Zobrazeno 1 - 10
of 15
pro vyhledávání: '"R C Eisensmith"'
Autor:
J D Roberts, C D Montgomery, I Nasonkin, A Hughes, B Fang, R C Eisensmith, J Li, X H Li, Y C Lin-Lee, Martha P. Mims
Publikováno v:
Journal of Clinical Investigation. 95:768-773
Elevations of plasma total or LDL cholesterol are major risk factors for cardiovascular disease. Efforts directed at preventing and treating cardiovascular disease have often focused on reducing the levels of these substances in the blood. The Watana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccec92c92e64a884fae6eeb7ccbfe615
https://doi.org/10.1172/jci117725
https://doi.org/10.1172/jci117725
Autor:
E. R. Naughton, R. C. Eisensmith, Li Jin, Alexei A. Goltsov, Savio L. C. Woo, Ranajit Chakraborty
Publikováno v:
Human Molecular Genetics. 2:577-581
Phenylketonuria (PKU) is an autosomal recessive genetic disorder caused by phenylalanine hydroxylase (PAH) deficiency. Individuals afflicted with PKU develop irreversible mental retardation that can be largely prevented by the administration of a low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0b75f41584db68d6a32c9f9083ae47
https://doi.org/10.1093/hmg/2.5.577
https://doi.org/10.1093/hmg/2.5.577
Publikováno v:
The journal of gene medicine. 3(1)
A major limitation of adenovirus-mediated gene therapy for metabolic and inherited diseases is the instability of transgene expression in vivo. This instability results, at least in part, from the inability of the vector genome to maintain the transg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3796fbcdedc7caddbf2bd77c6e3fb38b
https://pubmed.ncbi.nlm.nih.gov/11269336
https://pubmed.ncbi.nlm.nih.gov/11269336
Autor:
R C, Eisensmith, S L, Woo
Publikováno v:
Thrombosis and haemostasis. 78(1)
Over the past five years, significant advances have been made in the development of novel viral vector systems for the treatment of hemophilia B by somatic gene therapy. At present, both a sustained but partial or a complete but transient correction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29a6877f7af830567faed54d3be7fa35
https://pubmed.ncbi.nlm.nih.gov/9198122
https://pubmed.ncbi.nlm.nih.gov/9198122
Publikováno v:
Gene therapy. 3(9)
Transgene expression in studies of both gene function and gene therapy may be assisted considerably through the use of transcriptional regulatory elements which permit high-level, and/or tissue-specific gene expression. We have therefore evaluated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::caef9933239231d607dc627874f846f5
https://pubmed.ncbi.nlm.nih.gov/8875229
https://pubmed.ncbi.nlm.nih.gov/8875229
Autor:
R C, Eisensmith, D R, Martinez, A I, Kuzmin, A A, Goltsov, A, Brown, R, Singh, I I, Elsas LJ, S L, Woo
Publikováno v:
Pediatrics. 97(4)
To determine the molecular basis of phenylketonuria (PKU) and related hyperphenylalaninemia (HPA) and to establish correlations between phenylalanine hydroxylase (PAH) genotypes and biochemical and clinical phenotypes in an ethnically diverse US popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a17171a4bff37eb96b6cf82a6944662
https://pubmed.ncbi.nlm.nih.gov/8632937
https://pubmed.ncbi.nlm.nih.gov/8632937
Autor:
B, Fang, H, Wang, G, Gordon, D A, Bellinger, M S, Read, K M, Brinkhous, S L, Woo, R C, Eisensmith
Publikováno v:
Gene therapy. 3(3)
Two recombinant adenoviruses expressing either human alpha 1-antitrypsin (hAAT) or canine factor IX (cFIX) were modified so that they also contained a temperature-sensitive mutation (ts125) in the DNA binding protein encoded within the viral E2A regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7752b46ab215e14ee0a87b87b72707e
https://pubmed.ncbi.nlm.nih.gov/8646552
https://pubmed.ncbi.nlm.nih.gov/8646552
Autor:
M F, Wilkemeyer, K L, Smith, M M, Zarei, T A, Benke, J W, Swann, K J, Angelides, R C, Eisensmith
Publikováno v:
Journal of neuroscience research. 43(2)
Genetic manipulation offers great potential for studying the molecular and cellular processes which control or regulate the complex developmental properties of neurons. Gene transfer into neurons, however, is notoriously difficult. In this study we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8099431fe01f0e004b98d2eaa9039df3
https://pubmed.ncbi.nlm.nih.gov/8820964
https://pubmed.ncbi.nlm.nih.gov/8820964
Publikováno v:
Advances in experimental medicine and biology. 369
As the technology for gene therapy develops in vitro and in vivo in animal models, it is becoming clear that the three principal approaches--recombinant retroviruses, recombinant adenovirus, and direct DNA delivery--will ultimately have applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75fe59ffec33affec5880fbfb44a22e4
https://pubmed.ncbi.nlm.nih.gov/7598019
https://pubmed.ncbi.nlm.nih.gov/7598019
Autor:
R C, Eisensmith, S L, Woo
Publikováno v:
Advances in genetics. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16fff7911d8457bfc792344924282bc0
https://pubmed.ncbi.nlm.nih.gov/7741023
https://pubmed.ncbi.nlm.nih.gov/7741023