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Akademický článek

Anti-Inflammatory Properties of Exenatide in Human Pancreatic Islets

Autor: S. R. Cechin, I. Pérez-Álvarez, E. Fenjves, R. D. Molano, A. Pileggi, P-O. Berggren, C. Ricordi, R. L. Pastori Ph.D.

Publikováno v: Cell Transplantation, Vol 21 (2012)

Exenatide is an analog of the incretin hormone glucagon-like peptide (GLP-1) that is used for the treatment of T2D for their metabolic effects. In addition to its insulinotropic effects, exenatide increases functional islet mass and improves their su

Externí odkaz: https://doaj.org/article/83db0f1ab9064c8da6fed01474ffc7db

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Akademický článek

Evaluation of Viable β-Cell Mass is Useful for Selecting Collagenase for Human Islet Isolation: Comparison of Collagenase NB1 and Liberase HI

Autor: R. Misawa, C. Ricordi, A. Miki, S. Barker, R. D. Molano, A. Khan, S. Miyagawa, L. Inverardi, R. Alejandro, A. Pileggi, H. Ichii M.D., Ph.D.

Publikováno v: Cell Transplantation, Vol 21 (2012)

The selection of enzyme blend is critical for the success of human islet isolations. Liberase HI collagenase (Roche) was introduced in the 1990s and had been widely used for clinical islet transplantation. More recently, a blend collagenase NB1 has b

Externí odkaz: https://doaj.org/article/d1323388c03d4d579ba77727ff0aa62b

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Stable perfluorocarbon emulsions for the delivery of halogenated ether anesthetics

Autor: Behrouz Ashrafi, R. D. Molano, Phillip Ruiz, Christopher A. Fraker, Ernesto A. Pretto, Mohammad Hossein Tootoonchi, Ryan Bardsley

Publikováno v: Colloids and Surfaces B: Biointerfaces. 172:797-805

Background Research into injectable volatile anesthetics has been ongoing for approximately 40 years, with limited success, in an attempt to address the deficiencies of inhalational anesthesia. The purpose of this work was to formulate and optimize v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9c71aaf9aee2b85219e896680143f2
https://doi.org/10.1016/j.colsurfb.2018.09.024

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Akademický článek

Antiproinflammatory Effects of Iodixanol (OptiPrep)-Based Density Gradient Purification on Human Islet Preparations

Autor: A. Mita, C. Ricordi, S. Messinger, A. Miki, R. Misawa, S. Barker, R. D. Molano, R. Haertter, A. Khan, S. Miyagawa, A. Pileggi, L. Inverardi, R. Alejandro, B. J. Hering, H. Ichii M.D., Ph.D.

Publikováno v: Cell Transplantation, Vol 19 (2010)

Islet isolation and purification using a continuous density gradient may reduce the volume of tissue necessary for implantation into patients, therefore minimizing the risks associated with intraportal infusion in islet transplantation. On the other

Externí odkaz: https://doaj.org/article/9c4bc89c77554fe4afe203954ac206a4

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Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

Autor: Camillo Ricordi, T Yamamoto, R. D. Molano, Antonello Pileggi, Ryosuke Misawa, Atsushi Miki, Atsuyoshi Mita, Nosratola D. Vaziri, Hirohito Ichii, Yasunaru Sakuma

Publikováno v: PLoS ONE
Miki, A; Ricordi, C; Sakuma, Y; Yamamoto, T; Misawa, R; Mita, A; et al.(2018). Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation. PLOS ONE, 13(5), e0196570. doi: 10.1371/journal.pone.0196570. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/78t5q3cb
PLoS ONE, Vol 13, Iss 5, p e0196570 (2018)

Author(s): Miki, Atsushi; Ricordi, Camillo; Sakuma, Yasunaru; Yamamoto, Toshiyuki; Misawa, Ryosuke; Mita, Atsuyoshi; Molano, Ruth D; Vaziri, Nosratola D; Pileggi, Antonello; Ichii, Hirohito | Abstract: BackgroundType 1 and Type 2 diabetes mellitus (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09546e21c53038631a336773564976b3
http://europepmc.org/articles/PMC5933778

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Islet Cell Transplantation: In Vivo and in Vitro Functional Assessment of Nonhuman Primate Pancreatic Islets

Autor: N Cautero, R. D. Molano, Rodolfo Alejandro, Norma S. Kenyon, Luca Inverardi, Alessandra Ranuncoli, Michele Masetti, Camillo Ricordi

Publikováno v: Scopus-Elsevier
Europe PubMed Central
Cell Transplantation, Vol 9 (2000)

Transplantation of pancreatic islets of Langerhans as a therapeutic approach for treatment of type I diabetes offers an alternative to subcutaneous insulin injections. Normalization of blood glucose levels by transplanted islets may prevent the devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979cc06fc145cfc75e8c230264332a9b
https://pubmed.ncbi.nlm.nih.gov/28880659

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Influence of In Vitro and In Vivo Oxygen Modulation on β Cell Differentiation From Human Embryonic Stem Cells

Autor: Susana Villate, Camillo Ricordi, R. D. Molano, Christopher A. Fraker, Antonello Pileggi, Silvia Álvarez-Cubela, Luca Inverardi, Sirlene Cechin, Jaime A. Giraldo, Juan Domínguez-Bendala

Publikováno v: Stem Cells Translational Medicine. 3:277-289

The possibility of using human embryonic stem (hES) cell-derived β cells as an alternative to cadaveric islets for the treatment of type 1 diabetes is now widely acknowledged. However, current differentiation methods consistently fail to generate me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e884e894662cf9076c87fba9e4e55b
https://doi.org/10.5966/sctm.2013-0160

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Correction of Diabetes Mellitus by Transplanting Minimal Mass of Syngeneic Islets Into Vascularized Small Intestinal Segment

Autor: Antonello Pileggi, Manana Kakabadze, Camillo Ricordi, R. D. Molano, Ekaterine Berishvili, G Loladze, Zurab Kakabadze, G Shatirishvili, Konstantine Mardaleishvili, Sanjeev Gupta

Publikováno v: American Journal of Transplantation, Vol. 13, No 10 (2013) pp. 2550-2557

Transplantation of mature islets into portal vein has been most effective thus far, although attrition of transplanted islets constitutes a major limitation, and alternative approaches are required. We analyzed the mechanisms by which islets engrafte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1a67899d2e5fa48fd4eee9ef90bdb9
https://doi.org/10.1111/ajt.12412

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Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

Autor: Paola Maffi, Antonello Pileggi, Domenico Corradi, Sara Tezza, R. D. Molano, Francesca D'Addio, Francesca Gatti, Paolo Fiorina, Melissa Chin, Mohamed H. Sayegh, Carmen Fotino, Antonio Secchi, Fabio Grassi, Maria Elena Ferrero, Rita Gatti, Andrea Vergani, Camillo Ricordi, Michele Podetta, Roberto Bassi

Publikováno v: Diabetes

The lymphocytic ionotropic purinergic P2X receptors (P2X1R-P2X7R, or P2XRs) sense ATP released during cell damage-activation, thus regulating T-cell activation. We aim to define the role of P2XRs during islet allograft rejection and to establish a no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e576e568193c7f58b5423e3bf68496
http://europepmc.org/articles/PMC3636636

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