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Akademický článek

Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors

Autor: O. C. Rogers, D. M. Rosen, L. Antony, H. M. Harper, D. Das, X. Yang, I. Minn, R. C. Mease, M. G. Pomper, S. R. Denmeade

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Prostate cancer cells are characterized by a remarkably low proliferative rate and the production of high levels of prostate-specific proteases. Protein-based toxins are attractive candidates for prostate cancer therapy because they kill cel

Externí odkaz: https://doaj.org/article/9ccc999bbc6e4ef58648953c074fc96c

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Prostate-specific membrane antigen as a target for cancer imaging and therapy

Autor: A P, Kiess, S R, Banerjee, R C, Mease, S P, Rowe, A, Rao, C A, Foss, Y, Chen, X, Yang, S Y, Cho, S, Nimmagadda, M G, Pomper

Publikováno v: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 59(3)

The prostate-specific membrane antigen (PSMA) is a molecular target whose use has resulted in some of the most productive work toward imaging and treating prostate cancer over the past two decades. A wide variety of imaging agents extending from inta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c962cd8242db4c3e88ed671d8943162
https://pubmed.ncbi.nlm.nih.gov/26213140

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Comparison of the distribution of bromine-77-bromovinyl steroidal and triphenylethylene estrogens in the immature rat

Autor: E R, DeSombre, A, Hughes, R C, Mease, P V, Harper

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 31(9)

The specific uptake and distribution of steroidal and non-steroidal [77Br]bromovinylestrogens were studied in immature female rats to assess the potential of these radioligands for imaging or therapy of estrogen receptor (ER) positive cancers. E-17 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bce18ab999c208ebd22e7ef22cdd212f
https://pubmed.ncbi.nlm.nih.gov/2395021

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Development of a new radiolabel (203Pb) and new chelating agents for labeling monoclonal antibodies for imaging

Autor: S C, Srivastava, R C, Mease, G E, Meinken, L F, Mausner, Z, Steplewski

Publikováno v: Acta radiologica. Supplementum. 374

High liver uptake and slow body clearance presently limit the usefulness of 111In labeled antibodies for tumor imaging. We have investigated 203Pb as an alternative and better antibody label. The DTPA and cyclohexyl EDTA (CDTA) conjugates of an antic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0745e076300d9ee2518ec8b8292b97f
https://pubmed.ncbi.nlm.nih.gov/1966961

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Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons

Autor: E R, DeSombre, P V, Harper, A, Hughes, R C, Mease, S J, Gatley, O T, DeJesus, J L, Schwartz

Publikováno v: Cancer research. 48(20)

While theoretically feasible, estrogen receptor (ER)-directed radiotherapy of hormone-dependent cancers has not been realized because no ER-seeking ligand with an appropriate radiotoxic potential has been identified. Since an appropriate nuclide is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc37689c94df7d9c6507233a8e4fdbc2
https://pubmed.ncbi.nlm.nih.gov/3167838

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