Zobrazeno 1 - 10
of 183
pro vyhledávání: '"R Challis"'
Autor:
S.E. Humphries, R. Challis, K. Downes, E. Howard, T. Legerton, C. Macanulty, S. Morgan, A. O’Rouke, D. O’Sullivan, A. Taylor-Beadling, E. Thompson, E. Watson, G. Norbury
Publikováno v:
Atherosclerosis Plus, Vol 54, Iss , Pp S9- (2023)
Externí odkaz:
https://doaj.org/article/12a1e74bf6e341a9a76116c59a36b2f1
Akademický článek
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Autor:
Ming-Qiang Zhang, Barrie Wilkinson, Christine Martin, Matthew Alan Gregory, Chrisostomos Prodromou, Laurence H. Pearl, Isabelle Carletti, Iain R. Challis, Sabine Gaisser, S. Mark Roe, Susan M. Boyd
Publikováno v:
Journal of Medicinal Chemistry. 51:2853-2857
Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being more soluble, stable, more potently inhibiting ATPase activity (IC50 = 2 microM) and binding with higher affinity (Kd = 0.24 microM). Structural studies reveal significant diffe
Autor:
Iain R. Challis, Lindsey Low, Peter F. Leadlay, Rolf Müller, Barrie Wilkinson, Steven G. Kendrew, Jose Garcia-Bernardo, Hans-Jürgen Hecht, Hrvoje Petković, Axel Sandmann, Barbara Silakowski, Enej Kuščer, Nicola Beeston
Publikováno v:
Org. Biomol. Chem.. 6:500-506
The production of epothilone mixtures is a direct consequence of the substrate tolerance of the module 3 acyltransferase (AT) domain of the epothilone polyketide synthase (PKS) which utilises both malonyl- and methylmalonyl-CoA extender units. Partic
Publikováno v:
Australasian Radiology. 48:207-210
Summary We present the case of post-biopsy subcapsular haematoma leading to infarction of the kidney. This is a very uncommon complication of percutaneous renal biopsy. The radiological findings in this case are shown, highlighting the sonographic fi
Autor:
Mark A. Freeman, Malcolm J. Mitchinson, Peter J. Kirkpatrick, Ian F. Dennis, Iain R. Challis, Peter L. Weissberg, Keri L.H. Carpenter
Publikováno v:
Free Radical Research. 37:1235-1244
Much experimental evidence suggests that lipid oxidation is important in atherogenesis and in epidemiological studies dietary antioxidants appear protective against cardiovascular events. However, most large clinical trials failed to demonstrate bene
Publikováno v:
Free Radical Research. 36:791-802
Epidemiologically, a high-carotenoid intake via a fruit- and vegetable-rich diet is associated with a decreased risk of various forms of cancer. The mechanisms by which carotenoids exert this protective effect are controversial. In this study, we exa
Autor:
Ian F. Dennis, Keri L.H. Carpenter, David S. Leake, Mark J. Arends, Malcolm J. Mitchinson, David Osborn, Colin H. Macphee, Iain R. Challis
Publikováno v:
Carpenter, K L, Dennis, I F, Challis, I R, Osborn, D P, Macphee, C H, Leake, D S, Arends, M J & Mitchinson, M J 2001, ' Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages ', FEBS Letters, vol. 505, no. 3, pp. 357-63 . https://doi.org/10.1016/S0014-5793(01)02840-X
The death of macrophages contributes to atheroma formation. Oxidation renders low-density lipoprotein (LDL) cytotoxic to human monocyte-macrophages. Lipoprotein-associated phospholipase A2 (Lp-PLA2), also termed platelet-activating factor acetylhydro
Autor:
A. Zsenei, Didier Ferrere, Marco Costa, John Hill, Marcel Vos, R. Challis, Szymon Gadomski, J. Kaplon, Carlos Lacasta, D. Macina, C. Haber, G. F. Moorhead, Manuel Lozano, Javier Sánchez, J. Bernabeu, C. Martinez, Philip Phillips, H. Niggli
Publikováno v:
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 466:397-405
During the August–September 1999 test beam in H8 at CERN three half-modules, equipped with different types of fast binary Front End electronics, have been tested. The results indicate that all three SCT electronics candidates satisfy ATLAS efficien
Autor:
Timothy M. Greenaway, David R. Challis, John Burgess, Venkateswaran Parameswaran, Joseph J. Shepherd, R David
Publikováno v:
Cancer. 83:428-434
BACKGROUND Enteropancreatic malignancy is an important cause of morbidity and mortality associated with multiple endocrine neoplasia type 1 (MEN 1). However, the risk factors and mechanisms of the tumorigenesis of this malignancy are poorly understoo