Výsledky vyhledávání

Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles

Autor: F J, Brown, Y K, Yee, L A, Cronk, K C, Hebbel, R D, Krell, D W, Snyder

Publikováno v: Journal of Medicinal Chemistry. 33:1771-1781

A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305ab18c51918a3a73d0e1d9c722664f
https://doi.org/10.1021/jm00168a036

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Protective and risk influences of drug use among a multiethnic sample of adolescent boys

Autor: Elisha R. Galaif, Michael D. Newcomb, W. A. Vega, R. D. Krell

Publikováno v: Journal of drug education. 37(3)

A measurement model was analyzed to demonstrate a differential distribution and cumulative exposure to psychosocial risk and protective influences of adolescent drug use among ethnically-diverse adolescent samples. The sample included U.S.-born (US)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f197da28fd6aeb4e2f7c5fc333da0f94
https://pubmed.ncbi.nlm.nih.gov/18047182

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Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate)

Autor: C. K. Buckner, David J. Lengel, Edward J. Kusner, Christopher J. DeHaas, Joseph C. Williams, R D Krell

Publikováno v: Annals of the New York Academy of Sciences. 744

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd1a77103979d46ff9848c5f57f1b31
https://pubmed.ncbi.nlm.nih.gov/7825851

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Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig

Autor: C K, Buckner, N, Liberati, D, Dea, D, Lengel, C, Stinson-Fisher, J, Campbell, S, Miller, A, Shenvi, R D, Krell

Publikováno v: The Journal of pharmacology and experimental therapeutics. 267(3)

This study has examined the abilities of (+/-)-CP96345 and (+/-)-SR48968, nonpeptide antagonists selective for the tachykinin NK1 and NK2 receptors, respectively, to block bronchoconstriction caused by intravenous administration of direct-acting rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b051bed9040deb39010c23b13d4c113e
https://pubmed.ncbi.nlm.nih.gov/8263778

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Characterization of bradykinin receptors in guinea pig gall bladder

Autor: R C, Falcone, S J, Hubbs, J D, Vanderloo, J C, Prosser, J, Little, B, Gomes, D, Aharony, R D, Krell

Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(3)

Specific binding of [3H]bradykinin (BK) to guinea pig gall bladder (GPGB) membranes was protein dependent, rapid (Kon = 0.067 min-1) with high affinity (Kd = 0.45 +/- 0.02; n = 3), saturable (Bmax = 546 +/- 56 fmol/mg of protein) and showed no cooper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a9ed2cc2a1e0bfc2e68d40fc29ef594
https://pubmed.ncbi.nlm.nih.gov/8396632

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Status of leukotriene antagonists and other modulators of lipid mediators

Autor: R D, Krell, R E, Giles

Publikováno v: Agents and actions. Supplements. 41

This communication briefly summarizes the available clinical findings with several eicosanoid antagonists or synthesis inhibitors in human models of asthma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::420fee1a81220b7b3bf0a4960b657495
https://pubmed.ncbi.nlm.nih.gov/8317342

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