Zobrazeno 1 - 10
of 34
pro vyhledávání: '"R C, Budd"'
Publikováno v:
The Journal of Immunology. 154:6372-6381
The inert quality of MRL-Ipr/Ipr (Ipr) peripheral CD4-CD8- (CD4-8-) T cells manifests primarily as an inability to proliferate or produce IL-2 in response to TCR or mitogenic stimulation. Yet these same cells do initiate early TCR-mediated signaling
Publikováno v:
The Journal of Immunology. 154:2063-2074
The CD4-CD8- T cells that accumulate in lpr/lpr mice have previously expressed CD8, on the basis of studies of CD8 alpha gene demethylation. The actual requirement for CD8 interaction with class I MHC molecules to promote the appearance of CD4-CD8- T
Publikováno v:
The Journal of Immunology. 151:1086-1096
MRL lpr/lpr (lymphoproliferative, lpr) mice demonstrate an age-dependent lymphoproliferation and development of autoimmunity. Characteristic of the lymphoproliferation in these mice is the accumulation of large numbers of CD4-CD8-(CD4-8-),CD3+ T lymp
Autor:
N Van Houten, R C Budd
Publikováno v:
The Journal of Immunology. 149:2513-2517
MRL-lpr/lpr (lpr) mice develop a polyclonal accumulation of abnormal peripheral T lymphocytes, which bear surface alpha beta TCR, CD3, and the B220 isoform of CD45, but lack CD4, CD8, and CD2. These T cells have a constitutively phosphorylated CD3 ze
Publikováno v:
The Journal of Immunology. 148:1055-1064
The T lymphocytes that accumulate in vast numbers in the lymphoid tissues of lpr/lpr (lpr) mice express a TCR-alpha beta that is polyclonally rearranged, and yet is devoid of surface CD4 or CD8 (CD4-8-) as well as CD2. lpr CD2- alpha beta + CD4-8- T
Publikováno v:
The Journal of Immunology. 145:2862-2872
The predominant T lymphocytes that accumulate in the peripheral lymphoid tissues of mice homozygous for the lpr gene bear the phenotype CD3+CD4-CD8-. By certain functional criteria these cells would appear to have impaired CD3-mediated signal transdu
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(10)
The origin of TCR-alphabeta+ CD4-CD8- cells is unclear, yet accumulating evidence suggests that they do not represent merely a default pathway of unselected thymocytes. Rather, they arise by active selection as evidenced by their absence in mice lack
Autor:
M S, Vincent, K, Roessner, T, Sellati, C D, Huston, L H, Sigal, S M, Behar, J D, Radolf, R C, Budd
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(10)
Lyme arthritis synovial fluid contains a large proportion of gamma delta T cells that proliferates upon stimulation with the causative spirochete, Borrelia burgdorferi. A panel of Borrelia-reactive gamma delta T cell clones was derived from synovial
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(2)
The CD40/CD40L (CD40 ligand) axis regulates several interactions between T cells and B cells. Blocking of CD40 engagement by CD40L inhibits Ig class switch by B cells as well as diminishes T cell response to an immunizing Ag. For these reasons, disru
Autor:
N J, Kennedy, R C, Budd
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(10)
Fas (Apo-1, CD95), a member of the TNFR family, is expressed on a variety of cell types and transduces an apoptotic signal. Since Fas does not possess known enzymatic activities, proteins that interact with the cytoplasmic domain of Fas regulate the