Zobrazeno 1 - 10
of 34
pro vyhledávání: '"R D, Blakely"'
Autor:
E A, Ennis, R D, Blakely
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 76
Genetic, biochemical, physiological, and pharmacological approaches have advanced our understanding of cholinergic biology for over 100 years. High-affinity choline uptake (HACU) was one of the last features of cholinergic signaling to be defined at
Publikováno v:
Biochemical Society Transactions. 29:711-716
In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3)-sensitive choline transporter (CHT). This transporter exhibits micromo
Autor:
R, Ye, A M D, Carneiro, Q, Han, D, Airey, E, Sanders-Bush, B, Zhang, L, Lu, R, Williams, R D, Blakely
Publikováno v:
Genes, brain, and behavior. 13(3)
Presynaptic serotonin (5-hydroxytryptamine, 5-HT) transporters (SERT) regulate 5-HT signaling via antidepressant-sensitive clearance of released neurotransmitter. Polymorphisms in the human SERT gene (SLC6A4) have been linked to risk for multiple neu
Autor:
M S, Mazei-Robinson, R D, Blakely
Publikováno v:
Handbook of experimental pharmacology. (175)
The catecholamine dopamine (DA) plays an important role as a neurotransmitter in the brain in circuits linked to motor function, reward, and cognition. The presynaptic DA transporter (DAT) inactivates DA following release and provides a route for non
Autor:
M H, Bazalakova, R D, Blakely
Publikováno v:
Handbook of experimental pharmacology. (175)
In cholinergic neurons, the presynaptic choline transporter (CHT) mediates high-affinity choline uptake (HACU) as the rate-limiting step in acetylcholine (ACh) synthesis. It has previously been shown that HACU is increased by behaviorally and pharmac
Publikováno v:
Biochemical Society transactions. 29(Pt 6)
In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3)-sensitive choline transporter (CHT). This transporter exhibits micromo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Presynaptic, cocaine- and antidepressant-sensitive norepinephrine (NE) transporters (NETs) dictate levels of extracellular NE after vesicular release. Recent studies suggest that G protein-coupled receptors linked to protein kinase C (PKC) down-regul
Autor:
R D, Blakely
Publikováno v:
Science (New York, N.Y.). 293(5539)
Publikováno v:
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. 6(1)
Orthostatic intolerance (OI) is common after space flight and resembles the disabling idiopathic orthostatic intolerance commonly observed in otherwise healthy young individuals. OI can arise from reduced sympathetic nervous system activity and, para
Autor:
A R, Belous, S, Ramamoorthy, R D, Blakely, M I, Factor, A M, Dupin, A B, Katasonov, R H, Lozier, A G, Beniashvili, M A, Morozova, O S, Brusov
Publikováno v:
Neuroscience and behavioral physiology. 31(2)
The role of the serotonin transporter protein (STP) in the development of somatoform [corrected] disorders was addressed in a correlational study of the levels of immunoreactive STP (IR-STP) using site-specific antibodies against the least conserved