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Autor:
Honorio eSilva, Peter eStonier, Fritz R Buhler, Jean-Paul eDeslypere, Domenico eCriscuolo, Gerfried eNell, Joao eMassud, Stewart eGeary, Johanna eSchenk, Sandor eKerpel-Fronius, Greg eKoski, Norbert eClemens, Ingrid eKlingmann, Gustavo eKesselring, Rudolf evan Olden, Dominique J Dubois
Publikováno v:
Frontiers in Pharmacology, Vol 4 (2013)
Professional groups, such as IFAPP (International Federation of Pharmaceutical Physicians and Pharmaceutical Medicine), are expected to produce the defined core competencies to orient the discipline and the academic programs for the development of fu
Externí odkaz:
https://doaj.org/article/f780c6dd5ead40a9ad389d815321e0c4
Publikováno v:
ILAR Journal. 53:114-125
During the past decade, the zebrafish has emerged as a leading model for mechanistic cancer research because of its sophisticated genetic and genomic resources, its tractability for tissue targeting of transgene expression, its efficiency for forward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bac88e1f83a40b095b2c96464b8e16b
https://doi.org/10.1093/ilar.53.2.114
https://doi.org/10.1093/ilar.53.2.114
Autor:
Patricia L. Stapleton, Theo K. Bammler, Julia H. Tracy, Kerstin Gross-Steinmeyer, Stephen C. Strom, Donald R. Buhler, David L. Eaton
Publikováno v:
Toxicological Sciences. 112:303-310
This study employed cultured human primary hepatocytes to investigate the ability of the putative chemopreventive phytochemicals curcumin (CUR), 3,3'-diindolylmethane (DIM), isoxanthohumol (IXN), or 8-prenylnaringenin (8PN) to reduce DNA adduct forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bb2e83702978052451761a6cca4304
https://doi.org/10.1093/toxsci/kfp206
https://doi.org/10.1093/toxsci/kfp206
Autor:
William M. Baird, Jun-Lan Wang-Buhler, T. Musafia-Jeknic, Woon-Gye Chung, Donald R. Buhler, Cristobal L. Miranda
Publikováno v:
Aquatic Toxicology. 80:101-108
The zebrafish (Danio rerio) is a sensitive non-mammalian model used for studying polycyclic aromatic hydrocarbon (PAH)-induced chemical carcinogenesis. The susceptibility of zebrafish to PAH-induced carcinogenesis may be related to the ability of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f10fde8faf795d2c720a901c7842bf
https://doi.org/10.1016/j.aquatox.2006.07.018
https://doi.org/10.1016/j.aquatox.2006.07.018
Autor:
Woon-Gye Chung, Chin-Hwa Hu, Hua-Pin Tseng, Donald R. Buhler, Jun-Lan Wang-Buhler, Hsiao-Ting Su, Graham E. Corley-Smith, Thuy Hoang
Publikováno v:
Biochemical and Biophysical Research Communications. 340:1039-1046
We report a new cytochrome P450 (CYP) subfamily CYP3C and the cloning through PCR from zebrafish ( Danio rerio ) of the first member, CYP3C1 ( AY499002 ). The CYP3C1 gene is on Chromosome 3 with 13 ORF exons encoding a 505 amino acid protein which ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eb883703d312ee193158c4d929d376
https://doi.org/10.1016/j.bbrc.2005.12.110
https://doi.org/10.1016/j.bbrc.2005.12.110
Publikováno v:
Toxicology and Applied Pharmacology. 205:247-258
In mammals, CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal CYP protein. They are involved in the metabolism of an extensive range of endogenous substrates and xenobiotics and make a significant contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a66be49ea3f2d746a21ae7afba0a88f
https://doi.org/10.1016/j.taap.2004.10.019
https://doi.org/10.1016/j.taap.2004.10.019
Autor:
Alan W. Taylor, Cristobal L. Miranda, Donald R. Buhler, V. Bomben, X. Liang, Max L. Deinzer, Jan F. Stevens, J.S. Beckman
Publikováno v:
Acta Horticulturae. :207-212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e9b7f4b8d90ed6dd0b8bad61957d13f
https://doi.org/10.17660/actahortic.2005.668.26
https://doi.org/10.17660/actahortic.2005.668.26
Autor:
Woon-Gye Chung, Tzong-Hsiung Hseu, Chin-Hwa Hu, Jun-Lan Wang-Buhler, Hua-Pin Tseng, Cristobal L. Miranda, Donald R. Buhler, Yea-Huey Yang, Jan F. Stevens, M. Westerfield, Su-Jun Lee
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 140:207-219
A full-length zebrafish (Danio rerio) cytochrome P450 (CYP) 2K6 cDNA, was obtained (GenBank accession No. AF283813) through polymerase chain reaction cloning using degenerated primers based on a consensus CYP2 sequence and the heme-binding domain. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a506249ffd0ff83050eaa99147c3c83
https://doi.org/10.1016/j.cca.2005.02.002
https://doi.org/10.1016/j.cca.2005.02.002
Publikováno v:
American Journal of Veterinary Research. 65:1563-1572
Objective—To compare hepatic metabolism of pyrrolizidine alkaloids (PAs) between sheep and cattle and elucidate the protective mechanism of sheep. Sample Population—Liver microsomes and cytosol from 8 sheep and 8 cattle. Procedure—The PA seneci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447e82732decae5b956190387353b3b0
https://doi.org/10.2460/ajvr.2004.65.1563
https://doi.org/10.2460/ajvr.2004.65.1563