Zobrazeno 1 - 10
of 1 765
pro vyhledávání: '"R Clay"'
Autor:
R Clay Bunn, Reuben Adatorwovor, Rebecca R Smith, Philip D Ray, Sarah E Fields, Alexander R Keeble, Christopher S Fry, Sasidhar Uppuganti, Jeffry S Nyman, John L Fowlkes, Evangelia Kalaitzoglou
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bo
Externí odkaz:
https://doaj.org/article/92100dade6de4c38b7555d341607541a
Autor:
Sven Dorkenwald, Nicholas L Turner, Thomas Macrina, Kisuk Lee, Ran Lu, Jingpeng Wu, Agnes L Bodor, Adam A Bleckert, Derrick Brittain, Nico Kemnitz, William M Silversmith, Dodam Ih, Jonathan Zung, Aleksandar Zlateski, Ignacio Tartavull, Szi-Chieh Yu, Sergiy Popovych, William Wong, Manuel Castro, Chris S Jordan, Alyssa M Wilson, Emmanouil Froudarakis, JoAnn Buchanan, Marc M Takeno, Russel Torres, Gayathri Mahalingam, Forrest Collman, Casey M Schneider-Mizell, Daniel J Bumbarger, Yang Li, Lynne Becker, Shelby Suckow, Jacob Reimer, Andreas S Tolias, Nuno Macarico da Costa, R Clay Reid, H Sebastian Seung
Publikováno v:
eLife, Vol 11 (2022)
Learning from experience depends at least in part on changes in neuronal connections. We present the largest map of connectivity to date between cortical neurons of a defined type (layer 2/3 [L2/3] pyramidal cells in mouse primary visual cortex), whi
Externí odkaz:
https://doaj.org/article/27b1354692bd4be48848ffb48a230736
Autor:
Gayathri Mahalingam, Russel Torres, Daniel Kapner, Eric T Trautman, Tim Fliss, Shamishtaa Seshamani, Eric Perlman, Rob Young, Samuel Kinn, JoAnn Buchanan, Marc M Takeno, Wenjing Yin, Daniel J Bumbarger, Ryder P Gwinn, Julie Nyhus, Ed Lein, Steven J Smith, R Clay Reid, Khaled A Khairy, Stephan Saalfeld, Forrest Collman, Nuno Macarico da Costa
Publikováno v:
eLife, Vol 11 (2022)
Serial-section electron microscopy (ssEM) is the method of choice for studying macroscopic biological samples at extremely high resolution in three dimensions. In the nervous system, nanometer-scale images are necessary to reconstruct dense neural wi
Externí odkaz:
https://doaj.org/article/bd5f8cd87b2346a0937e74c351b6c225
Publikováno v:
eLife, Vol 11 (2022)
Division of labor between cells is ubiquitous in biology but the use of multicellular consortia for engineering applications is only beginning to be explored. A significant advantage of multicellular circuits is their potential to be modular with res
Externí odkaz:
https://doaj.org/article/bb05a6c1f78240ec9b2506922952af67
Autor:
Casey M Schneider-Mizell, Agnes L Bodor, Forrest Collman, Derrick Brittain, Adam Bleckert, Sven Dorkenwald, Nicholas L Turner, Thomas Macrina, Kisuk Lee, Ran Lu, Jingpeng Wu, Jun Zhuang, Anirban Nandi, Brian Hu, JoAnn Buchanan, Marc M Takeno, Russel Torres, Gayathri Mahalingam, Daniel J Bumbarger, Yang Li, Thomas Chartrand, Nico Kemnitz, William M Silversmith, Dodam Ih, Jonathan Zung, Aleksandar Zlateski, Ignacio Tartavull, Sergiy Popovych, William Wong, Manuel Castro, Chris S Jordan, Emmanouil Froudarakis, Lynne Becker, Shelby Suckow, Jacob Reimer, Andreas S Tolias, Costas A Anastassiou, H Sebastian Seung, R Clay Reid, Nuno Maçarico da Costa
Publikováno v:
eLife, Vol 10 (2021)
Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological, molecular, and connectivity signatures. While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lac
Externí odkaz:
https://doaj.org/article/7183b51f322941cfadb44572b84338f8
Autor:
Plant Cell Atlas Consortium, Suryatapa Ghosh Jha, Alexander T Borowsky, Benjamin J Cole, Noah Fahlgren, Andrew Farmer, Shao-shan Carol Huang, Purva Karia, Marc Libault, Nicholas J Provart, Selena L Rice, Maite Saura-Sanchez, Pinky Agarwal, Amir H Ahkami, Christopher R Anderton, Steven P Briggs, Jennifer AN Brophy, Peter Denolf, Luigi F Di Costanzo, Moises Exposito-Alonso, Stefania Giacomello, Fabio Gomez-Cano, Kerstin Kaufmann, Dae Kwan Ko, Sagar Kumar, Andrey V Malkovskiy, Naomi Nakayama, Toshihiro Obata, Marisa S Otegui, Gergo Palfalvi, Elsa H Quezada-Rodríguez, Rajveer Singh, R Glen Uhrig, Jamie Waese, Klaas Van Wijk, R Clay Wright, David W Ehrhardt, Kenneth D Birnbaum, Seung Y Rhee
Publikováno v:
eLife, Vol 10 (2021)
With growing populations and pressing environmental problems, future economies will be increasingly plant-based. Now is the time to reimagine plant science as a critical component of fundamental science, agriculture, environmental stewardship, energy
Externí odkaz:
https://doaj.org/article/ec5bec0044f24450ace1f74df430f9ce
Autor:
Lawrence Huang, Peter Ledochowitsch, Ulf Knoblich, Jérôme Lecoq, Gabe J Murphy, R Clay Reid, Saskia EJ de Vries, Christof Koch, Hongkui Zeng, Michael A Buice, Jack Waters, Lu Li
Publikováno v:
eLife, Vol 10 (2021)
Fluorescent calcium indicators are often used to investigate neural dynamics, but the relationship between fluorescence and action potentials (APs) remains unclear. Most APs can be detected when the soma almost fills the microscope’s field of view,
Externí odkaz:
https://doaj.org/article/82e769b44ca8434cb6517c2168640eea
Autor:
Anton Arkhipov, Nathan W Gouwens, Yazan N Billeh, Sergey Gratiy, Ramakrishnan Iyer, Ziqiang Wei, Zihao Xu, Reza Abbasi-Asl, Jim Berg, Michael Buice, Nicholas Cain, Nuno da Costa, Saskia de Vries, Daniel Denman, Severine Durand, David Feng, Tim Jarsky, Jérôme Lecoq, Brian Lee, Lu Li, Stefan Mihalas, Gabriel K Ocker, Shawn R Olsen, R Clay Reid, Gilberto Soler-Llavina, Staci A Sorensen, Quanxin Wang, Jack Waters, Massimo Scanziani, Christof Koch
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006535 (2018)
Despite advances in experimental techniques and accumulation of large datasets concerning the composition and properties of the cortex, quantitative modeling of cortical circuits under in-vivo-like conditions remains challenging. Here we report and p
Externí odkaz:
https://doaj.org/article/574a2817931b457b9ef5252488b72b54
Autor:
Timothy J Lee, Aditi Kumar, Aishwarya H Balwani, Derrick Brittain, Sam Kinn, Craig A Tovey, Eva L Dyer, Nuno M da Costa, R Clay Reid, Craig R Forest, Daniel J Bumbarger
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0206172 (2018)
Serial section transmission electron microscopy (ssTEM) is the most promising tool for investigating the three-dimensional anatomy of the brain with nanometer resolution. Yet as the field progresses to larger volumes of brain tissue, new methods for
Externí odkaz:
https://doaj.org/article/2de3ad31454a404085f5ae6ca5b6a208
Autor:
Daniel J Denman, Jennifer A Luviano, Douglas R Ollerenshaw, Sissy Cross, Derric Williams, Michael A Buice, Shawn R Olsen, R Clay Reid
Publikováno v:
eLife, Vol 7 (2018)
Mammalian visual behaviors, as well as responses in the neural systems underlying these behaviors, are driven by luminance and color contrast. With constantly improving tools for measuring activity in cell-type-specific populations in the mouse durin
Externí odkaz:
https://doaj.org/article/65496cc8a8e749f0989262cb2279e884