Zobrazeno 1 - 10
of 27
pro vyhledávání: '"R D, Burgoyne"'
Publikováno v:
The Biochemical journal.
Caseins and many other secretory proteins are phosphorylated during their transport through the secretory pathway by a protein kinase present within Golgi compartments. Molecular analysis of the Golgi casein kinase (GCK) has not been possible since i
Autor:
R D, Burgoyne, J S, Duncan
Publikováno v:
Journal of mammary gland biology and neoplasia. 3(3)
Mammary epithelial cells secrete milk proteins in a polarized manner from their apical surface during lactation. These secreted proteins are either synthesized by the mammary cells or are transported by transcytosis from blood plasma. The intracellul
Publikováno v:
The Journal of biological chemistry. 274(42)
Overexpression of frequenin and its orthologue neuronal Ca(2+) sensor 1 (NCS-1) has been shown to increase evoked exocytosis in neurons and neuroendocrine cells. The site of action of NCS-1 and its biochemical targets that affect exocytosis are unkno
Autor:
R D, Burgoyne, A, Morgan
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 20(4)
Many of the proteins that function in regulated exocytosis have now been identified. Several proteins form part of a conserved core machinery that acts in many intracellular vesicular fusion steps and their essential roles confirmed by molecular gene
Publikováno v:
Biochemical Society symposium. 63
In an attempt to define control points within the secretory pathway for casein synthesis and secretion, we have examined the role of both cytosolic and intra-organelle Ca2+ in the control of casein synthesis, phosphorylation and secretion. In additio
Publikováno v:
FEBS letters. 393(2-3)
Soluble N-ethylmaleimide-sensitive fusion protein attachment proteins (SNAP) proteins function in Ca(2+)-regulated exocytosis. Recent work (Schiavo et al. (1996) Nature 378, 733-736) based on in vitro protein interactions has raised the possibility t
Autor:
R D, Burgoyne
Publikováno v:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 46(3)
Adrenaline and noradrenaline are released from adrenal medullary chromaffin cells by regulated exocytosis from stored secretory granules. Many aspects of the mechanisms by which exocytosis is activated in chromaffin cells are now understood in detail
Publikováno v:
Epithelial cell biology. 4(1)
Lactating mammary epithelial cells synthesize large quantities of milk proteins, which they secrete vectorially at the apical membrane into the alveolar lumen of the gland. Recent work suggested that mammary protein secretion is not wholly constituti
Publikováno v:
Journal of anatomy. 183
Recent advances have led to an increased understanding of the Ca(2+)-signalling pathway leading to exocytosis in bovine adrenal chromaffin cells. Video-imaging studies have allowed the temporal and spatial aspects of the Ca2+ signal to be investigate
Publikováno v:
Neuroscience letters. 142(1)
Following culture in high (25 mM) K+ conditions cerebellar granule cells only respond with a rise in cytosolic free calcium concentration ([Ca2+]i after removal of external Mg2+. When granule cells are grown in low (5 mM) K+ N-methyl-D-aspartate (NMD