Výsledky vyhledávání - "R C, Bethell"

In Vitro Interactions between Apricitabine and Other Deoxycytidine Analogues

Autor: A. Richard, P. Collins, J. Lippens, B. Hamelin, R. C. Bethell, J. M. de Muys, C. Ren

Publikováno v: Antimicrobial Agents and Chemotherapy. 51:2948-2953

Apricitabine is a novel deoxycytidine analogue reverse transcriptase inhibitor that is under development for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. Apricitabine is phosphorylated to its active triphosphate by deoxycyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a37e7fbfce3521cdf8300240ae99c5
https://doi.org/10.1128/aac.01204-06

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In Vitro Antiretroviral Activity and In Vitro Toxicity Profile of SPD754, a New Deoxycytidine Nucleoside Reverse Transcriptase Inhibitor for Treatment of Human Immunodeficiency Virus Infection

Autor: J. Lippens, C. Ren, P. McKenna, R. F. Rando, B. Allard, N. Nguyen-Ba, R. C. Bethell, J. M. de Muys, Zhengxian Gu, Debra L. Taylor

Publikováno v: Antimicrobial Agents and Chemotherapy. 50:625-631

SPD754 (AVX754) is a deoxycytidine analogue nucleotide reverse transcriptase inhibitor (NRTI) in clinical development. These studies characterized the in vitro activity of SPD754 against NRTI-resistant human immunodeficiency virus type 1 (HIV-1) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65827a82b9b21aa1b57f4a8921453375
https://doi.org/10.1128/aac.50.2.625-631.2006

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Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

Autor: Helen Taylor, R. C. Bethell, Alan J. Wonacott, Anne Cleasby, Andrew R. Whittington, Peter M. Colman, Tadeusz Skarzynski, Jose Varghese, Jan Scicinski, Steven L. Sollis, O.M. Singh, Peter C. Cherry, Paul W. Smith, Neil Taylor, Kevin N. Cobley, Peter D. Howes

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2931-2936

The structure-activity relationships of a series of 4-amino and guanidino-4H-pyran-2-carboxylic acid 6-carboxamides are described. These compounds represent a new class of inhibitor of influenza sialidases and are particularly active against influenz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f63b36b36a33bcb4ad4346f74168bdd3
https://doi.org/10.1016/s0960-894x(96)00542-2

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Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase

Autor: Peter C. Cherry, Steven L. Sollis, Paul W. Smith, Peter D. Howes, R. C. Bethell

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:1805-1808

N-Propylcarboxamides 1a,b–3a,b have been synthesised from 2,3-didehydro-2,4-dideoxy-4-amino-N-acetylneuraminic acid 4. The tertiary amides 2a,b–3a,b are highly potent but selective inhibitors of influenza A sialidase. The exceptional inhibitory a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::074c2b9de71700018730bb425bfc25db
https://doi.org/10.1016/0960-894x(96)00318-6

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Review: Anti-infectives Recent developments in the antiviral therapy of influenza

Autor: R. C. Bethell, Andrew R. Whittington

Publikováno v: Expert Opinion on Therapeutic Patents. 5:793-803

The patent literature on anti-influenza therapies covering the period 1993 to the first half of 1995 is reviewed. The antiviral intervention strategies used to combat influenza A and B are summarised, detailing the current status in each area and new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6c31c187f1bca3d9e9a8b5a8b087e12
https://doi.org/10.1517/13543776.5.8.793

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Benzophenone Derivatives: A Novel Series of Potent and Selective Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Autor: R. C. Bethell, Charon D, Dodic N, Nicholas Cammack, Darren V. S. Green, P. G. Wyatt, Dumaitre B, D. C. Humber, Derek N. Evans, Hopewell Pl

Publikováno v: Journal of Medicinal Chemistry. 38:1657-1665

A series of benzophenone derivatives has been synthesized and evaluated as inhibitors of HIV-1 reverse transcriptase (RT) and the growth of HIV-1 in MT-4 cells. Through the use of the structure-activity relationships within this series of compounds a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0512c95a0d2367b0ede53c1883d9c331
https://doi.org/10.1021/jm00010a010

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Synthesis and biological activity of the diphosphorylphosphonate derivatives of (+)- and (–)-cis-9-(4′-hydroxycyclopent-2′-enyl)guanine

Autor: R. C. Bethell, Valeria Merlo, Stanley M. Roberts, Richard Storer

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1477-1481

The carbovir triphosphate analogue 10 and its enantiomer 11 have been synthesized and tested as inhibitors of HIV-reverse transcriptase; the enantiomer 11, more remotely resembling natural nucleotides in stereochemical terms, is surprisingly the more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::572c9dcc217c3c02fdeed25008ea0e2e
https://doi.org/10.1039/p19940001477

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Biochemical Methods for the Characterization of Influenza Viruses with Reduced Sensitivity to 4-Guanidino-Neu5Ac2en

Autor: R C, Bethell, G J, Hart, T J, Blick, A, Sahasrabudhe, J L, McKimm-Breschkin

Publikováno v: Methods in molecular medicine. 24

Viruses that are less sensitive to the influenza neuraminidase (NA)-specific inhibitor 4-guanidino-Neu5Ac2en (zanamavir) (1) can be isolated after several passages in MDCK cells in the presence of the inhibitor. Although there are three reports of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8f6495ae648ce8df7c4a53a18d88979
https://pubmed.ncbi.nlm.nih.gov/21331923

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Virological Methods for the Generation and Characterization of Influenza Viruses with Reduced Sensitivity to 4-Guanidino-Neu5Ac2en

Autor: J L, McKimm-Breschkin, A, Sahasrabudhe, T J, Blick, A J, Jowett, R C, Bethell

Publikováno v: Methods in molecular medicine. 24

The compound 4-guanidino-Neu5Ac2en (zanamivir) has been described as a selective inhibitor of the influenza virus neuraminidase (NA) (1). Viruses that are less sensitive to this inhibitor can be isolated after several passages in MDCK cells in the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b977ae115abc7811d444c1bd15f606b
https://pubmed.ncbi.nlm.nih.gov/21331924

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