Zobrazeno 1 - 10
of 364
pro vyhledávání: '"R C, Coombes"'
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Breast cancer is the second most common cause of cancer mortality worldwide. Biomarker discovery has led to advances in understanding molecular phenotyping and thus has a great potential for precision management of this diverse di
Externí odkaz:
https://doaj.org/article/f533f7e20e2b4649ab691cd5125322d8
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with advanced malignancies was designed (ClinicalTrials.gov: NCT03363893). Here we rep
Externí odkaz:
https://doaj.org/article/b14be29b81754bafad04d4aa37714251
Autor:
R. C. Coombes, P. D. Badman, J. P. Lozano-Kuehne, X. Liu, I. R. Macpherson, I. Zubairi, R. D. Baird, N. Rosenfeld, J. Garcia-Corbacho, N. Cresti, R. Plummer, A. Armstrong, R. Allerton, D. Landers, H. Nicholas, L. McLellan, A. Lim, F. Mouliere, O. E. Pardo, M. J. Seckl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
FGFR-1 upregulation has been associated with endocrine therapy resistance in breast cancer patients. Here the authors report the results of a phase IIa study to assess the safety and efficacy of AZD454, an inhibitor of FGFR-1, 2 and 3 receptor tyrosi
Externí odkaz:
https://doaj.org/article/dd21946084ab4cad9d70fb08c6b96016
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4ff05e79a58f49b980db63215fe0a4b3
Autor:
R. C. Coombes, P. D. Badman, J. P. Lozano-Kuehne, X. Liu, I. R. Macpherson, I. Zubairi, R. D. Baird, N. Rosenfeld, J. Garcia-Corbacho, N. Cresti, R. Plummer, A. Armstrong, R. Allerton, D. Landers, H. Nicholas, L. McLellan, A. Lim, F. Mouliere, O. E. Pardo, V. Ferguson, M. J. Seckl
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a49b3f62276b4ad18eb4fc87fff91c8d
Autor:
Karen Page, Daniel Fernandez-Garcia, Amelia J Rushton, Luke Martinson, Justin Stebbing, Jacqui Shaw, Robert K. Hastings, David S. Guttery, R. C. Coombes, Molly C Gray, Kelly L. T. Gleason, K. Goddard
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 32(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaee55efec3f455c507dbcb60a5ed40
https://pubmed.ncbi.nlm.nih.gov/33932505
https://pubmed.ncbi.nlm.nih.gov/33932505
Autor:
Sahirzeeshan Ali, E. Ainscow, Ash Bahl, Sagar Sardesai, Janine Mansi, H-T. Arkenau, M. Lehnert, P. Richards, Simon Lord, S. McIntosh, Glen Clack, R. C. Coombes, Sacha J Howell, Laura M. Kenny, Z. Mitri, Rinath Jeselsohn, Joyce O'Shaughnessy, Matthew G Krebs, Carlo Palmieri, William J. Gradishar
Publikováno v:
Annals of Oncology. 32:S477-S478
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08b6b9a5d594a26b1180a26321d43ebd
https://doi.org/10.1016/j.annonc.2021.08.548
https://doi.org/10.1016/j.annonc.2021.08.548
Autor:
R. C. Coombes, A.B. Moreno-Cardenas, L Primrose, Jacqui Shaw, Karen Page, R.K. Hastings, M.R. Openshaw, David S. Guttery, M. Vazquez, Anne L. Thomas, Daniel Fernandez-Garcia, Cathy J. Richards, Josep Tabernero, R.A. Toledo, B. Toghill, L. Martinson, K. Kulbicki, Sharif Uddin Ahmed
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 32(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc65b4445f70c51495df5f28141dab1
https://pubmed.ncbi.nlm.nih.gov/33609721
https://pubmed.ncbi.nlm.nih.gov/33609721
Autor:
Karen Page, Daniel Fernandez-Garcia, David S. Guttery, Cathy J. Richards, A.B. Moreno-Cardenas, L Primrose, Mark R Openshaw, Sharif Uddin Ahmed, Bradley J. Toghill, Luke Martinson, Josep Tabernero, R.A. Toledo, M. Vazquez, Robert K. Hastings, R. C. Coombes, Anne Thomas, Jacqui Shaw, K Kulbicki
Little is known about the metastatic evolutionary dynamics of BRCA2-mutated cancers. Here, we applied whole-exome sequencing (WES) of primary tumor (PT), local relapse (LR) and eight serial plasma cfDNA samples collected from disease progression to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a7d66f5698c86f232bbe82d1531a2d
Autor:
Marianna Inglese, Eric O. Aboagye, Kasia Kozlowski, Francesco Mauri, Andrew Thornton, R C Coombes, Laura M. Kenny, Shairoz Merchant, N Masrour, N Rama, Susan Cleator, Adrian Lim, Kathrin Heinzmann, Conrad R. Lewanski, J F Steel, Ioannis Lavdas, Suraiya Dubash
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 45:2285-2299
Background Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ca69df382df689c6c7d36029ab9d2f
https://doi.org/10.1007/s00259-018-4098-9
https://doi.org/10.1007/s00259-018-4098-9