Zobrazeno 1 - 10
of 111
pro vyhledávání: '"R Bryan Sutton"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110152- (2024)
Summary: The mouse epididymis is a long tubule connecting the testis to the vas deferens. Its primary functions are to mature spermatozoa into motile and fertile cells and to protect them from pathogens that ascend the male tract. We previously demon
Externí odkaz:
https://doaj.org/article/ba88ca6aa0d94f4a98537c517fb04e0a
Autor:
Jon J. McCord, Minal Engavale, Elahe Masoumzadeh, Johanna Villarreal, Britney Mapp, Michael P. Latham, Peter A. Keyel, R. Bryan Sutton
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Biophysical, structural, and functional characterization of Dnase1L3 reveals differences in DNA binding and degradation mechanisms between Dnase1 and Dnase1L3 facilitated by Dnase1L3’s intrinsically disordered C-terminal domain.
Externí odkaz:
https://doaj.org/article/b5dde99e64814032bb179e63a3fbf02f
Autor:
Minal Engavale, Jon McCord, Britney Mapp, Nadine Nzimulinda, Elisabeth Bengtson, R. Bryan Sutton, Peter A. Keyel
Publikováno v:
Encyclopedia, Vol 1, Iss 3, Pp 527-541 (2021)
The deoxyribonuclease 1 (Dnase1) family is a key family of endonucleases that degrades DNA. Loss of Dnase1 family function causes several diseases where the host’s immune system targets the host, such as systemic lupus erythematosus, hypocomplement
Externí odkaz:
https://doaj.org/article/1830cadd1b844e6bae933899a7b7f245
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270188 (2022)
Ferlins are complex, multi-domain proteins, involved in membrane trafficking, membrane repair, and exocytosis. The large size of ferlin proteins and the lack of consensus regarding domain boundaries have slowed progress in understanding molecular-lev
Externí odkaz:
https://doaj.org/article/963002a30b464c2c9ce1863e9f93ae45
Autor:
R. Bryan Sutton
Publikováno v:
Southwest Respiratory and Critical Care Chronicles, Vol 6, Iss 23, Pp 1-3 (2018)
Externí odkaz:
https://doaj.org/article/aeb383cf9f6c4fc7b47c7de710e159f2
Autor:
Isaac L. Scott, Matthew J. Dominguez, Adam Snow, Faraz M. Harsini, Justin Williams, Kerry L. Fuson, Roshan Thapa, Pushpak Bhattacharjee, Gail A. Cornwall, Peter A. Keyel, R. Bryan Sutton
Publikováno v:
bioRxiv
Limb-Girdle Muscular Dystrophy Type-2B/2R is caused by mutations in thedysferlingene (DYSF). This disease has two known pathogenic missense mutations that occur within dysferlin’s C2A domain, namely C2AW52Rand C2AV67D. Yet, the etiological rational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86334900b6dfa65d722438b3336c834
https://doi.org/10.1101/2023.04.24.538129
https://doi.org/10.1101/2023.04.24.538129
Autor:
Minal Engavale, Colton J. Hernandez, Angelica Infante, Tanya LeRoith, Elliott Radovan, Lauryn Evans, Johanna Villarreal, Christopher M. Reilly, R. Bryan Sutton, Peter A. Keyel
Publikováno v:
bioRxiv
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease caused by environmental factors and loss of key proteins. One such protein is a serum endonuclease secreted by macrophages and dendritic cells, Dnase1L3. Loss of Dnase1L3 causes pedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937d5f8772081ec4326a9660e59b4b30
https://doi.org/10.1101/2023.04.17.537232
https://doi.org/10.1101/2023.04.17.537232
Autor:
Nazmul H Khan, Anthony A Bui, Yang Xiao, R Bryan Sutton, Robert W Shaw, Benjamin J Wylie, Michael P Latham
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214440 (2019)
The hydrolysis of β-lactam antibiotics by β-lactamase enzymes is the most prominent antibiotic resistance mechanism for many pathogenic bacteria. Out of this broad class of enzymes, metallo-β-lactamases are of special clinical interest because of
Externí odkaz:
https://doaj.org/article/b06f4fd85931481b978be919b54b1ff1
Autor:
Chi Wang, Zhengrong Yang, Blaine J. Loughlin, Haijin Xu, Guido Veit, Sergey Vorobiev, Oliver B. Clarke, Fan Jiang, Yaohui Li, Shikha Singh, Zachary Rich, Elizabeth R. Menten, Robert A. Grassucci, Wei Wang, Allison Mezzell, Ziao Fu, Kam-Ho Wong, Jing Wang, Diana R. Wetmore, R. Bryan Sutton, Christie G. Brouillette, Ina L. Urbatsch, John C. Kappes, Gergely L. Lukacs, Joachim Frank, John F. Hunt
Cystic fibrosis (CF) is caused by mutations in a chloride channel called the human Cystic Fibrosis Transmembrane Conductance Regulator (hCFTR). We used cryo-EM global conformational ensemble reconstruction to characterize the mechanism by which the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8099769d8252d91e0952af46cc5ab09
https://doi.org/10.1101/2022.10.10.510913
https://doi.org/10.1101/2022.10.10.510913
Autor:
Jon J. McCord, Minal Engavale, Elahe Masoumzadeh, Johanna Villarreal, Britney Mapp, Michael P. Latham, Peter A. Keyel, R. Bryan Sutton
Publikováno v:
Communications biology. 5(1)
Autoimmunity develops when extracellular DNA released from dying cells is not cleared from serum. While serum DNA is primarily digested by Dnase1 and Dnase1L3, Dnase1 does not rescue autoimmunity arising from Dnase1L3 deficiencies. Dnase1L3 uniquely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa8839e22eeb4091f353ea7d3b9efc0
https://pubmed.ncbi.nlm.nih.gov/35974043
https://pubmed.ncbi.nlm.nih.gov/35974043