Výsledky vyhledávání - "R D, Goldfien"

NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium

Autor: J C Ryan, E C Niemi, R D Goldfien, J C Hiserodt, W E Seaman

Publikováno v: The Journal of Immunology. 147:3244-3250

NKR-P1 is a 60-kDa homodimer expressed on all rat NK cells. Previous studies by others suggest that NKR-P1 may play a role in NK cell activation because antibody to NKR-P1 stimulates the release of granules from NK cells, and anti-NKR-P1 causes redir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b38712c7619f11952c493cfc806b9ca4
https://doi.org/10.4049/jimmunol.147.9.3244

Zobrazit plný text záznamu

Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line

Autor: R D Goldfien, W E Seaman, W M Hempel, J B Imboden

Publikováno v: The Journal of Immunology. 146:3703-3708

Ligand-induced activation of T cells results in stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC). A structurally diverse family of PI-PLC isoforms has recently been defined, and more than one isoform is frequently coexpressed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66d4d5b3b36db999f53f00c15594ef22
https://doi.org/10.4049/jimmunol.146.11.3703

Zobrazit plný text záznamu

Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling

Autor: A S Pollock, William E. Seaman, E C Niemi, M R Stark, R D Goldfien, John B. Imboden

Publikováno v: The Journal of Experimental Medicine

We have previously shown that in vitro culture of rat natural killer (NK) cells in high concentrations of recombinant interleukin 2 (rIL-2) leads to the expression of a surface glycoprotein with a molecular mass of approximately 42 kD. This glycoprot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e50ea2f20da912649ee8d9bd1594ec5
http://europepmc.org/articles/PMC2118766

Zobrazit plný text záznamu

Genetic analysis of human B cell hybridomas expressing a cross-reactive idiotype

Autor: R D Goldfien, P J Chen, T J Kipps, G Starkebaum, J G Heitzmann, V Radoux, S Fong, D A Carson

Publikováno v: The Journal of Immunology. 138:940-944

We have examined the genetic basis for the expression of a human cross-reactive idiotype (CRI) commonly found on monoclonal IgM rheumatoid factors. The CRI was identified with a monoclonal antibody (17.109) and has been localized previously to the ka

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ccd6f63f59bcb30b360a86a2ce0ca96
https://doi.org/10.4049/jimmunol.138.3.940

Zobrazit plný text záznamu

Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype

Autor: Sherman Fong, D A Carson, R D Goldfien, Pojen P. Chen

Publikováno v: The Journal of Experimental Medicine

Synthetic peptides corresponding to eight individual heavy chain complementarity-determining regions (CDR) of three human monoclonal IgM anti-IgG (rheumatoid factor [RF]) paraproteins elicited rabbit antibodies with markedly different properties. All

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ff8b7e2cec1cdee88b7bf8639e7099
https://doi.org/10.1084/jem.162.2.756

Zobrazit plný text záznamu

Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins

Autor: J J Crowley, R D Goldfien, R E Schrohenloher, H L Spiegelberg, G J Silverman, R A Mageed, R Jefferis, W J Koopman, D A Carson, S Fong

Publikováno v: The Journal of Immunology. 140:3411-3418

The basis for rheumatoid factor (RF) production in autoimmune or lymphoproliferative diseases cannot be understood without defining the molecular factors that dictate RF structure and specificity. Recently three different mAb (6B6.6, 17.109, and G6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e6a625fd87654faaa0314983e809745
https://doi.org/10.4049/jimmunol.140.10.3411

Zobrazit plný text záznamu

Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans

Autor: Pojen P. Chen, Blas Frangione, Royston Jefferis, R D Goldfien, Rizgar A. Mageed, Gregg J. Silverman, S. Fong, Fernando Goni, Dennis A. Carson

Rheumatoid factors (RFs) in humans have been studied intensively because of their association with autoimmune and lymphoproliferative diseases. Many human IgM-RFs express cross-reactive idiotypes (CRIs) and have homologous light chains, some of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aab85735c6f4781637902672705dc2c
https://europepmc.org/articles/PMC303536/

Zobrazit plný text záznamu

Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors)

Autor: D A, Carson, P P, Chen, T J, Kipps, V, Radoux, F, Jirik, R D, Goldfien, R I, Fox, G J, Silverman, S, Fong

Publikováno v: Ciba Foundation symposium. 129

High titres of anti-IgG autoantibodies (rheumatoid factors, RF) are characteristic of patients with rheumatoid arthritis, Sjögren's syndrome, and mixed cryoglobulinaemia, and may contribute to immune complex formation and tissue damage. The monoclon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9d3bd9a6ef9e2df99f72113edc65a7e
https://pubmed.ncbi.nlm.nih.gov/3315499

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání