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In Vivo Assessment of Aortic Aneurysm Wall Integrity Using Elastin-Specific Molecular Magnetic Resonance Imaging

Autor: Alice Warley, Ulrike Blume, Michael S. Marber, Reza Razavi, Andrea J. Wiethoff, Sara Lacerda, Bernd Hamm, René M. Botnar, Ullrich Ebersberger, David C. Onthank, Tobias Schaeffter, Richard R. Cesati, Simon P. Robinson, Marcus R. Makowski, Christian Jansen

Publikováno v: Circulation: Cardiovascular Imaging. 7:679-689

Background— The incidence of abdominal aortic aneurysms (AAAs) has increased during the last decades. However, there is still controversy about the management of medium-sized AAAs. Therefore, novel biomarkers, besides aneurysmal diameter, are neede

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35dd63bef09f5acecfbc48fd9728da46
https://doi.org/10.1161/circimaging.113.001131

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Assessment of Elastin Deficit in a Marfan Mouse Aneurysm Model Using an Elastin-Specific Magnetic Resonance Imaging Contrast Agent

Autor: Simon P. Robinson, Alex R. Dalal, David C. Onthank, Matteo Milanesi, Fabian Emrich, Hideo Adachi, Michael P. Fischbein, Mamoru Arakawa, Henk Smit, Andrew J. Connolly, Homare Okamura, Michael V. McConnell, Benjamin A. Dake, Laura Pisani, Richard R. Cesati, Gyula Kotek

Publikováno v: Circulation Cardiovascular Imaging, 7(4), 690-696. Lippincott Williams & Wilkins

Background— Ascending aortic dissection and rupture remain a life-threatening complication in patients with Marfan syndrome. The extracellular matrix provides strength and elastic recoil to the aortic wall, thereby preventing radial expansion. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d702dece35afff22b5ec69bc708e4e8c
https://doi.org/10.1161/circimaging.114.001658

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Three-Dimensional Imaging of the Aortic Vessel Wall Using an Elastin-Specific Magnetic Resonance Contrast Agent

Autor: Simon P. Robinson, René M. Botnar, Alexandra Keithan, Christian von Bary, Marcus R. Makowski, David C. Onthank, Alice Warley, Sylvia Schachoff, Richard R. Cesati, Anne Preissel, Markus Schwaiger

Publikováno v: Investigative Radiology. 47:438-444

The aim of this study was to demonstrate the feasibility of high-resolution 3-dimensional aortic vessel wall imaging using a novel elastin-specific magnetic resonance contrast agent (ESMA) in a large animal model.The thoracic aortic vessel wall of 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df1d7b38e1229c1254cab4a01e6417b
https://doi.org/10.1097/rli.0b013e3182588263

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Preparation of Hexahydrobenzo[f]isoquinolines Using a Vinylogous Pictet−Spengler Cyclization

Autor: Richard R. Cesati, John A. Katzenellenbogen

Publikováno v: Organic Letters. 2:3635-3638

A vinylogous Pictet-Spengler cyclization has been carried out using activated aldehydes, ketones, and alkynes to prepare a variety of substituted hexahydrobenzo[f]isoquinolines. A unique set of conditions was utilized to effect efficient cyclization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7f97674a25608108d85531f3ae07e0
https://doi.org/10.1021/ol006533u

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Four-Coordinate Dimethylgallium Compounds Vary in Stability toward Hydrolysis

Autor: Cathy S. Cutler, Richard R. Cesati, Sara L. Pluth, J. A. Katzenellenbogen, Robert W. Chesnut

Publikováno v: Organometallics. 17:4889-4896

Four-coordinate dimethylgallium complexes were prepared by the reaction of dimethylgallium hydroxide with bidentate Lewis bases and evaluated for their stability toward decomplexation in water, a key property in determining their potential usefulness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e404e25a41968eb195debce75d69841
https://doi.org/10.1021/om980413x

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Evaluation of LMI1195, a novel 18F-labeled cardiac neuronal PET imaging agent, in cells and animal models

Autor: Padmaja Yalamanchili, Paula Silva, Joel Lazewatsky, Melanie Lamoy, David S. Casebier, Mikhail Kagan, Jody Bozek, Ajay Purohit, Mahesh Mistry, Michael Cdebaca, Mary Guaraldi, Radeke Heike S, Ming Yu, Richard R. Cesati, Matthias Broekema, Michael Azure, Simon P. Robinson, David C. Onthank

Publikováno v: Circulation. Cardiovascular imaging. 4(4)

Background— Heart failure has been associated with impaired cardiac sympathetic neuronal function. Cardiac imaging with radiolabeled agents that are substrates for the neuronal norepinephrine transporter (NET) has demonstrated the potential to iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd976cfd7cc3c0c17ca338ea4927814
https://pubmed.ncbi.nlm.nih.gov/21555377

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MRI of coronary wall remodeling in a swine model of coronary injury using an elastin-binding contrast agent

Autor: Arno Buecker, Elmar Spuentrup, Jörg Hausleiter, Alice Warley, Marcus R. Makowski, Markus Schwaiger, Richard R. Cesati, René M. Botnar, Alexandra Keithahn, Nikolaus Schickl, Anne Preissel, Sylvia Schachoff, Simonn Robinson, Christian von Bary, Albert Schömig, Joel Lazewatsky, David C. Onthank

Publikováno v: Circulation. Cardiovascular imaging. 4(2)

Background— The extracellular matrix (ECM) plays an important role in the pathogenesis of atherosclerosis and in-stent restenosis. Elastin is an essential component of the ECM. ECM degradation can lead to plaque destabilization, whereas enhanced sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0aecc969ea8ddc0bd0be1025c513dfd
https://pubmed.ncbi.nlm.nih.gov/21378029

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