f
https://pubmed.ncbi.nlm.nih.gov/7636725
https://pubmed.ncbi.nlm.nih.gov/7636725