Zobrazeno 1 - 10
of 16
pro vyhledávání: '"R D, Murdoch"'
Autor:
B D, Zussman, L J, Benincosa, D M, Webber, D J, Clark, H, Cowley, J, Kelly, R D, Murdoch, J, Upward, P, Wyld, A, Port, H, Fuder
Publikováno v:
Journal of Clinical Pharmacology. 41:950-958
The oral pharmacokinetics of cilomilast (Ariflo) were investigated in five separate studies in healthy volunteers. Cilomilast was rapidly absorbed, and pharmacokinetics were dose proportional after single and repeat dosing. The elimination half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5a460d2258105132c97ef93da1e507
https://doi.org/10.1177/00912700122010924
https://doi.org/10.1177/00912700122010924
Autor:
Robert S. Dawe, R. P. Marshall, James Ferguson, F. M. Muller, Ana R. Sousa, S. M. McHugh, R. D. Murdoch, Brian Sanderson
Publikováno v:
Photodermatology, photoimmunologyphotomedicine. 25(3)
Background: The anti-inflammatory potency of topical dermatological corticosteroids in suppressing ultraviolet (UV) erythema is routinely measured. No such model exists to assess the potency of systemically administered steroids. Objective: To determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2ac69b8bc36740d6cf3e938d51c5c0
https://pubmed.ncbi.nlm.nih.gov/19438993
https://pubmed.ncbi.nlm.nih.gov/19438993
Autor:
R D Murdoch, Graham W. Clarke, Domenico Spina, C L Ledbetter, Brian J. O'Connor, J C Denyer, M J Hurle, David E. Simcock, J E Coote, Clive P. Page, T J Savage, R A Brown
Publikováno v:
The European respiratory journal. 31(2)
Asthmatics, unlike healthy subjects, experience bronchoconstriction in response to inhaled adenosine, and extracellular adenosine concentrations are elevated in the bronchoalveolar lavage fluid and exhaled breath condensate of asthmatic subjects. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f757dad617bf856fd7b8e5123bfb30
https://pubmed.ncbi.nlm.nih.gov/17959644
https://pubmed.ncbi.nlm.nih.gov/17959644
Publikováno v:
Clinical therapeutics. 23(6)
Background: Cilomilast is an orally active, selective phosphodiesterase 4 inhibitor currently in clinical development for the treatment of chronic obstructive pulmonary disease. Objective: The purpose of this study was to examine the tolerability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71b56eebdc2bcaecd73af58fe61994a
https://pubmed.ncbi.nlm.nih.gov/11440291
https://pubmed.ncbi.nlm.nih.gov/11440291
Publikováno v:
British journal of clinical pharmacology. 35(2)
1. Increased histamine concentrations are found in the plasma and urine following allergen challenge in allergic subjects. This study compared a controlled challenge with clinically relevant doses of inhaled and injected histamine, as indicative of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a97b21860214bd429fa6d7f149f4c3
https://pubmed.ncbi.nlm.nih.gov/8443035
https://pubmed.ncbi.nlm.nih.gov/8443035
Publikováno v:
Clinical oncology (Royal College of Radiologists (Great Britain)). 3(5)
Radiotherapy-induced emesis is poorly controlled with existing antiemetics. 5-Hydroxytryptamine (5HT3) receptor antagonists are a new class of antiemetics which have been demonstrated to be effective in controlling cytotoxic-induced emesis. We have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c531d6dca65165bb2f4c6ec7ba9583
https://pubmed.ncbi.nlm.nih.gov/1657114
https://pubmed.ncbi.nlm.nih.gov/1657114
Publikováno v:
Agents and actions. 32(3-4)
Five subjects with a recent history of urticaria (U), five atopic (A) subjects and a non-atopic (NA) control group were given intravenous infusions of histamine starting at 0.05 micrograms/kg/min, increasing by 0.05 micrograms/kg/min every 30 minutes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48417a1d7844513ffb939c86323e015
https://pubmed.ncbi.nlm.nih.gov/1907427
https://pubmed.ncbi.nlm.nih.gov/1907427
Publikováno v:
Occupational and Environmental Medicine. 43:37-43
All 306 South African platinum refinery workers (116 white, 190 coloured) accepted for employment on grounds of absence of evidence of atopy were investigated using the skin prick test and RAST to detect sensitivity to platinum, palladium, and rhodiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb9142ad062c3ecc6540f35e5c5d14d
https://doi.org/10.1136/oem.43.1.37
https://doi.org/10.1136/oem.43.1.37
Publikováno v:
Clinical Experimental Allergy. 17:181-189
Summary A microassay has been developed to measure histamine release from both washed human leucocytes and whole blood, in which blood samples can be diluted down to 1:20 without affecting their sensitivity to antigen. The sensitivity and reproducibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8337ca20507aacd4ab053abf0312923d
https://doi.org/10.1111/j.1365-2222.1987.tb02002.x
https://doi.org/10.1111/j.1365-2222.1987.tb02002.x
Publikováno v:
Journal of the Royal College of Physicians of London. 21(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39ec0aa15ea12d8edfdca7371edaf39f
https://pubmed.ncbi.nlm.nih.gov/2445986
https://pubmed.ncbi.nlm.nih.gov/2445986