Zobrazeno 1 - 5
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pro vyhledávání: '"R C, Wilmouth"'
Autor:
Binhui, Wu, R C, Wilmouth
Publikováno v:
Molecules and cells. 25(1)
Cancer Osaka thyroid, also known as Tpl-2 (Cot) is a member of the MAP3K kinase family and plays a key role in the regulation of the immune response to pro-inflammatory stimuli such as lipopolysaccharide (LPS) and tumour necrosis factor-alpha (TNF-al
Autor:
R C, Wilmouth, K, Edman, R, Neutze, P A, Wright, I J, Clifton, T R, Schneider, C J, Schofield, J, Hajdu
Publikováno v:
Nature structural biology. 8(8)
Studies on the catalytic mechanism and inhibition of serine proteases are widely used as paradigms for teaching enzyme catalysis. Ground-breaking work on the structures of chymotrypsin and subtilisin led to the idea of a conserved catalytic triad for
Publikováno v:
European journal of biochemistry. 268(10)
Human beta-casomorphin-7 (NH2-Tyr-Pro-Phe-Val-Glu-Pro-Ile-CO2H) is a naturally occurring peptide inhibitor of elastase that has been shown to form an acyl-enzyme complex stable enough for X-ray crystallographic analysis at pH 5. To investigate the im
Publikováno v:
Nature structural biology. 7(11)
Time-resolved structural studies on biomolecular function are coming of age. Focus has shifted from studies on 'systems of opportunities' to a more problem-oriented approach, addressing significant questions in biology and chemistry. An important ste
Publikováno v:
The Biochemical journal.
beta-Lactams inhibit a range of enzymes via acylation of nucleophilic serine residues. Certain gamma-lactam analogues of monocyclic beta-lactams have also been shown to be reversible inhibitors of porcine pancreatic elastase (PPE), forming acyl-enzym