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Rapid determination of the anti-cancer drug Melphalan (AlkeranTM) in human serum and plasma by automated solid phase extraction and liquid chromatography tandem mass spectrometry

Autor: R. C. Causon, J. P. Allanson, I. D. Davies

Publikováno v: Chromatographia. 52:S92-S97

A bioanalytical method for the determination of the anticancer drug Melphalan (AlkeranTM) in human serum and plasma is described. Automated solid phase extraction of the analyte is carried out with C18 sorbent packed in a 96 well format microtitre pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81675fd20394d904be2a64d878d085aa
https://doi.org/10.1007/bf02493133

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Rapid determination of the anti-cancer drug chlorambucil (Leukeran) and its phenyl acetic acid mustard metabolite in human serum and plasma by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry

Autor: R. C. Causon, I. D. Davies, J. P. Allanson

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 732(1)

A bioanalytical method for the determination of the anticancer drug chlorambucil (Leukeran™) and its phenyl acetic acid mustard metabolite in human serum and plasma is described. Automated solid-phase extraction of the analytes is carried out with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8200cbf8725fc440eeda95bb7b081e95
https://pubmed.ncbi.nlm.nih.gov/10517234

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Peptide histidine valine: its haemodynamic actions and pharmacokinetics in man differ from those of vasoactive intestinal peptide and peptide histidine methionine

Autor: R. C. Causon, A. J. Camm, B. J. Chrysanthou, N. Benjamin, J. S. Gill, S.R. Bloom, DJ Webb, L. Meleagros, Yiangos Yiangou, J. R. Cockcroft

Publikováno v: Clinical science (London, England : 1979). 78(5)

1. The effects of intravenous and intra-arterial infusion of the peptides derived from prepro-vasoactive intestinal peptide, vasoactive intestinal peptide, peptide histidine methionine and peptide histidine valine, were examined in six healthy volunt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d1a26ec0a756c45c860c5b143f0f17
https://pubmed.ncbi.nlm.nih.gov/2162275

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EFFECTS OF TWO DIFFERING HALOTHANE CONCENTRATIONS ON THE METABOLIC AND ENDOCRINE RESPONSES TO SURGERY

Autor: Jacky M. Burrin, R. C. Causon, M. J. Brown, J.L. Paterson, George M. Hall, S. Lacoumenta

Publikováno v: British Journal of Anaesthesia. 58:844-850

The effects of two differing concentrations of halothane, 2.1 MAC or 1.2 MAC, on the metabolic and endocrine responses to abdominal hysterectomy were investigated. The changes in blood glucose and lactate values, and plasma glycerol, cortisol, insuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43646c81bd04517a9ca6dbed83b1e4a8
https://doi.org/10.1093/bja/58.8.844

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The effect of selective and non-selective beta-adrenoceptor blockade, and of naloxone infusion, on the hormonal mechanisms of recovery from insulin-induced hypoglycaemia in man

Autor: M. J. Brown, R. C. Causon, S. L. Lightman, J. G. Armitstead, N. J. A. Vaughan

Publikováno v: British Journal of Clinical Pharmacology. 16:718-721

The rise in plasma adenosine-3',5'-monophosphate occurring in response to insulin induced hypoglycaemia in normal human subjects, was abolished by non-selective beta-adrenoceptor blockade but unaffected by selective beta 1-adrenoceptor blockade. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143ce8b6cb61362b26ec89a91dabf58a
https://doi.org/10.1111/j.1365-2125.1983.tb02248.x

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Circadian Rhythms of Epinephrine and Norepinephrine in Man*

Autor: Christopher Linsell, Paul E. Mullen, R. C. Causon, M. J. Brown, Stafford L. Lightman

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 60:1210-1215

The diurnal rhythms of plasma epinephrine and norepinephrine were investigated in a group of normal young men. Sleep, posture, illumination, and food intake were monitored. Plasma epinephrine demonstrated a statistically significant diurnal rhythm, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a0eb55fabb14cbb051ac57d5b11440
https://doi.org/10.1210/jcem-60-6-1210

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Urinary catecholamines in essential hypertension: results of 24-hour urine catecholamine analyses from patients in the Medical Research Council trial for mild hypertension and from matched controls

Autor: M J, Brown, R C, Causon, V F, Barnes, P, Brennan, G, Barnes, G, Greenberg

Publikováno v: The Quarterly journal of medicine. 57(222)

Four consecutive 24-h urine samples were collected from 134 male and 134 female placebo-treated patients in the Medical Research Council Trial for Mild Hypertension. Similar samples were collected from age and sex-matched normotensive controls. On th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08d20572ee76c50e28d7217d5012b443
https://pubmed.ncbi.nlm.nih.gov/4080953

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