Zobrazeno 1 - 10
of 11
pro vyhledávání: '"R C, Grafstrom"'
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Epithelial inflammation may play an obligatory role in the pathogenesis of a number of chronic pulmonary diseases such as asthma or bronchitis and has been implicated during the promotion phase of multistage carcinogenesis. At sites of inflammation,
Publikováno v:
Progress in clinical and biological research. 347
Fecapentaenes are mutagenic to both bacterial and human cells and can morphologically transform murine Balb/c 3T3 cells. DNA damage induced by fecapentaene-12 includes DNA cross-links, DNA protein cross-links and single strand breaks. Oxy- and alkyl-
Publikováno v:
Cancer research. 45(12 Pt 1)
Human colon and bronchus tissue explants were incubated with either [3H]benzo(a)pyrene ([3H]BP) or [3H]-6-nitrobenzo(a)pyrene ([3H]-6-NBP). The total percentage of metabolism of BP and 6-NBP was, respectively, 8-59% and 18-41% in bronchus and 11-23%
Publikováno v:
Basic life sciences. 24
Publikováno v:
Cancer research. 48(4)
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits growth and induces terminal squamous differentiation of normal human bronchial cells when added to the culture media [J. C. Willey, A. J. Saladino, C. Ozanne, J. F. Lechner, and C
Publikováno v:
Cancer research. 47(8)
We investigated the effect of cigarette smoke condensate (CSC), two basic fractions (BIa and BIb) of CSC, the ethanol-extracted weakly acidic fraction (WAe), and the methanol-extracted neutral fraction (Nmeoh) on the clonal growth rate, plasminogen a
Publikováno v:
Cancer research. 42(3)
The metabolism of benzo(a)pyrene has been investigated in cultured normal human bronchus, colon, duodenum, and esophagus obtained from the same patient. The highest total metabolism was found in bronchus and duodenum, while the highest mean binding l
Publikováno v:
Cancer research. 43(3)
The oxidative metabolism of benzo(a)pyrene and the conjugative metabolism of 1-naphthol by explant cultures of normal human colon and colonic tumor tissue, obtained at surgery, have been studied. After 24 hr in culture, the explants were exposed to e
Publikováno v:
Cancer research. 45(6)
The effects of several aldehydes and peroxides on growth and differentiation of normal human bronchial epithelial cells were studied. Cells were exposed to formaldehyde, acetaldehyde, benzoyl peroxide (BPO), or hydrogen peroxide (HPO). The effect of
Publikováno v:
Cancer research. 44(7)
Normal adult human tissues and cultured bronchial epithelial cells and fibroblasts exhibit O6-alkylguanine-DNA alkyltransferase activity in vitro by catalyzing the repair of the promutagenic alkylation lesion O6-methylguanine from DNA. The amount rep