Zobrazeno 1 - 8
of 8
pro vyhledávání: '"R C, Sonders"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:2447-2453
The pharmacokinetics and safety of single ascending doses of clarithromycin (6-0-methylerythromycin A) were assessed in a placebo-controlled, double-blind, randomized trial with 39 healthy male volunteers. Subjects were randomized to receive single d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6981e11a983db692270929e60452a8e
https://doi.org/10.1128/aac.36.11.2447
https://doi.org/10.1128/aac.36.11.2447
Autor:
B A Bopp, R C Sonders, Douglas E. Rollins, D J Anderson, Kenneth N. Buchi, G R Granneman, J M Machinist, Keith G. Tolman
Publikováno v:
Xenobiotica. 16:11-20
14C-Estazolam (2 mg) administered orally to dogs and human subjects was rapidly and completely absorbed with peak plasma levels occurring within one hour. In humans, plasma levels peaked at 103 +/- 18 ng/ml and declined monoexponentially with a half-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab7606c2031e03f7080aa9b8a4efce0
https://doi.org/10.3109/00498258609043501
https://doi.org/10.3109/00498258609043501
Publikováno v:
Antimicrobial Agents and Chemotherapy. 23:803-807
In this study, we were concerned with the effect of probenecid on the pharmacokinetics of 1,000 mg of cefmenoxime administered over a 30-min period by intravenous infusion. Each of a total of 10 subjects received cefmenoxime twice, once with and once
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dabf60c3eb1d107f5ac6b55e008bc62
https://doi.org/10.1128/aac.23.6.803
https://doi.org/10.1128/aac.23.6.803
Publikováno v:
Clinical therapeutics. 10(5)
Terazosin, a new long-acting selective alpha 1-receptor antagonist, was studied in a crossover trial to assess the effect of age on oral and intravenous pharmacokinetics. Thirty healthy male and female volunteers between the ages of 23 and 75 years r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d7835c4232e470e30d42d679b10533d
https://pubmed.ncbi.nlm.nih.gov/2908805
https://pubmed.ncbi.nlm.nih.gov/2908805
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 20(9)
The present study was conducted to evaluate the single-dose pharmacokinetics of the pseudodisaccharide antibiotic, fortimicin A, in humans, following intravenous infusion of 2.5, 5.0, and 7.5 mg per kg doses of the free base (as fortimicin A sulfate)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4dcfa6d5206de42da4af045527904147
https://pubmed.ncbi.nlm.nih.gov/7141758
https://pubmed.ncbi.nlm.nih.gov/7141758
Publikováno v:
Antimicrobial agents and chemotherapy. 21(1)
This study was concerned with the single-dose, pharmacokinetics of cefmenoxime after intramuscular (i.m.) injections of 250, 500 and 1,000 mg; 1-h intravenous (i.v.) infusions of 500, 1,000, and 2,000 mg; and 5-min i.v. injections of 500, 1,000, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4050f3ac1ea8294cef82c058b9a41f
https://pubmed.ncbi.nlm.nih.gov/6282203
https://pubmed.ncbi.nlm.nih.gov/6282203
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 1(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2997672e6a2ec620f4455fc808a420a
https://pubmed.ncbi.nlm.nih.gov/4149708
https://pubmed.ncbi.nlm.nih.gov/4149708
Publikováno v:
Nature. 220:178-179
ALTHOUGH cyclamate is excreted largely unchanged in both laboratory animals and man1,2, recent reports have shown that cyclohexylamine can be a metabolite of cyclamate in some humans3,4. Kojima and Ichibagase3 reported the recovery in the urine of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c81617cbc584e1c603fa85f35fd56b
https://doi.org/10.1038/220178a0
https://doi.org/10.1038/220178a0